Effects of Fructooligosaccharides on Intestinal Flora and Human Health

Hidaka, Hiroyoshi; Eida, Toshiaki; Takizawa, Toshio; Tokunaga, Takahisa; Tashiro, Yasuhito

doi:10.12938/bifidus1982.5.1_37

Cited by 523 publications

(299 citation statements)

References 11 publications

Supporting

Mentioning

261

Contrasting

Unclassified

Order By: Relevance

“…Investigation of the intestinal microflora was performed as described previously (5) . Fecal SCFA and putrefactive substances were measured by gas chromatography.…”

Section: Methodsmentioning

confidence: 99%

Proliferation of Bifidobacteria by Oligosaccharides and Their Useful Effect on Human Health

Hidaka

Tashiro

Eida

1991

Bifidobacteria Microflora

Self Cite

137

View full text Add to dashboard Cite

Studies of oligosaccharides have recently become common, especially in Japan. This has been because of findings of marked biofunctions and usefulness of fructooligosaccharides (FOS) for human health due to their effect of improving the intestinal microflora. In this paper, we demonstrate several useful characteristics of FOS such as cholesterol reduction, suppression of putrefaction, normalization of microbial disorders of the colon and alleviation of constipation in clinical studies. It seems that the usefulness of FOS is related to the proliferation of bifidobacteria and other saccharolytic intestinal bacteria and also short chain fatty acids produced by these organisms .

show abstract

“…Investigation of the intestinal microflora was performed as described previously (5) . Fecal SCFA and putrefactive substances were measured by gas chromatography.…”

Section: Methodsmentioning

confidence: 99%

Proliferation of Bifidobacteria by Oligosaccharides and Their Useful Effect on Human Health

Hidaka

Tashiro

Eida

1991

Bifidobacteria Microflora

Self Cite

137

View full text Add to dashboard Cite

show abstract

“…There are currently no tables of oligosaccharide content of foods and few data giving oligosaccharide consumption in any populations in the world (Loo et al, 1995). The most important physiological property of NDO currently known, is to stimulate selectively the growth of bi®dobacteria in the colon and possibly thereby increase colonisation resistance to pathogenic organisms Hidaka et al, 1986). In this context they are known as prebiotics (Gibson & Roberfroid, 1995).…”

Section: Mixture Syntheticmentioning

confidence: 99%

“…Some starches affect large bowl function (Cummings et al, 1996;Munster et al, 1994;Phillips et al, 1995) and the concept of resistant starch (RS) has been developed (Englyst et al, 1992). Recently the importance of a previously neglected group of carbohydrates, the oligosaccharides, has emerged with the demonstration that some are fermented in the colon and selectively stimulate the growth of speci®c intestinal bacteria thought to be bene®cial to health Gibson & Roberfroid, 1995;Hidaka et al, 1986). This knowledge requires a new framework for classifying and measuring dietary carbohydrate and is necessary for food labelling and public health policy.…”

Section: Introductionmentioning

confidence: 99%

A new look at dietary carbohydrate: chemistry, physiology and health

Jh¹,

Roberfroid²,

Andersson³

et al. 1997

Eur J Clin Nutr

160

View full text Add to dashboard Cite

The current view of dietary carbohydrates as simply providing us with energy is outdated. Because of their varied chemistry and physical form the rate and extent to which the different types are digested in and absorbed from the small intestine varies. This in turn leads to affects on satiety, blood glucose and insulin, protein glycosylation, lipids and bile acids. Some carbohydrates reach the colon where they are fermented and affect many aspects of large bowel function, colonocyte and hepatic metabolism.A new framework for classifying and measuring food carbohydrates is needed to allow a greater understanding of the role of individual species in health and to inform the public of their importance. A classi®cation based primarily on molecular size (degree of polymerisation) into sugars, oligosaccharides and polysaccharides, is suggested, with sub-groups identi®ed by the nature of the monosaccharides. Greater knowledge of the chemical and physical properties of carbohydrates allow a more precise relation with physiology and health to be drawn.The Carbohydrate Group met in Paris in December 1995 at the invitation of Gerard Pascal, Director of CNERNA. Financial support for the meeting was provided by CNERNA.

