Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea

Chen, Huihui; Zha, Jinmiao; Yuan, Lilai; Wang, Zijian

doi:10.1016/j.chemosphere.2014.08.062

Cited by 76 publications

(24 citation statements)

References 49 publications

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“…On the contrary, others have found down-regulation of these genes (e.g. Chen et al, 2015;Gonzalez-Rey et al, 2014;Sun et al, 2014). These differences may be attributed to the particular conditions of each experiment, to the pollutant and to the tested species.…”

Section: Resultsmentioning

confidence: 81%

Evaluation of the estrogenic and oxidative stress effects of the UV filter 3-benzophenone in zebrafish (Danio rerio) eleuthero-embryos

Rodrı́guez-Fuentes

Sandoval-Gío

Arroyo-Silva

et al. 2015

Ecotoxicology and Environmental Safety

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Section: Resultsmentioning

confidence: 81%

Evaluation of the estrogenic and oxidative stress effects of the UV filter 3-benzophenone in zebrafish (Danio rerio) eleuthero-embryos

Rodrı́guez-Fuentes

Sandoval-Gío

Arroyo-Silva

et al. 2015

Ecotoxicology and Environmental Safety

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“…On another hand, A. woodiana also adjust it's antioxidant ability by enhancing antioxidant enzyme expression to eliminate ROS. If generation of ROS are under a weak level, anti-oxidant enzyme expressions should be up-regulated that contribute to endure oxidative stresses [25,26,39,44]. Once the production of ROS is exceed the eliminating ability of cells that cause a shift between oxidants and antioxidants in favor of oxidants, and result in chronic inflammation, apoptosis In the PBDE-209 treated groups, up-regulations of AwSOD and AwCAT expression exhibited a time-and dose-dependent pattern.…”

Section: Discussionmentioning

confidence: 99%

“…Orchestra of anti-oxidant enzymes is a key hallmark of organism homeostasis. Moderate oxidative stress in a shorter time may function as an important player to induce different anti-oxidant enzyme expressions to deal with different ROS [25,26,43].…”

Section: Discussionmentioning

confidence: 99%

“…This event is performed by antioxidant enzymes system including superoxide dismutase (SOD), catalase (CAT), selenium-dependent glutathione peroxidase, glutathione S-transferase and metallothionein. SOD catalyzes the conversion of superoxide radicals to hydrogen peroxide and divalent oxygen, then CAT catalyze the reduction of hydrogen peroxide [25,26]. SOD and CAT have been considered as biomarkers of exposure for environmental monitoring programs.…”

Section: Introductionmentioning

confidence: 99%

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Molecular cloning, characterization, and the response of Cu/Zn superoxide dismutase and catalase to PBDE-47 and -209 from the freshwater bivalve Anodonta woodiana

Xia

Huang

Zhang

et al. 2016

Fish & Shellfish Immunology

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a b s t r a c tPolybrominated diphenyl ethers-47 (PBDE-47) and -209 are significant components of total PBDEs in water and can catalyze the production of reactive oxygen species (ROS) in the organisms. Anti-oxidant enzymes play an important role in scavenging the high level of ROS. In the current study, two fulllength cDNAs of Cu/Zn superoxide dismutase (CuZnSODs) and catalase (CAT) were isolated from freshwater bivalve Anodonta woodiana by rapid amplification of cDNA ends approach and respectively named as AwSOD and AwCAT. The nucleotide sequence of AwSOD cDNA had an open reading frame (ORF) of 465 bp encoding a polypeptide of 155 amino acids in which signature 1 GKHGFHVHEFGDNT and signature 2 GNAGARSACGVI of SODs were observed. Deduced amino acid sequence of AwSOD showed a significant similarity with that of CuZnSODs. AwCAT had an ORF 1536 bp encoding a polypeptide of 512 amino acids which contains a conserved catalytic site motif, and a proximal heme-ligand signature motif of CATs. The time-course expressions of AwSOD and AwCAT in hepatopancreas were measured by quantitative real-time PCR. Expressions of AwSOD and AwCAT showed a significant up-regulation in groups at a low concentration treatment of PBDE-47, a biphasic pattern in groups with a high concentration treatment. Administration of PBDE-209 could result in an up-regulation of AwSOD and AwCAT expressions with time-and dose-dependent matter. These results indicate that up-regulations of AwSOD and AwCAT expression of hepatopancreas of freshwater bivalve A. woodiana contribute to eliminate oxidative stress derived from PBDE-47 and -209 treated.

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“…In the same crab species, 120 μg/L of fluoxetine significantly altered locomotor behaviors (Mesquita, Guilhermino, & Guimaraes, 2011). Several other studies have demonstrated that fluoxetine leads to adverse physiological and behavioral outcomes in aquatic organisms that could alter their functional roles within the community (Bossus, Guler, Short, Morrison, & Ford, 2014; Chen, Zha, Yuan, & Wang, 2015; Dzieweczynski & Hebert, 2012; Munari, Marin, & Matozzo, 2014; Peters & Granek, 2016; Schultz et al., 2011). …”

Section: Introductionmentioning

confidence: 99%

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Peters

Granek

Rivera

et al. 2017

Ecology and Evolution

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Predators exert considerable top‐down pressure on ecosystems by directly consuming prey or indirectly influencing their foraging behaviors and habitat use. Prey is, therefore, forced to balance predation risk with resource reward. A growing list of anthropogenic stressors such as rising temperatures and ocean acidification has been shown to influence prey risk behaviors and subsequently alter important ecosystem processes. Yet, limited attention has been paid to the effects of chronic pharmaceutical exposure on risk behavior or as an ecological stressor, despite widespread detection and persistence of these contaminants in aquatic environments. In the laboratory, we simulated estuarine conditions of the shore crab, Hemigrapsus oregonensis, and investigated whether chronic exposure (60 days) to field‐detected concentrations (0, 3, and 30 ng/L) of the antidepressant fluoxetine affected diurnal and nocturnal risk behaviors in the presence of a predator, Cancer productus. We found that exposure to fluoxetine influenced both diurnal and nocturnal prey risk behaviors by increasing foraging and locomotor activity in the presence of predators, particularly during the day when these crabs normally stay hidden. Crabs exposed to fluoxetine were also more aggressive, with a higher frequency of agonistic interactions and increased mortality due to conflicts with conspecifics. These results suggest that exposure to field‐detected concentrations of fluoxetine may alter the trade‐off between resource acquisition and predation risk among crabs in estuaries. This fills an important data gap, highlighting how intra‐ and interspecific behaviors are altered by exposure to field concentrations of pharmaceuticals; such data more explicitly identify potential ecological impacts of emerging contaminants on aquatic ecosystems and can aid water quality management.

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Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea

Cited by 76 publications

References 49 publications

Evaluation of the estrogenic and oxidative stress effects of the UV filter 3-benzophenone in zebrafish (Danio rerio) eleuthero-embryos

Evaluation of the estrogenic and oxidative stress effects of the UV filter 3-benzophenone in zebrafish (Danio rerio) eleuthero-embryos

Molecular cloning, characterization, and the response of Cu/Zn superoxide dismutase and catalase to PBDE-47 and -209 from the freshwater bivalve Anodonta woodiana

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

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