Effects of fission neutrons on human thyroid tissues maintained in SCID mice

Adachi, Souichi; Ryo, Haruko; Hongyo, Tadashi; Nakajima, Hiroo; Tsuboi-Kikuya, Rie; Tokita, Yoriko; Matsuzuka, Fumio; Hiramatsu, Keizo; Fujikawa, Kazuo; Itoh, Takeshi; Nomura, Taisei

doi:10.1016/j.mrgentox.2009.12.017

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…Interestingly, genes identified as participants in the response of the non-tumorigenic human thyroid epithelial cell line Htori-3 to high-linear energy transfer particles [45], in the human thyroid papillary carcinoma cell line TPC-1 to various doses of X-rays [46], or as participants in the specific response of human thyroid tissue transplanted in SCID mice to 137 Cs or neutrons [47], are also found deregulated in radiation-induced thyroid tumors both in post-Chernobyl and post-radiotherapy series and may be markers of radiation exposure whatever the dose, dose rate, external radiation or internal contamination (Supplementary table). …”

Section: Are Specific Molecular Pathways Deregulated In Radiation-mentioning

confidence: 99%

Discriminating Gene Expression Signature of Radiation-Induced Thyroid Tumors after Either External Exposure or Internal Contamination

Ory¹,

Ugolin²,

Schlumberger

et al. 2011

Genes

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Both external radiation exposure and internal radionuclide contamination are well known risk factors in the development of thyroid epithelial tumors. The identification of specific molecular markers deregulated in radiation-induced thyroid tumors is important for the etiological diagnosis since neither histological features nor genetic alterations can discriminate between sporadic and radiation-induced tumors. Identification of highly discriminating markers in radiation-induced tumors is challenging as it relies on the ability to identify marker deregulation which is associated with a cellular stress that occurred many years before in the thyroid cells. The existence of such a signature is still controversial, as it was not found in several studies while a highly discriminating signature was found in both post-radiotherapy and post-Chernobyl series in other studies. Overall, published studies searching for radiation-induced thyroid tumor specificities, using transcriptomic, proteomic and comparative genomic hybridization approaches, and bearing in mind the analytical constraints required to analyze such small series of tumors, suggest that such a molecular signature could be found. In comparison with sporadic tumors, we highlight molecular similarities and specificities in tumors occurring after high-dose external radiation exposure, such as radiotherapy, and in post-Chernobyl tumors that occurred after internal 131I contamination. We discuss the relevance of signature extrapolation from series of tumors developing after high and low doses in the identification of tumors induced at very low doses of radiation.

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Section: Are Specific Molecular Pathways Deregulated In Radiation-mentioning

confidence: 99%

Discriminating Gene Expression Signature of Radiation-Induced Thyroid Tumors after Either External Exposure or Internal Contamination

Ory¹,

Ugolin²,

Schlumberger

et al. 2011

Genes

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show abstract

“…Those other characteristics also make it possible to obtain PDX on a tissue-by-tissue basis. 5,6) The Super SCID-PDX model was initially developed to assess various toxicities for chemicals and ionizing radiation as reported by Nomura [7][8][9] and has also been used in the development of marketed drugs. Recently, our gastric cancer PDX was used in preclinical studies for trastuzumab deruxtecan, a treatment for HER2-positive gastric and breast cancer, and the drug was launched in 2020.…”

Section: Introductionmentioning

confidence: 99%

The Tumor Growth Inhibitory Effect of a Standardized Extract of Cultured <i>Lentinula edodes</i> Mycelia Using Patient Derived Xenograft Model

Yoshii,

Adachi,

Ryo

et al. 2024

Biological & Pharmaceutical Bulletin

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Patient derived xenograft (PDX) is a powerful tool to confirm pharmacological efficacy in non-clinical studies for the development of various drugs including anti-cancer agents and therapeutic research. A standardized extract of cultured Lentinula edodes mycelia, a product name AHCC ® is produced by Amino Up Co., Ltd. (Sapporo, Japan). In this study, we investigated the inhibitory effect of AHCC ® on the growth of tumor PDX in Super SCID (severe combined immunodeficiency) mice. Effects of AHCC ® and BCG administration on the growth of renal cancer PDX implanted in Super SCID mice were evaluated by PDX growth curve. Tendency for the effects on the growth of renal cancer PDX in Super SCID by administration of AHCC ® and BCG before implanting the PDX were demonstrated. The effects of the oral administration of AHCC ® on the growth of renal, invasive and non-invasive breast cancer PDX in Super SCID mice were studied. In Super SCID mice transplanted with renal cancer PDX, AHCC ® significantly suppressed tumor proliferation from the day 48 to 83 after transplantation. In two types of breast cancer PDX, tendency of the growth inhibitory effects of AHCC ® were shown by PDX growth curve. Significant inhibitory effect was found at only one time point for during proliferation in each PDX. Super SCID-PDX model has the potential to be a useful tool to investigate for the effect of functional foods. Key words patient derived xenograft (PDX), standardized extract of cultured Lentinula edodes mycelia (ECLM), functional food, renal cancer, breast cancer, severe combined immunodeficient (SCID)

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Histopathological characteristics of human non-tumor thyroid tissues in a long-term model of adenomatous goiter xenografts in the NOD/Shi-scid, IL-2Rγnull mouse

Fujii¹,

Kato²,

Chen³

et al. 2014

Experimental and Toxicologic Pathology

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Effects of fission neutrons on human thyroid tissues maintained in SCID mice

Cited by 6 publications

References 15 publications

Discriminating Gene Expression Signature of Radiation-Induced Thyroid Tumors after Either External Exposure or Internal Contamination

Discriminating Gene Expression Signature of Radiation-Induced Thyroid Tumors after Either External Exposure or Internal Contamination

The Tumor Growth Inhibitory Effect of a Standardized Extract of Cultured <i>Lentinula edodes</i> Mycelia Using Patient Derived Xenograft Model

Histopathological characteristics of human non-tumor thyroid tissues in a long-term model of adenomatous goiter xenografts in the NOD/Shi-scid, IL-2Rγnull mouse

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