Effects of Ficus hirta Vahl. (Wuzhimaotao) extracts on growth inhibition of HeLa cells

Zeng, You-wei; Liu, Xiaozhen; Lv, Zhencheng; Peng, Yun

doi:10.1016/j.etp.2011.01.009

Cited by 32 publications

(25 citation statements)

References 18 publications

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“…was investigated (Zeng et al 2012) and it was observed that different extracts affected cell viability and morphology. HeLa cells treated with the extracts showed sub-G1 phase increase analysed by flow cytometry.…”

Section: Phytoconstituents As Cell Cycle Inhibitorsmentioning

confidence: 99%

Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

et al. 2015

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Advancement in the field of cancer molecular biology has aided researchers to develop various new chemopreventive agents which can target cancer cells exclusively. Cancer chemopreventive agents have proficiency to inhibit, reverse and delay process of carcinogenesis during its early and later course. Chemopreventive agents can act as antioxidative, antimutagenic/antigenotoxic, anti-inflammatory agents or via aiming various molecular targets in a cell to induce cell death. Apoptosis is a kind of cell death which shows various cellular morphological alterations such as cell shrinkage, blebbing of membrane, chromatin condensation, DNA fragmentation, formation of apoptotic bodies etc. Nowadays, apoptosis is being one of the new approaches for the identification and development of novel anticancer therapies. For centuries, plants are known to play part in daily routine from providing food to management of human health. In the last two decades, diverse phytochemicals and various botanical formulations have been characterized as agents that possess potential to execute cancer cells via inducing apoptosis. Data obtained from the research carried out globally pointed out that natural products are the potential candidates which have capability to combat cancer. In the present review, we surveyed literature on natural products which throws light on the mechanism through which these phytochemicals induce apoptosis in cancer cells.

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Section: Phytoconstituents As Cell Cycle Inhibitorsmentioning

confidence: 99%

Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

et al. 2015

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“…Furthermore, compounds 1 and 2 had been isolated from other Ficus species (Kuete et al, 2008;Awad et al, 2012). In this study, small amounts of F. drupacea stem bark extract and isolated compounds exhibited higher anticancer activity against both HeLa and MCF-7 cancer cell lines compared to the use of tree latex of F. carica against esophageal cancer (Hashemi and Abediankenari, Table 3 In vitro antiproliferative activity [IC50 (g/ml)] of F. drupaceae L. n-hexane extract and 5-O-methyllatifolin (3), oleanolic acid (4), epifriedelanol (5), friedelin (6), epilupeol acetate (7) (Zeng et al, 2012). The antifungal and antibacterial activities of compounds 3 and 7 against a wide range of microorganisms found in this study were higher than those of commercial reagents and antibiotics; this has never been reported especially from F. drupacea.…”

Section: Anticancer Activitiesmentioning

confidence: 99%

“…The genus Ficus has a global distribution with approximately 800 species (Lansky and Paavilainen, 2011). The ethnopharmacological and economic values of the genus are also globally acknowledged as indicated by its multiple uses in traditional medicine across the globe (Gulecha and Sivakuma, 2011;Zeng et al, 2012;Kumar et al, 2013). Important biologically active molecules/compounds have been found in different organs of different Ficus species; e.g., sterols and triterpenes have been found in the root bark of Ficus chlamydocarpa, the stem bark of Ficus cordata (Kuete et al, 2008) and F. glomerata (Rahman et al, 1994), and in the leaf extracts of several Egyptian endemic Ficus species (Awad et al, 2012).…”

Section: Introductionmentioning

confidence: 97%

Antifungal, antibacterial and anticancer activities of Ficus drupacea L. stem bark extract and biologically active isolated compounds

Yessoufou

Elansary

Mahmoud

et al. 2015

Industrial Crops and Products

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“…A decrease in prostatespecific antigen secretion in athymic nude mice implanted with CWR22Rnu1 cells after treatment with lupeol, as well as inhibition of tumor growth suggest that lupeol may have a potential to be an effective agent against prostate cancer [17]. A previous study showed that the dry roots of Ficus hirta Vahl inhibited the growth of HeLa cells through induction of apoptosis [16]. In this study, a concentration-dependent increase in apoptotic PRST2-treated cells as shown by the incorporation of BrdU was observed 48 hours post-treatment with CE and CF extracts.…”

Section: Discussionmentioning

confidence: 99%

“…The chemo-preventive activity of Ficus species against renal carcinogenesis, human glioma and human hepatocellular carcinoma, HeLa cells, breast cancer cells, human nasopharyngeal carcinoma, oral epidermoid carcinoma KB and colorectal HT29 cancer cell lines have been reported [6,[14][15][16][17]. However, the study on the chemo-preventive property of the endemic Philippine tree Ficus pseudopalma (FP) has been limited to its effect on hepatocellular carcinoma HepG2 cell [8].…”

Section: Discussionmentioning

confidence: 99%