Effects of fasting on haematology and clinical chemistry values in the rat and dog

Matsuzawa, Toshiaki; Sakazume, Masashi

doi:10.1007/bf00798356

Cited by 46 publications

(37 citation statements)

References 11 publications

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“…These CAP/TAP-induced changes were considered to be the result of haemoconcentration and occurred in association with reduced diet and water consumption. Comparable changes in the blood of rats on limited diet and water consumptions have been described (Schwartz et al 1973;Boyne and Arthur 1990;Maejima and Nagase 1991;Zaporowska and Wasilewski 1991;Levin et al 1993), and similar findings were reported by Matsuzawa and Sakazume (1994) in the rat and dog.…”

Section: Discussionsupporting

confidence: 77%

Haemotoxicity of busulphan, doxorubicin, cisplatin and cyclophosphamide in the female BALB/c mouse using a brief regimen of drug administration

et al. 2010

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Many anticancer drugs are myelotoxic and cause bone marrow depression; however, generally, the marrow/blood returns to normal after treatment. Nevertheless, after the administration of some anti-neoplastic agents (e.g. busulphan, BU) under conditions as yet undefined, the marrow may begin a return towards normal, but normality may not be achieved, and late-stage/residual marrow injury may be evident. The present studies were conducted to develop a short-term mouse model (a 'screen') to identify late-stage/residual marrow injury using a brief regimen of drug administration. Female BALB/c mice were treated with BU, doxorubicin (DOX), cisplatin (CISPLAT) or cyclophosphamide (CYCLOPHOS) on days 1, 3 and 5. In 'preliminary studies', a maximum tolerated dose (MTD) for each drug was determined for use in 'main studies'. In main studies, mice were treated with vehicle (control), low and high (the MTD) dose levels of each agent. Necropsies were performed, and blood parameters and femoral/humeral nucleated marrow cell counts (FNCC/HNCC) were assessed on six occasions (from days 1 to 60/61 post-dosing). Late-stage/residual changes were apparent in BU-treated mice at day 61 post-dosing: RBC, Hb and haematocrit were reduced, mean cell volume/mean cell haemoglobin were increased and platelet and FNCC counts were decreased. Mice given DOX, CISPLAT and CYCLOPHOS, in general, showed no clear late-stage/residual effects (day 60/61). It was concluded that a brief regimen of drug administration, at an MTD, with assessment at day 60/61 post-dosing was a suitable short-term method/screen in the mouse for detecting late-stage/residual marrow injury for BU, a drug shown to exhibit these effects in man.

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Section: Discussionsupporting

confidence: 77%

Haemotoxicity of busulphan, doxorubicin, cisplatin and cyclophosphamide in the female BALB/c mouse using a brief regimen of drug administration

et al. 2010

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“…In this study, the serum BUN significantly decreased both in females and males and ALB decreased in male monkeys after fasting. These results of decreases in BUN concentrations were consistent with observations in dogs [13] and minipigs [21] with percentage changes of 51.6% and 38.7%, respectively. Unavailability of dietary protein intake during fasting leads to a decrease in serum BUN and ALB [1, 17].…”

Section: Discussionsupporting

confidence: 92%

“…In this study, no significant differences were observed between feed and fasting condition. The same results were observed in F344 rats and beagle dogs for GLU [13] and minipigs for TG [21]. Furthermore, replacing the current fasting blood samples with non‐fasting ones might improve cardiovascular disease–risk prediction by determination of TG [23].…”

Section: Discussionmentioning

confidence: 60%

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Effects of fasting on hematologic and clinical chemical values in cynomolgus monkeys (Macaca fascicularis)

Zeng

Yang

Pan

et al. 2010

J of Medical Primatology

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“…Decreases in MCV and MCH were associated with decreases in plasma erythropoietin (Epo) levels, (Naeshiro et al 1997). Epo is the principal physiological regulator of erythrocyte production and measuring the plasma Epo level is useful in evaluating anaemic conditions (Matsuzawa and Sakazume 1994). Although no attempt was made to assay Epo in this study, decreases in Hb and RBC indices indicate the presence of anaemia.…”

Section: Discussionmentioning

confidence: 87%

Secondary Amenorrhoea: Nutritional Anaemia a Cause or Reason

Raghuraman

Rathika

2001

Comparative Haematology International

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Nutritional deficiencies, menstrual irregularities and anaemia are commonly noticed among women in our population. To understand if nutritional anaemia could also be a contributing factor for secondary amenorrhoea (SA) in addition to various other factors known, a total of 50 patients, married and unmarried with SA of 3 months to 24 months duration were investigated for thyroid (T 3 , T 4 and thyroid-stimulating hormone (TSH), gonadotrophic hormones (luteinising hormone (LH), follicle-stimulating hormone (FSH) and prolactin), a few haematological parameters and serum protein, iron and total iron binding capacity (TIBC) levels. In these patients, uterine and ovarian factors were ruled out. Among these patients, thyroid dysfunction was seen in 46% of cases, whereas only 10% had LH, FSH and prolactin variations. Haematological studies revealed that the majority of these patients exhibited moderate to severe anaemia. From the estimation of serum protein, serum iron and TIBC levels the type of anaemia was found to be protein-iron deficiency anaemia (nutritional anaemia). These results conclude that hormonal factors apart from uterine and ovarian anamolies, need not be the main causes for SA and it was found that in the majority of the cases tested, SA was due to nutrition-related anaemia. In a few patients, it was noteworthy that the presence of anaemia along with thyroid disorder caused early onset of SA which was also of longer duration.

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Effects of fasting on haematology and clinical chemistry values in the rat and dog

Cited by 46 publications

References 11 publications

Haemotoxicity of busulphan, doxorubicin, cisplatin and cyclophosphamide in the female BALB/c mouse using a brief regimen of drug administration

Haemotoxicity of busulphan, doxorubicin, cisplatin and cyclophosphamide in the female BALB/c mouse using a brief regimen of drug administration

Effects of fasting on hematologic and clinical chemical values in cynomolgus monkeys (Macaca fascicularis)

Secondary Amenorrhoea: Nutritional Anaemia a Cause or Reason

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