Effects of Fetal and Neonatal Renin-Angiotensin System Blockade in Lyon Hypertensive Rats

Florin, Marine; Sassard, J

doi:10.1097/00005344-199904000-00006

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…Such an hypothesis is favored by the observation that plasma renin is increased in young hypertensive rats and thereafter reduced in adult animals (23,27). However, the observation that in LH rats captopril given from conception to weaning was devoid of persistent effects on BP after its cessation (7) argues against this hypothesis. Nevertheless, because in LH rats the RAS was never blocked during the period of fast rise of BP (4 to 10 wk of age), we thought it of interest to determine whether a blockade of the RAS using an angiotensin-converting enzyme (ACE) inhibitor or an AT 1 receptor antagonist during this period might induce a BP decrease and a renoprotection that persist after treatment withdrawal.…”

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Differential evolution of blood pressure and renal lesions after RAS blockade in Lyon hypertensive rats

Bertram

Blanc-Brunat

Sassard

2002

American Journal of Physiology-Regulatory, Integrative and Comp

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The present work aimed to assess, in Lyon hypertensive (LH) rats, whether an early and prolonged inhibition of the renin-angiotensin system (RAS) could result in a blood pressure (BP) lowering and nephroprotection that persist after its withdrawal. Male LH rats received orally from 3 to 12 wk of age either an angiotensin-converting enzyme inhibitor perindopril at the doses of 0.4 and 3 mg x kg(-1) x day(-1) or an AT(1) receptor antagonist losartan at the dose of 10 mg x kg(-1) x day(-1). BP, histological changes in the kidney, and urinary protein excretion were examined during and 10 wk after cessation of the treatments. Both perindopril and losartan decreased BP, prevented renal lesions, and limited urinary protein excretion. After cessation of the treatment, BP returned to the level of never-treated LH rats in rats having received 3 mg x kg(-1) x day(-1) of perindopril while it remained slightly lower in those treated with 0.4 mg x kg(-1) x day(-1) of perindopril or with losartan. This lack of marked persistent antihypertensive effect contrasted with a durable decrease in urinary protein excretion and improvement of the renal histological lesions. In conclusion, it is possible to separate the BP-lowering effects of RAS blockade from those on glomerulosclerosis and urinary protein excretion.

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confidence: 99%

Differential evolution of blood pressure and renal lesions after RAS blockade in Lyon hypertensive rats

Bertram

Blanc-Brunat

Sassard

2002

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Bearing in mind these previous studies, we hypothesized that the brain RAS could be influenced by chronic prenatal and neonatal ACE inhibition and that this inhibition would impact the adult neural substrate of rats. Studies to test this hypothesis are feasible because ACE inhibitors can permeate the fetal–placental barrier and can be released into the milk 25,26 . Therefore, in the present study, we administered ACE inhibitors chronically during the prenatal and neonatal periods to investigate the nociceptive and anxiety status in adult male rats.…”

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Behavioural Changes Induced by Angiotensin‐converting Enzyme Inhibition During Pregnancy and Lactation in Adult Offspring Rats

Mecawi

Araujo

Fonseca

et al. 2009

Clin Exp Pharma Physio

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1. The use of angiotensin-converting enzyme (ACE) inhibitors during pregnancy is contraindicated because of their association with increased risks of fetopathy, including central nervous systems malformations. In addition, some reports have shown that renin-angiotensin system components are expressed differently during embryonic development and adulthood in the rat. 2. Because angiotensin II and its derivative peptides have been implicated in anxiety and modulation of nociception, the aim of the present study was to investigate whether inhibiting ACE during prenatal and neonatal periods would alter behavioural plasticity in adult male offspring rats. 3. Female Wistar rats were treated with captopril (2 mg/mL water; approximately 200 mg/kg per day) during pregnancy and lactation. At adulthood, the offspring were subjected to the open field, elevated plus maze, social interaction, forced swimming and tail flick tests. 4. Perinatal captopril treatment significantly increased ambulation (33%; P < 0.05) and decreased resting time (37.5%; P < 0.05) in the open field test. Perinatal captopril treatment did not alter any of the behavioural parameters of the elevated plus maze; however, captopril treatment did cause a significant increase in social interaction (75.3%; P < 0.05). In the forced swimming test, there was an increased latency period (102.9%; P < 0.001) and a decreased immobility period (38.7, P < 0.05) in rats treated with perinatal captopril. In the tail flick test, perinatal captopril treatment significantly reduced the latency time (26.3%; P < 0.01). 5. The data show that ACE inhibition during prenatal and neonatal periods affects behavioural responses in adult offspring rats, suggesting that ACE is required for the development of neural systems that are associated with adult anxiety and nociceptive behavioural responses.

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Ontogenetic role of angiontensin-converting enzyme in rats: Thirst and sodium appetite evaluation

Mecawi

Araujo

Rocha

et al. 2010

Physiology & Behavior

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We investigated the influence of captopril (an angiotensin converting enzyme inhibitor) treatment during pregnancy and lactation period on hydromineral balance of the male adult offspring, particularly, concerning thirst and sodium appetite. We did not observe significant alterations in basal hydromineral (water intake, 0.3M NaCl intake, volume and sodium urinary concentration) or cardiovascular parameters in adult male rats perinatally treated with captopril compared to controls. However, male offspring rats that perinatally exposed to captopril showed a significant attenuation in water intake induced by osmotic stimulation, extracellular dehydration and beta-adrenergic stimulation. Moreover, captopril treatment during perinatal period decreased the salt appetite induced by sodium depletion. This treatment also attenuated thirst and sodium appetite aroused during inhibition of peripheral angiotensin II generation raised by low concentration of captopril in the adult offspring. Interestingly, perinatal exposure to captopril did not alter water or salt intake induced by i.c.v. administration of angiotensin I or angiotensin II. These results showed that chronic inhibition of angiotensin converting enzyme during pregnancy and lactation modifies the regulation of induced thirst and sodium appetite in adulthood.

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Effects of Fetal and Neonatal Renin-Angiotensin System Blockade in Lyon Hypertensive Rats

Cited by 4 publications

References 23 publications

Differential evolution of blood pressure and renal lesions after RAS blockade in Lyon hypertensive rats

Differential evolution of blood pressure and renal lesions after RAS blockade in Lyon hypertensive rats

Behavioural Changes Induced by Angiotensin‐converting Enzyme Inhibition During Pregnancy and Lactation in Adult Offspring Rats

Ontogenetic role of angiontensin-converting enzyme in rats: Thirst and sodium appetite evaluation

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