Effects of fibrin on the integration hydroxyapatite coating implants: experimental study in a rabbit model

Protein-Based Hydroxyapatite Materials: Tuning Composition toward Biomedical Applications

“…These composites lead to a gradual increase in bone tissue over several months. , This behavior is consistent with observations of these type of composites many years after implanting, where ossification is observed. , The formed bone in implanted areas has a dense and homogeneous structure with a density similar to, or greater than, that of the adjacent biological bone . Also, HAp/Fibrin materials show an improvement in the osteogenic potential when compared to pure HAp and fibrin sealant. ,− The combination of HAp/Fibrin with other component, such as other proteins and cells, produces even better biological results. − …”

“…These materials are simple to produce since their synthesis only involves the mixture of the two components. In most of the published works, HAp/Fibrin glues are produced by mixing HAp (0.0005–0.008 g) with a fibrin glue (0.3–8 mL) to obtain an homogeneous composite − (Figure A). The fibrin glue is similar to a clot and essentially consists of fibrinogen, aprotinin, and thrombin.…”

“…The fibrin glue is similar to a clot and essentially consists of fibrinogen, aprotinin, and thrombin. Tisseel/Tissucol is the most used commercially available fibrin glue. ,,− …”

“…This composite shows significant osteogenic differentiation and when compared to conventional cell sheets presents better bone formation . Most biological studies conducted were performed in vivo , using Wistar rats, rabbits, chacma baboons, milk goats, and human patients. ,,− …”

Hybrid functionalized coatings on Metallic Biomaterials for Tissue Engineering

“…while promoting cell attachment and growth resulting in an intimate bonding between tissue and implant [318]. Gelatine Drug/cell delivery and tissue engineering [369] Bone tissue engineering, vascular stent, orthopaedic implant [370,371] Orthopedic implants [372,373] Elastin Tissue engineering [374] --Bone regeneration and dental implants [375] Fibrin Wound repair, tissue sealant, bone regeneration [376] --Bone tissue regeneration [377] Silk Bone, cartilage, and ligament regeneration [378] Bone tissue engineering, vascular stent [379][380][381] Bone tissue regeneration, Dentistry or orthopedics [382,383] The use of these polymers present limitations as a stand-alone coating strategy for metal substrates. While many biodegradable polymers, such as widely employed poly(lactic acid) (PLA) or poly(lactic-co-glycolic acid) (PLGA), have been shown to enhance corrosion resistance of metallic substrates [384], they undergo erosion by hydrolysis [385] and the corrosion control level they provide for biodegradable alloys as stand-alone coatings is insufficient.…”