Effects of fasting and re-feeding on the expression of CCK, PYY, hypothalamic neuropeptides, and IGF-related genes in layer and broiler chicks

Kewan, Ahmed; Saneyasu, Takaoki; Kamisoyama, Hiroshi; Honda, Kazuhisa

doi:10.1016/j.cbpa.2021.110940

Cited by 6 publications

(3 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the case of CCK expression we also have limited evidence for changes, although it is clear that CCK is released in response to increased food intake [17] and both CCK in the small intestine and PYY in the pancreas and jejunum were observed to change after fasting. These results were influenced by the strain of chicken, being absent in some tissues of the broiler suggesting the feedback may be altered in these genotypes [23]. There are examples of studies that see changes in expression of CCK and its receptor [1] but they use changes in GAPDH as a control gene that alters with feed availability [32].…”

Section: Gene Expression That Did Not Respond To Changes In Feed Intakementioning

confidence: 99%

The expression of the gastrin/cholecystokinin (GAST/CCK) family and their receptors (CCKAR/CCKBR) in the chicken changes in response to quantitative restriction and reveals a functional role of CCK in the crop

Jiao

Wilson

Reid

et al. 2022

General and Comparative Endocrinology

View full text Add to dashboard Cite

Section: Gene Expression That Did Not Respond To Changes In Feed Intakementioning

confidence: 99%

The expression of the gastrin/cholecystokinin (GAST/CCK) family and their receptors (CCKAR/CCKBR) in the chicken changes in response to quantitative restriction and reveals a functional role of CCK in the crop

Jiao

Wilson

Reid

et al. 2022

General and Comparative Endocrinology

View full text Add to dashboard Cite

“…[13,16] The result was consistent with the previous study. [14,17] As the test method of gastric sensitivity requires longterm implantation of the balloon into the stomach of rats, the balloon is corroded by gastric acid in the stomach. This limited the valid time of test.…”

Section: Discussionmentioning

confidence: 99%

Multi-targeting regulation of auricular vagus nerve stimulation on gastric hypersensitivity and gastric dysmotility in a rodent model of functional dyspepsia

Rong¹,

Hou²,

Yang³

et al. 2022

Gut Microb Integr Wellness

View full text Add to dashboard Cite

Background: Evidences have shown the auricular vagus nerve stimulation (aVNS) is effective for functional dyspepsia (FD) recently. This study aimed to observe the mechanism of aVNS on facilitatory mediators of the inflammation in a rat model of functional dyspepsia. Methods: Thirty-six 5 d-old male Sprague Dawley rats were randomly divided into control groups (n = 12), model group (n = 12), aVNS group (n = 6) and sham-aVNS group (n = 6). Except for the control rats, all other rats were treated with iodoacetamide gavage. After the model was developed successfully, rats in aVNS group and sham-aVNS group received aVNS and sham-aVNS respectively, 30 min/1 time per day for 14 consecutive days. The control group and model group received no intervention. Gastric sensitivity after 1-week of intervention and gastric emptying after 2-week of intervention were adopted to assess the effect of aVNS. Brain-gut peptides, facilitatory mediators of the inflammation in serum were tested by ELISA, and α7 nicotinic acetylcholine receptor (α7-nAchR) in antrum tissue were tested by Immunohistochemistry to explore the mechanism of aVNS. Results: Compared with the control group, the gastric sensitivity was increased, gastric emptying decreased, and there was no structural damage in the gastric antrum in the model group. aVNS reduced visceral hypersensitivity and improved gastric emptying but not sham-aVNS. cholecystokinin, glucagon-like peptide-1, peptide, tumor necrosis factorα and interleukin 6 were all increased, while ghrelin and α7-nAchR decreased in model rats (P < 0.01 for all, compared with the control group). aVNS can normalize them. Conclusion: The aVNS can decrease the gastric sensitivity and increase gastric emptying, the mechanism was related to its regulation of brain-gut peptides and facilitatory mediators of the inflammation. The ameliorating effect was related to cholinergic mechanism.

show abstract

“…Studies on model organisms, ranging from yeast to mammals, have revealed that DR decreases insulin/insulin-like signalling (Bonkowski et al, 2006;Fontana et al, 2010;Klement & Fink, 2016). However, the effect of DR is specific to species, sex, age and mode of intervention (Bacon, 1986;Kewan et al, 2021;Luna-Castillo et al, 2022;Mellouk et al, 2018). For instance, in mammal models and humans, long-term DR reduces circulating IGF-1 levels (Fontana et al, 2008(Fontana et al, , 2016Lettieri-Barbato et al, 2016;Mitchell et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Sex‐specific effects of dietary restriction on physiological variables in Japanese quails

Reda,

Ndunguru,

Csernus

et al. 2024

Ecology and Evolution

View full text Add to dashboard Cite

Nutritional limitation is a common phenomenon in nature that leads to trade‐offs among processes competing for limited resources. These trade‐offs are mediated by changes in physiological traits such as growth factors and circulating lipids. However, studies addressing the sex‐specific effect of nutritional deficiency on these physiological variables are limited in birds. We used dietary restriction to mimic the depletion of resources to various degrees and investigated sex‐specific effects on circulating levels of insulin‐like growth factor 1 (IGF‐1) and triglycerides in Japanese quails (Coturnix japonica) subjected to ad libitum, 20%, 30% or 40% restriction of their daily requirement, for 2 weeks. We also explored the association of both physiological variables with body mass and egg production. While dietary restriction showed no effects on circulating IGF‐1, this hormone exhibited a marked sexual difference, with females having 64.7% higher IGF‐1 levels than males. Dietary restriction significantly reduced plasma triglyceride levels in both sexes. Females showed more than six‐fold higher triglyceride levels than males. Triglyceride levels were positively associated with body mass in females while showed not association in males. Overall, our findings revealed sex‐specific expression of physiological variables under dietary restriction conditions, which coincide with body size.

show abstract

Effects of fasting and re-feeding on the expression of CCK, PYY, hypothalamic neuropeptides, and IGF-related genes in layer and broiler chicks

Cited by 6 publications

References 59 publications

The expression of the gastrin/cholecystokinin (GAST/CCK) family and their receptors (CCKAR/CCKBR) in the chicken changes in response to quantitative restriction and reveals a functional role of CCK in the crop

The expression of the gastrin/cholecystokinin (GAST/CCK) family and their receptors (CCKAR/CCKBR) in the chicken changes in response to quantitative restriction and reveals a functional role of CCK in the crop

Multi-targeting regulation of auricular vagus nerve stimulation on gastric hypersensitivity and gastric dysmotility in a rodent model of functional dyspepsia

Sex‐specific effects of dietary restriction on physiological variables in Japanese quails

Contact Info

Product

Resources

About