show abstract

“…FOS are not hydrolyzed by endogenous enzymes in the small intestine of humans and following ingestion reach the cecum and colon in intact form, where they are metabolized completely by the colonic microflora, through fermentation, producing gases (carbon dioxide, hydrogen, methane) and reducing the colon pH by lactate and SCFA production, such as acetate, propionate and butyrate, which are quickly absorbed by the colonic mucosa [13][14][15][16][17] .…”

Section: Metabolism Of Fosmentioning

confidence: 99%

Fructo-oligosaccharide effects on blood glucose: an overview

2012

View full text Add to dashboard Cite

PURPOSE:To identify the current status of scientific knowledge in fructo-oligosaccharides (FOS), non-conventional sugars that play an important role in glycemia control. METHODS:We performed a search for scientific articles in MEDLINE and LILACS databases, from January 1962 to December 2011, using English/Portuguese key words: "blood glucose/glicemia", "prebiotics/prebióticos" and "dietary fiber/fibras na dieta". From an initial number of 434 references, some repeated, 43 references published from 1962 to 2011 were included in this study. The selected texts were distributed in three topics: (1) metabolism of FOS, (2) FOS and experimental studies involving glucose and (3) human studies involving glucose and FOS. RESULTS:Five studies have shown that the use of FOS reduces the fecal content and increases intestinal transit time. Experimental studies have shown that dietary supplementation with high doses (60 g/Kg) of propionate, a short-chain fatty acid decreased glycemia.The use of lower doses (3 g/kg) did not produce the same results. Study in subjects with diabetes type II showed that the addition of 8 grams of FOS in the diet for 14 days, caused a reduction in serum glucose. In another study with healthy subjects, there were no changes in glycemic control. CONCLUSIONS:This review demonstrates that consumption of FOS has a beneficial influence on glucose metabolism. The controversies appear to be due to inadequate methodological designs and/or the small number of individuals included in some studies.Key words: Review. Blood Glucose. Oligosaccharides. Prebiotics. Dietary Fiber. RESUMO OBJETIVO:Conhecer o estado atual do conhecimento científico em fructooligossacarídeos (FOS), açúcares não-convencionais que desempenham um papel importante no controle da glicemia. MÉTODOS: Realizamos uma busca de artigos científicos nas bases de dados MEDLINE e Literatura Latino-Americana e do Caribe emCiências da Saúde (LILACS), a partir de janeiro 1962 a dezembro de 2011, usando como descritores termos Português/Inglês: "glicemia/ blood glucose, "prebióticos/prebiotics" e "fibras na dieta/dietary fiber. A partir de um número inicial de 434 referências, algumas repetidas, 43 referências foram consideradas adequadas para a finalidade deste estudo e foram, portanto, selecionadas para análise. Os textos selecionados foram distribuídos em três tópicos: (1) metabolismo de FOS (2), FOS e estudos experimentais envolvendo glicose e (3) estudos em humanos envolvendo glicose e FOS. RESULTADOS: Cinco trabalhos mostraram que o uso de FOS diminui o conteúdo fecal e aumenta o tempo do transito intestinal.Estudos experimentais demonstraram que a suplementação dietética com altas doses (60 g/Kg) de propionato, um ácido graxo de cadeia curta, diminuiu a glicemia. A utilização de doses menores (3 g/Kg) não produziu os mesmos resultados. Em indivíduos diabéticos tipo II a adição de 8 g de FOS na dieta, durante 14 dias, induziu uma redução da glicemia. Em indivíduos sadios, não ocorreram alterações da glicemia. CONCLUSÕES:Essa revisão mostra...

show abstract

Effects of Fructooligosaccharides on Intestinal Flora and Human Health

Cited by 523 publications

References 11 publications

Proliferation of Bifidobacteria by Oligosaccharides and Their Useful Effect on Human Health

Proliferation of Bifidobacteria by Oligosaccharides and Their Useful Effect on Human Health

A new look at dietary carbohydrate: chemistry, physiology and health

Fructo-oligosaccharide effects on blood glucose: an overview

Contact Info

Product

Resources

About