Effects of fluoxetine and d-fenfluramine on cocaine-seeking behavior in rats

Burmeister, J; Lungren, Erin M.; Neisewander, Janet L.

doi:10.1007/s00213-002-1307-8

Cited by 68 publications

(59 citation statements)

References 42 publications

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“…Consistent with our previous research (Burmeister et al, 2003), d-fenfluramine attenuated cue reinstatement, and this effect was reversed by SB 242,084. Previous research has shown that SB 242,084 does not alter basal locomotor activity (Fletcher et al, 2002b), but does potentiate d-fenfluramine-induced hyperactivity (Higgins et al, 2001).…”

Section: Discussionsupporting

confidence: 91%

“…The present study also examined whether the respective antagonists could reverse the d-fenfluramine-induced attenuation of cue-elicited reinstatement that we reported previously (Burmeister et al, 2003).…”

Section: Introductionmentioning

confidence: 85%

“…), with order of the two conditions counterbalanced. The preadministration intervals were chosen based on previous studies examining cocaine-mediated behaviors (Schenk, 2000;Fletcher et al, 2002a;Munzar et al, 2002;Burmeister et al, 2003). To initiate testing, one passive presentation of the cocaine-paired stimulus complex (ie lights, tone, and pump motor) was given.…”

Section: Cue Reinstatement Testingmentioning

confidence: 99%

“…Manipulations that decrease 5-HT neurotransmission attenuate cue-elicited reinstatement of cocaine-seeking behavior, but enhance cocaine-primed reinstatement of cocaine-seeking behavior (Tran-Nguyen et al, 1999. Paradoxically, manipulations that increase 5-HT neurotransmission, such as the indirect agonists fluoxetine or d-fenfluramine, also attenuate cueelicited reinstatement of cocaine-seeking behavior, but do not reliably alter cocaine-primed reinstatement of cocaineseeking behavior (Baker et al, 2001;Burmeister et al, 2003). The nonselective 5-HT 2 receptor antagonist, ritanserin, fails to alter cocaine-primed reinstatement of cocaine-seeking behavior (Schenk, 2000); however, more selective 5-HT 2 receptor antagonists have provided opposing results.…”

Section: Introductionmentioning

confidence: 99%

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Differential Roles of 5-HT Receptor Subtypes in Cue and Cocaine Reinstatement of Cocaine-Seeking Behavior in Rats

Burmeister

Lungren

Kirschner

et al. 2003

Neuropsychopharmacol

101

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The 5-HT indirect agonist, d-fenfluramine, attenuates cue reinstatement of extinguished cocaine-seeking behavior. To investigate the role of 5-HT receptor subtypes in this effect, we examined whether the attenuation is reversed by either a 5-HT 1A , 5-HT 2A/C , or 5-HT 2C receptor antagonist. We also examined the effects of the antagonists alone on both cue and cocaine-primed reinstatement. Rats that had been trained to press a lever for cocaine (0.75 mg/kg/0.1 ml, i.v.) paired with light and tone cues underwent daily extinction sessions during which responding had no consequences. We then examined the effects of WAY 100635 (0-1.0 mg/kg, s.c.), ketanserin (0-10.0 mg/kg, i.p.), or SB 242,084 (0-1.0 mg/kg, i.p.) with and without d-fenfluramine (1.0 mg/kg, i.p.) pretreatment on cue reinstatement. Subsequently, we examined the effects of the antagonists on cocaine-primed (7.5 or 15.0 mg/kg, i.p.) reinstatement. The 5-HT 1A antagonist, WAY 100635, failed to alter cue reinstatement, but attenuated cocaine reinstatement. Conversely, the 5-HT 2A/C antagonist, ketanserin, attenuated cue reinstatement, but failed to alter cocaine reinstatement. The 5-HT 2C -selective antagonist, SB 242,084, did not alter cue or cocaine reinstatement, but was the only drug that reversed the d-fenfluramine-induced attenuation of cue reinstatement. The findings suggest that stimulation of 5-HT 1A receptors plays a critical role in cocaine-primed, but not cue, reinstatement. Furthermore, 5-HT 2A and 5-HT 2C receptors may play oppositional roles in cue reinstatement. The SB 242,084 reversal of the d-fenfluramine attenuation suggests that stimulation of 5-HT 2C receptors inhibits cue reinstatement, whereas the ketanserin-induced attenuation of cue reinstatement suggests that decreased stimulation of 5-HT 2A receptors inhibits this behavior.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 85%

