The expression of the gastrin/cholecystokinin (GAST/CCK) family and their receptors (CCKAR/CCKBR) in the chicken changes in response to quantitative restriction and reveals a functional role of CCK in the crop

Jiao, Yuping; Wilson, Peter W.F.; Reid, Angus; Dunn, Ian C.

doi:10.1016/j.ygcen.2022.114024

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2023

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“…This finding is partially in accordance with an earlier study, in which chicken CCK1R is widely expressed in peripheral tissues (pancreas, small intestine, pituitary, and gallbladder; Ohkubo et al, 2007 ). Our findings also coincide with reports in mammals ( Kageyama et al, 2005 ; Konno et al, 2015 ), in which CCK2R is widely expressed in the peripheral tissues and is involved in the regulation of pancreatic enzyme secretion ( Suzuki et al, 2001 ), intestinal mobility ( Jiao et al, 2022 ), and satiety ( Weatherford et al, 1992 ; Dunn et al, 2013 ). Interestingly, our results showed that cCCK1R is expressed in the pituitary gland, which has not been reported in mammals thus far.…”

Section: Discussionsupporting

confidence: 92%