Functional foods and cardiovascular disease

Hasler, Clare M.; Kundrat, Susan; Wool, Deborah

doi:10.1007/s11883-000-0045-9

Cited by 87 publications

(44 citation statements)

References 68 publications

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“…In conclusion, there are no data available that functional foods supplemented with plant sterol esters reduce cardiovascular disease [56,57]. Patients affected by sitosterolemia whose levels of phytosterol are 20-25 higher than normal subjects, have an increased risk for cardiovascular disease [2].…”

Section: Discussionmentioning

confidence: 98%

Phytosterols, phytostanols and their esters: from natural to functional foods

Bacchetti

Masciangelo

Bicchiega

et al. 2011

Mediterr J Nutr Metab

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Phytosterols, phytostanols and their esters are a group of steroid alcohols that occur naturally in plants. As natural constituents of plant structures, phytosterols contribute to the regulation of the fluidity and permeability of cell membranes. They are found mostly in vegetable oils, fruits, nuts, cereals and legumes. The most abundant phytosterols are b-sitosterol, campesterol and stigmasterol. During the last 15 years the market for phytosterols, as dietary supplements, has lead to a rapidly growing worldwide market for functional foods containing phytosterols and stanols. Even though many different clinical trials have clearly demonstrated that phytosterols reduce LDL-cholesterol, it is unclear whether phytosterols have a positive effect on cardiovascular disease. Until now, there are no data related to the effect of phytosterol consumption on the development of cardiovascular diseases. This review focuses on the biochemistry of phytosterols, their metabolism and role in health and in pathological conditions.

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Section: Discussionmentioning

confidence: 98%

Phytosterols, phytostanols and their esters: from natural to functional foods

Bacchetti

Masciangelo

Bicchiega

et al. 2011

Mediterr J Nutr Metab

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“…A similar study with a vegetable drink with sardine protein hydrolysates significantly lowered BP by 8/5 mmHg in 13 wk [118] . Soy protein lowers BP in hypertensive patients in most studies [100,[119][120][121][122][123][124][125][126][127] . Soy protein intake was significantly and inversely associated with both SBP and DBP in 45694 Chinese women consuming 25 g/d or more of soy protein over 3 years and the association increased with age [119] .…”

Section: Proteinmentioning

confidence: 99%

“…The recent meta-analysis of 27 trials found a significant reduction in BP of 2.21/1.44 mmHg [120] . Some studies suggest improvement in endothelial function, improved arterial compliance, reduction in HS-CRP and inflammation, ACEI activity, reduction in sympathetic tone, diuretic action and reduction in both oxidative stress and aldosterone levels [125][126][127] .…”

Section: Proteinmentioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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“…Flax seed and straw can be used for both industrial and food products including a wide variety of nutraceuticals and health foods (Hasler, Kundrat, & Wool, 2000;Lemay, Dodin, Kadri, Jacques, & Forest, 2002;Ogborn, Nitschmann, Bankovic-Calic, Weiler, & Aukema, 2002;Watkins, Devitt, & S., 2001). For example, flax straw is an option for the production of certain composite materials (Morrison & Akin, 2001), while numerous health benefits have been associated with secoisolariciresinol diglucoside (SDG) lignans (Dodin et al, 2005;Hyvarinen et al, 2006) and omega-6 (linoleic acid, LA) and omega-3 (alpha linolenic acid, ALA) fatty acids found in flaxseed oils (Spence, Thornton, Muir, & Westcott, 2003;Watkins et al, 2001).…”

Section: Introductionmentioning

confidence: 99%