Section: Cue Reinstatement Testingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Differential Roles of 5-HT Receptor Subtypes in Cue and Cocaine Reinstatement of Cocaine-Seeking Behavior in Rats

Burmeister

Lungren

Kirschner

et al. 2003

Neuropsychopharmacol

101

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“…Treatment with dexfenfluramine reduces responding for a CRf (Fletcher, 1995;Wilson et al, 2000), while whole-brain 5-HT neuron ablation enhances this behavior (Fletcher et al, 1999). In tests of drug-seeking behavior, dexfenfluramine and the SSRI fluoxetine also diminished the ability of a cocaine-paired stimulus to reinstate responding under extinction conditions (Baker et al, 2001;Burmeister et al, 2003). Furthermore, we have recently shown that another SSRI, citalopram, reduced responding for a CRf and a USRf (Browne et al, 2016).…”

Section: Introductionmentioning

confidence: 93%

Decreased Incentive Motivation Following Knockout or Acute Blockade of the Serotonin Transporter: Role of the 5-HT2C Receptor

Browne

Fletcher

2016

Neuropsychopharmacol

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Acute pharmacological elevation of serotonin (5-hydroxytryptamine; 5-HT) activity decreases operant responding for primary reinforcers, suggesting that 5-HT reduces incentive motivation. The mechanism by which 5-HT alters incentive motivation is unknown, but parallel evidence that 5-HT 2C receptor agonists also reduce responding for primary reinforcers implicates this receptor as a potential candidate. These experiments examined whether chronic and acute disruptions of serotonin transporter (SERT) activity altered incentive motivation, and whether the 5-HT 2C receptor mediated the effects of elevated 5-HT on behavior. To assess incentive motivation, we measured responding for three different reinforcers: a primary reinforcer (saccharin), a conditioned reinforcer (CRf), and an unconditioned sensory reinforcer (USRf). In the chronic condition, responding was compared between SERT knockout (SERT-KO) mice and their wild-type littermates. In the acute condition, responding was examined in wild-type mice following treatment with 10 or 20 mg/kg citalopram, or its vehicle. The ability of the selective 5-HT 2C antagonist SB 242084 to prevent the effects of SERT-KO and citalopram on responding was subsequently examined. Both SERT-KO and citalopram reduced responding for saccharin, a CRf, and a USRf. Treatment with SB 242084 enhanced responding for a CRf and a USRf in SERT-KO mice and blocked the effects of citalopram on CRf and USRf responding. However, SB 242084 was unable to prevent the effects of SERT-KO or citalopram on responding for saccharin. These results support a powerful inhibitory function for 5-HT in the control of incentive motivation, and indicate that the 5-HT 2C receptor mediates these effects of 5-HT in a reinforcer-dependent manner.

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Relationship of prolactin response to meta‐chlorophenylpiperazine with severity of drug use in cocaine dependence

Patkar

Mannelli

Hill

et al. 2006

Human Psychopharmacology

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Effects of fluoxetine and d-fenfluramine on cocaine-seeking behavior in rats

Abstract: These findings suggest that 5-HT indirect agonists effectively attenuate cocaine-seeking behavior elicited by cocaine-associated stimuli, but are much less effective in attenuating cocaine-seeking behavior elicited by cocaine priming.

Cited by 68 publications

References 42 publications

Differential Roles of 5-HT Receptor Subtypes in Cue and Cocaine Reinstatement of Cocaine-Seeking Behavior in Rats

Differential Roles of 5-HT Receptor Subtypes in Cue and Cocaine Reinstatement of Cocaine-Seeking Behavior in Rats

Decreased Incentive Motivation Following Knockout or Acute Blockade of the Serotonin Transporter: Role of the 5-HT2C Receptor

Relationship of prolactin response to meta‐chlorophenylpiperazine with severity of drug use in cocaine dependence

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