Effects of ferulic acid on hematopoietic cell recovery in whole-body gamma irradiated mice

Abstract

These results suggest radioprotective efficacy by FA may be a result of early recovery of hematopoietic cells due to enhanced production of G-CSF and erythropoietin.

Radioprotective effects of dammarane sapogenins against 60Co‐induced myelosuppression in mice

“…Bone marrow is the most important hematopoietic organ and highly susceptible to irradiation injury, because it keeps a high rate of cell proliferation and composes different developmental stages of hematopoietic cells (Bentzen, ). Bone marrow injury can cause hematopoiesis suppression, resulting in low numbers of circulating blood cells and undesirable side effects such as anemia, bleeding, and infection (Ma et al, ; Simonnet et al, ). Radioprotective agents capable of improving myelosuppression with high efficacy and low toxicity are particularly important for radiation oncology.…”

“…Bone marrow is the most important hematopoietic organ and highly susceptible to irradiation injury, because it keeps a high rate of cell proliferation and composes different developmental stages of hematopoietic cells (Bentzen, 2006). Bone marrow injury can cause hematopoiesis suppression, resulting in low numbers of circulating blood cells and undesirable side effects such as anemia, bleeding, and infection (Ma et al, 2011;Simonnet et al, 2009) Normally, peripheral blood cell numbers maintain relative stability, depending on the proliferation and differentiation of HPC and HSC, which indirectly reflect the hematopoietic function of bone marrow (Carey, 2003). Radiation exposure causes injury in hematopoiesis and results in peripheral blood cell cytopenia, the decrease in mature RBC causes anemia, decreased PLT leads to bleeding, and decreased WBC results in infection (Liu et al, 2017;Whitnall et al, 2000).…”

“…Several compounds have been found to ameliorate hematopoietic injury, mediated via cytokines, prostaglandins, antioxidant vitamins, and melatonin (Arora et al, ; Ma et al, ). Haematopoietic growth factors (HGF) are used in cancer therapy, but these drugs may induce, for example, include skeleto‐muscular pain, arthralgia, or allergic reactions, which often limit the clinical applications of HGF (Geissler & Ganser, ; Gilmore, DePasquale, & Shadduck, ; Lutzky, Weber, Nunez, Gillett, & Spitler, ; Stern & Jones, ).…”

A Systems-Pharmacology Analysis of Herbal Medicines Used in Health Improvement Treatment: Predicting Potential New Drugs and Targets

“…Ferulic acid which interacts with SHP-2 and EP4 treatment enhanced hematopoietic progenitor cell activity resulting in accelerated blood cell recovery. Ferulic acid administration can increase the levels of granulocyte-colony stimulating factor (G-CSF) and erythropoietin [84]. These hemopoietic growth factors-related proteins play an important role in promoting hematopoietic progenitor cell proliferation and differentiation into mature blood cells.…”

Role of Radioprotectors in the Inhibition of DNA Damage and Modulation of DNA Repair After Exposure to Gamma-Radiation

“…When normal and tumor cells were treated with FA and the DNA damage measured after radiation exposure it was found that FA is having preferential protection to normal cells compared to tumor cells both under ex vivo and in vivo conditions . Recently, Ma et al have suggested that the radioprotective efficacy by FA may be a result of early recovery of hematopoietic cells due to enhanced production of G-CSF and erythropoietin (Ma et al 2011a). They have also reported that FA had a radioprotective effect through the ERK pathway to inhibit apoptosis and oxidation (Ma et al 2011b).…”