Effects of fresh mango consumption on cardiometabolic risk factors in overweight and obese adults

Rosas, Martin; Pinneo, Sherry; O'Mealy, Celéste; Tsang, Michelle; Liu, Changqi; Kern, Mark; Hooshmand, Shirin; Hong, Mee Young

doi:10.1016/j.numecd.2021.11.001

Cited by 10 publications

(13 citation statements)

References 54 publications

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“…The potential role of polyphenol-rich diets in the prevention of liver diseases has been reviewed previously; [ 58 ] however, data from clinical trials are limited. For example, the consumption of fresh mangoes for 12 weeks significantly reduced AST levels in overweight and obese adults, while no effects were observed for ALT and APh [ 59 ]. Similarly, citrus limonin glucoside supplementation (500 mg/day) for 127 days decreased concentrations of ALT and APh in overweight adults [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Dark Sweet Cherry (Prunus avium) Supplementation Reduced Blood Pressure and Pro-Inflammatory Interferon Gamma (IFNγ) in Obese Adults without Affecting Lipid Profile, Glucose Levels and Liver Enzymes

et al. 2023

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Dark sweet cherries (DSC) are rich in fiber and polyphenols that decrease risk factors associated with obesity. This single-blind randomized placebo-controlled study investigated DSC effects on inflammation, cardiometabolic, and liver health biomarkers in obese adults. Participants (>18 years, body mass index (BMI) = 30–40 kg/m2) consumed 200 mL of DSC drink (juice supplemented with DSC powder) (n = 19) or a placebo drink (n = 21) twice/day for 30 days. Anthropometric and physiological biomarkers were monitored at baseline (D1), mid-point (D15), and endpoint (D30) visits. Blood inflammatory biomarkers were assessed at D1, D15, and D30, and blood lipids, glucose, and liver enzymes at D1 and D30. DSC consumption lowered systolic blood pressure (SBP) (p = 0.05) and decreased diastolic blood pressure (DBP) compared to placebo (p = 0.04). Stratification of participants by BMI revealed a greater (p = 0.008) SBP reduction in BMI > 35 participants. DSC lowered pro-inflammatory interferon-gamma (IFNγ) (p = 0.001), which correlated with SBP changes. The interleukin (IL)-1RA and SBP changes were correlated in the placebo group, as well as triglycerides (TG) with DBP. The increased IL-10 levels in the placebo group suggested a compensatory mechanism to counteract elevated IFNγ levels. No significant between-group differences were detected for blood lipids, glucose, and liver enzymes. In conclusion, DSC helped to decrease blood pressure levels and inflammation in obese adults.

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Section: Discussionmentioning

confidence: 99%

Dark Sweet Cherry (Prunus avium) Supplementation Reduced Blood Pressure and Pro-Inflammatory Interferon Gamma (IFNγ) in Obese Adults without Affecting Lipid Profile, Glucose Levels and Liver Enzymes

et al. 2023

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“…Participants were recruited using posted flyers in local public places. Details on participant information have been previously explained by Rosas et al ( 2022 ). Briefly, there was a total of 27 participants (16 males and 11 females) with a mean age of 26.0 ± 8.1 years and a mean height of 172.4 ± 8.4 cm.…”

Section: Methodsmentioning

confidence: 99%

“…Mangos are rich in vitamins C and A, magnesium, potassium, bioactive phytochemicals (e.g., mangiferin, flavonoids, phenolic acids, and carotenoids), and fiber (Maldonado‐Celis et al, 2019 ; Ribeiro & Schieber, 2010 ). Mangos have been observed to promote many health benefits linked to inflammation and obesity, such as the reduction in pro‐inflammatory cytokines and C‐reactive protein (Fang et al, 2018 ; Rosas et al, 2022 ) and suppressing appetite while increasing satiety (Pinneo et al, 2022 ). The rich fiber content of mango may also exert a positive influence on the microbiome.…”

Section: Introductionmentioning

confidence: 99%

The effects of fresh mango consumption on gut health and microbiome – Randomized controlled trial

