Effects of flaxseed(Linum usitatissimum) chutney on gamma-glutamyl transpeptidase and micronuclei profile in azoxymethane treated rats

Shakir, K. A. Faseehuddin; Madhusudhan, Basavaraj

doi:10.1007/bf02913330

Cited by 8 publications

(2 citation statements)

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“…However, a review of literature revealed that none of the herbal medications that patient 1 had taken (Lineum usitatissimum, Fumariaceae, Curcumin, and Silybum marianum) are known to cause a liver damage; in fact, several recent studies have shown a protective effect of these medications in states of liver injury. [21][22][23][24] Nevertheless, no study examined the combination of these herbal medications, thus, potential liver toxicity cannot be excluded. As to the second patient who was treated with fluconazole, although LFT abnormalities are associated with all of the azoles, these abnormalities are more likely with itraconazole and ketoconazole than with fluconazole 25,26 and the later seems to have a lower risk of treatment discontinuation because of adverse events.…”

Section: Discussionmentioning

confidence: 99%

Acute Liver Injury during Co-treatment with Levetiracetam and Temozolomide

Chen¹,

Mizrahi²,

Nubani³

et al. 2015

Liver Res Open J

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Citation ABSTRACTDrug-induced liver injury (DILI) accounts for approximately 10 percent of all cases of acute hepatitis. The patterns of acute injury include any form of hepatic injury, but the most common problems are cholestasis, hepatocellular damage, or a mixed type. DILI is often reversible, and discontinuation of the offending agent usually results in a complete recovery; however, some cases may lead to chronic liver injury, cirrhosis, and even death. Temozolomide (TMZ) is an alkylating, anti-neoplastic agent used for the treatment of refractory anaplastic astrocytoma, newly-diagnosed Glioblastoma multiforme (GBM) and metastatic melanoma. Levetiracetam (LEV) is an established second-generation antiepileptic drug and is most commonly approved as adjunctive treatment of partial-onset seizures with or without secondary generalization. When administered separately each of these drugs is considered to be relatively safe and only few cases of severe liver injury can be found throughout the literature; however, LEV and TMZ are commonly used together in the treatment of brain malignancies. We report three patients who presented with jaundice during treatment with TMZ and LEV, and propose a mechanism for liver sensitization by LEV for TMZ-induced injury.

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Section: Discussionmentioning

confidence: 99%

Acute Liver Injury during Co-treatment with Levetiracetam and Temozolomide

Chen¹,

Mizrahi²,

Nubani³

et al. 2015

Liver Res Open J

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“…People have been consuming flaxseeds since ancient times. In India, flaxseeds are still being consumed as food and also for medicinal purposes [19]. It has an important position among oilseeds because of its versatility.…”

Section: Flaxmentioning

confidence: 99%

Impact of Vitamins and Minerals Enriched Flora in the Management of Calciphytoliths: A Special Focus on Vitamin E

Govindan¹,

Tilak²,

Sivaramakumar³

et al. 2021

Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects

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Calciphytoliths (calcium oxalate calculi) have a great influence on human health and are a disease with a high likelihood of recurrence at a rate of more than 10% within a year. Plant flavonoids, saponins, and tannins are reported to be Litholytic by inhibiting calcium oxalate crystals or by their calcium channel blocking activity. Vitamins and minerals containing flora completely prevent deposition of oxalate by preventing pre-oxidation injury and restoring renal tissue antioxidants. So vitamin therapy also might protect against oxalate calculi deposition in the human kidneys. The present chapter discusses the impact of vitamins especially vitamin E, calcium, and low oxalate-containing plants for the management of various urinary or kidney disorders.

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