Effects of Fish Oil Supplementation on Platelet Survival and ex Vivo Platelet Function in Hypercholesterolemic Patients

Pirich, Christian; Gaszo, A.; Granegger, Susanne; Sinzinger, H.

doi:10.1016/s0049-3848(99)00103-6

Cited by 28 publications

(15 citation statements)

References 35 publications

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“…Supplementary fish oil has previously been shown to decrease both total and LDL-cholesterol in patients at risk of CVD [13,46], but this was not the case in our study of healthy volunteers taking relatively small dosages of tunafish oil. Larger doses or longer periods of supplementation may be necessary to see beneficial changes in lipid profile in healthy subjects.…”

Section: Discussioncontrasting

confidence: 91%

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Effects of Seal Oil and Tuna‐Fish Oil on Platelet Parameters and Plasma Lipid Levels in Healthy Subjects

Mann

O’Connell

Baldwin

et al. 2010

Lipids

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Fish are a rich source of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), two long-chain polyunsaturated n-3 fatty acids (LC n-3 PUFA) with cardiovascular benefits. A related but less-investigated LC n-3 PUFA, docosapentaenoic acid (DPA), is more common in seal oil and pasture-fed red meats. This study compared indicators of platelet function and plasma lipids in healthy volunteers given supplements containing these different fatty acids (FA) for 14 days. Subjects, randomised into three groups of ten, consumed capsules of tuna oil (210 mg EPA, 30 mg DPA, 810 mg DHA), seal oil (340 mg EPA, 230 mg DPA, 450 mg DHA) or placebo (sunola) oil. Supplementary LC n-3 PUFA levels were approximately 1 g/day in both fish and seal oil groups. Baseline dietary FA and other nutrient intakes were similar in all groups. Both fish and seal oil elevated platelet DHA levels (P < 0.01). Seal oil also raised platelet DPA and EPA levels (P < 0.01), and decreased p-selectin (P = 0.01), a platelet activation marker negatively associated with DPA (P = 0.03) and EPA (P < 0.01) but not DHA. Plasma triacylglycerol decreased (P = 0.03) and HDL-cholesterol levels increased (P = 0.01) with seal oil only. Hence, seal oil may be more efficient than fish oil at promoting healthy plasma lipid profiles and lowering thrombotic risk, possibly due to its high DPA as well as EPA content.

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Section: Discussioncontrasting

confidence: 91%

“…However, free LC n-3 PUFA in extracellular fluids appear to affect cardiac arrhythmias at doses of only 1 g/day [10]. In general intake of fish or use of fish oil supplement lowers CVD risk factors [12][13][14], apparently through the actions of eicosapentaenoic acid, C20:5n-3 (EPA), and docosahexaenoic acid, C22:6n-3 (DHA).…”

Section: Introductionmentioning

confidence: 99%

Effects of Seal Oil and Tuna‐Fish Oil on Platelet Parameters and Plasma Lipid Levels in Healthy Subjects

Mann

O’Connell

Baldwin

et al. 2010

Lipids

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“…It is well appreciated that n-3 fatty acids may modulate platelet 24,25 and monocyte functions 26 and that changes in the lipid composition of platelet and monocyte membranes reflect the dietary intake of n-3 fatty acids. 27 For this reason, it is likely that the incorporation of n-3 fatty acids in these cell types modifies membrane properties, such as stability and fluidity, 28 as well as cytosolic calcium concentration, protein localization and functionality in caveolae, 29 reducing cell activation and/or apoptosis, with this translating into lower MP release.…”

Section: Ed Mp Populations In Humansmentioning

confidence: 99%

Effect of the administration of n-3 polyunsaturated fatty acids on circulating levels of microparticles in patients with a previous myocardial infarction

Turco¹,

Basta²,

Lazzerini³

et al. 2008

Haematologica

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BackgroundIncreased levels of microparticles exposing tissue factor circulate in the blood of patients with coronary heart disease, possibly disseminating their pro-thrombotic and pro-inflammatory potential. Because diets rich in n-3 (polyunsaturated) fatty acids have been associated with reduced incidence of coronary heart disease-related events, we investigated the in vivo effects of treatments with n-3 fatty acids on levels of circulating microparticles and their tissue factor-dependent procoagulant activity in patients with a previous myocardial infarction.

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“…Fish oil increased platelet survival (P < 0.05) and lowered malondialdehyde formation. Platelet activation changes were associated with significant reductions in total cholesterol (-2.9%), LDL cholesterol (-3.5%), and triglycerides (-12.4%) [65].…”

Section: Fish N-3 Fatty Acidsmentioning

confidence: 99%

Functional foods and cardiovascular disease

Hasler

Kundrat

Wool

2000

Curr Atheroscler Rep

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Functional foods are foods that, by virtue of physiologically active food components, provide health benefits beyond basic nutrition. Many functional foods have been found to be potentially beneficial in the prevention and treatment of cardiovascular disease, the leading cause of mortality in the United States. These foods include soybeans, oats, psyllium, flaxseed, garlic, tea, fish, grapes, nuts, and stanol- and sterol ester enhanced margarine. When eaten in adequate amounts on a consistent basis, these foods may aid in decreasing the risk of cardiovascular disease by several potential mechanisms: lowering blood lipid levels, improving arterial compliance, reducing low-density lipoprotein oxidation, decreasing plaque formation, scavenging free radicals, and inhibiting platelet aggregation.

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Effects of Fish Oil Supplementation on Platelet Survival and ex Vivo Platelet Function in Hypercholesterolemic Patients

Cited by 28 publications

References 35 publications

Effects of Seal Oil and Tuna‐Fish Oil on Platelet Parameters and Plasma Lipid Levels in Healthy Subjects

Effects of Seal Oil and Tuna‐Fish Oil on Platelet Parameters and Plasma Lipid Levels in Healthy Subjects

Effect of the administration of n-3 polyunsaturated fatty acids on circulating levels of microparticles in patients with a previous myocardial infarction

Functional foods and cardiovascular disease

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