Asuncion

Liu

Castro

et al. 2023

Food Science & Nutrition

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Some individual fruits have been widely researched for their effects on overall health and correlations with chronic diseases. The beneficial effects of mango supplementation on metabolic diseases have been detected. However, research into mango consumption on gut health, including the microbiome, is limited to processed mango preparations or peels. Our goal was to examine the effects of fresh mango consumption on the gut microbiome, gut permeability proteins, and bowel movement habits in overweight/obese individuals. In a 12‐week crossover design study, 27 participants consumed 100 kcal/day of either mangos or low‐fat cookies with a washout period of 4 weeks. The mango intervention showed higher Shannon–Wiener and Simpson alpha diversity indices of the microbiome than the low‐fat cookie intervention in week 4. Significant differences in beta diversity of the microbiome were found between diet interventions at week 12. Mango consumption increased the abundance of Prevotella maculosa, Corynebacterium pyruviciproducens, and Mogibacterium timidum while it decreased Prevotella copri. Low‐fat cookie intake increased Cyanobacterium aponinum and Desulfovibrio butyratiphilus and reduced Alloscardovia omnicolens. There were no significant differences in circulating gut permeability protein (ZO‐1, claudin‐2, and occludin) levels. There was a slight increase in the amount of bowel movement with mango consumption, but no significant findings for frequency, consistency, strain, pain, and constipation in bowel movement between trials. Given these results, it can be concluded that consumption of mango may have positive effects on the gut health, which may yield possible health benefits for chronic disease that deserve further study.

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“…Mangoes are high in carotenoids (26 mg/100 g), polyphenols (145 mg/100 g), carbohydrates (15 g/100 g), vitamin C (36 mg/100 g), vitamin A (54 µg RAE/100 g), and folate (43 µg/100 g) [ 32 , 33 ]. The total antioxidant content of mangoes is high, and this popular fruit has been extensively investigated for its health-related effects [ 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. There are many types of polyphenols in mangoes, with a predominance of 3,4,5-trihydroxybenzoic acids (gallic acid) and other galloyl derivatives [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of 2 Weeks of Mango Ingestion on Inflammation Resolution after Vigorous Exercise

Sakaguchi,

Nieman,

Omar

et al. 2023

Nutrients

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Mangoes have a unique nutrient profile (carotenoids, polyphenols, sugars, and vitamins) that we hypothesized would mitigate post-exercise inflammation. This study examined the effects of mango ingestion on moderating exercise-induced inflammation in a randomized crossover trial with 22 cyclists. In random order with trials separated by a 2-week washout period, the cyclists ingested 330 g mango/day with 0.5 L water or 0.5 L of water alone for 2 weeks, followed by a 2.25 h cycling bout challenge. Blood and urine samples were collected pre- and post-2 weeks of supplementation, with additional blood samples collected immediately post-exercise and 1.5-h, 3-h, and 24 h post-exercise. Urine samples were analyzed for targeted mango-related metabolites. The blood samples were analyzed for 67 oxylipins, which are upstream regulators of inflammation and other physiological processes. After 2 weeks of mango ingestion, three targeted urine mango-related phenolic metabolites were significantly elevated compared to water alone (interaction effects, p ≤ 0.003). Significant post-exercise increases were measured for 49 oxylipins, but various subgroup analyses showed no differences in the pattern of change between trials (all interaction effects, p > 0.150). The 2.25 h cycling bouts induced significant inflammation, but no countermeasure effect was found after 2 weeks of mango ingestion despite the elevation of mango gut-derived phenolic metabolites.

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Effects of fresh mango consumption on cardiometabolic risk factors in overweight and obese adults

Cited by 10 publications

References 54 publications

Dark Sweet Cherry (Prunus avium) Supplementation Reduced Blood Pressure and Pro-Inflammatory Interferon Gamma (IFNγ) in Obese Adults without Affecting Lipid Profile, Glucose Levels and Liver Enzymes

Dark Sweet Cherry (Prunus avium) Supplementation Reduced Blood Pressure and Pro-Inflammatory Interferon Gamma (IFNγ) in Obese Adults without Affecting Lipid Profile, Glucose Levels and Liver Enzymes

The effects of fresh mango consumption on gut health and microbiome – Randomized controlled trial

Influence of 2 Weeks of Mango Ingestion on Inflammation Resolution after Vigorous Exercise

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