Effects of food supplements on periodontal status and local and systemic inflammation after nonoperative periodontal treatment

Rasperini, Giulio; Pellegrini, G; Sugai, Jim; Mauro, Cesare; Fiocchi, Simone; Mora, P. Corvi; Dellavia, Claudia

doi:10.2334/josnusd.18-0048

Cited by 11 publications

(9 citation statements)

References 37 publications

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“…As the protein level decreased, there was also a decrease in the number of TRAP-positive cells. Supporting these results, Rasperini et al [ 38 ] evaluated the effects of dietary supplementation on periodontal clinical parameters and systemic inflammatory markers in patients with severe CP. Supragingival debridement was performed, and periodontal clinical parameters were monitored and correlated with both serum C-reactive protein and MMP levels.…”

Section: Discussionmentioning

confidence: 91%

Systemic and local effects of doxycycline and low-intensity laser treatment on periodontitis in rats

Silveira

Lima

Cintra

et al. 2022

J Periodontal Implant Sci

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Purpose This study evaluated the systemic and local effects of doxycycline (DOX) and low-intensity laser (LIL) treatment as adjuvants to scaling and root planing (SRP) in the treatment of experimental periodontitis in rats. Methods The sample consisted of 180 male rats ( Rattus norvegicus albinus , Wistar), of which 30 did not receive induction of periodontal disease (negative control [NC] group) and 150 received induction of periodontal disease in the lower first molar. After 7 days, the ligature was removed, and the animals were divided into the following groups: NT (no treatment), SRP (SRP), DOX (SRP and DOX irrigation), LIL (SRP and laser irradiation), and DOX+LIL (SRP, DOX, and LIL). The animals were euthanized at 7, 15, and 30 days; thereafter, biochemical, radiographic, histological, and immunohistochemical analyses were performed. Results In the intragroup analysis, lower concentrations of α-1-glycoprotein acid (α-1-Ga) and complement 3 (C3) were observed in the DOX+LIL group than in all other groups at all time points, as well as lower levels of complement 4 (C4) at 15 and 30 days ( P <0.001). Less bone loss was observed in the DOX, LIL, and DOX+LIL groups than in the NC and SRP groups at all time points ( P <0.001). There was a smaller number of tartrate-resistant acid phosphatase (TRAP)-positive cells in the DOX+LIL group than in the other groups at all time points ( P <0.001). Positive correlations were observed between the systemic levels of α-1-Ga, C3, and C4 and the number of TRAP-positive cells. Conclusions The combination of DOX with LIL as SRP adjuvants was effective both systemically and locally for the treatment of experimental periodontitis in rats.

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Section: Discussionmentioning

confidence: 91%

Systemic and local effects of doxycycline and low-intensity laser treatment on periodontitis in rats

Silveira

Lima

Cintra

et al. 2022

J Periodontal Implant Sci

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show abstract

“…As protein decreased, there was also a decrease in BL area. Supporting these results, Rasperini et al (2019) (44) evaluated the effects of a dietary supplement on periodontal clinical parameters and systemic inflammatory markers in patients with severe chronic periodontitis. Supragingival debridement was performed, and periodontal clinical parameters were monitored and correlated with serum C-reactive protein (CRP) and matrix metalloproteinase.…”

Section: Discussionmentioning

confidence: 91%

Influence of Doxycycline and InGaAlP Diode Laser at 660 nm Wavelength in the Treatment of Periodontitis Induced in Rats: In Vivo Study

Silveira

Lima

Cintra

et al. 2021

Photochem & Photobiology

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“…CRP serum levels were reduced after 3 months in both groups, but not enough to reach statistical significance. Overall, even though micronutrients are suspected to provide a beneficial effect on periodontal tissues by reducing inflammation and damage due to inflammatory diseases [ 97 ], MD did not affect local and systemic inflammatory parameters, except for a slight decrease in MMP saliva levels [ 90 ].…”

Section: How We Can Reduce the Effect Of Periodontal Treatment On Sys...mentioning

confidence: 99%

Managing the Systemic Impact of Periodontitis

et al. 2022

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Periodontitis is a microbially driven host-mediated disease that leads to loss of periodontal attachment and bone. It is associated with elevation of systemic inflammatory markers and with the presence of systemic co-morbidities. Furthermore, periodontal treatment leads to a 24–48 h-long acute local and systemic inflammatory response. This systemic response might increase the burden of patients with compromised medical history and/or uncontrolled systemic diseases. The correlation between periodontitis and systemic diseases, the impact of periodontitis on the quality of life and public health, the effects of periodontal treatment on systemic health and disease, and the available methods to manage systemic inflammation after periodontal therapy are discussed. The main focus then shifts to a description of the existing evidence regarding the impact of periodontitis and periodontal treatment on systemic health and to the identification of approaches aiming to reduce the effect of periodontitis on systemic inflammation.

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Effects of food supplements on periodontal status and local and systemic inflammation after nonoperative periodontal treatment

Cited by 11 publications

References 37 publications

Systemic and local effects of doxycycline and low-intensity laser treatment on periodontitis in rats

Systemic and local effects of doxycycline and low-intensity laser treatment on periodontitis in rats

Influence of Doxycycline and InGaAlP Diode Laser at 660 nm Wavelength in the Treatment of Periodontitis Induced in Rats: In Vivo Study

Managing the Systemic Impact of Periodontitis

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