“…Since our earlier studies and publications investigating BIOCERAMIC [20][21][22][23][24][25][26][27], mostly focused on basic medical science of cells and animal models, and we had showed that BIOCERAMIC promotes the microcirculation and has other effects by upregulating calcium-dependent nitric oxide and calmodulin in different cell lines, an antioxidant effect by increasing the hydrogen peroxide-scavenging ability of different cells, including murine macrophages (RAW264.7), murine calvaria-derived osteoblast-like cells (MC3T3-E1), NIH3T3 fibroblast cells, and murine myoblast cells (C2C12). In addition, another published data show that BIOCERAMIC irradiation had significant inhibition of PGE-2, COX-2 and iNOS, (inflammatory and pain inducing factors) elevations during lipopolysaccharide-induction in both murine macrophages and human chondrosarcoma cell line.…”