Effects of Fructus Piperis Longi extract on fibrotic liver of gamma-irradiated rats

Mansour, Somaya Z; El-kabany, Hanan Ahmed

doi:10.1186/1749-8546-4-2

Cited by 10 publications

(5 citation statements)

References 42 publications

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“…These findings are consistent with previous investigations which indicated that TAA caused a significant decrease in the levels of liver SOD and GSH [12, 55, 56]. TAA is a well-known liver hepatotoxicant, the hepatotoxicity results from its metabolic conversion to free radical products: thioacetamide sulfoxide and thioacetamide-S, S-dioxide which attacks microsomal lipids leading to their peroxidation and production of reactive oxygen species (ROS), such as the H 2 O 2 , super oxide anion O 2 − , and the hydroxyl radical.…”

Section: Discussionsupporting

confidence: 94%

Attenuating Effect ofGinkgo bilobaLeaves Extract on Liver Fibrosis Induced by Thioacetamide in Mice

Al-Attar

2012

Journal of Biomedicine and Biotechnology

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The purpose of this study is to investigate the effect of Ginkgo biloba leaves extract on experimental liver fibrosis induced by thioacetamide (TAA) in male albino mice. The experimental mice were divided into four groups. The mice of the first group were served as control. The experimental animals of the second group were given 150 mg/kg body weight of TAA by intraperitoneal injection, twice weekly, for 9 weeks. The mice of the third group were exposed to TAA and supplemented with G. biloba leaves extract. The animals of the fourth group were supplemented with G. biloba leaves extract. The levels of plasma alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, triglycerides, cholesterol, and low-density lipoprotein cholesterol were statistically increased while the levels of plasma total protein, albumin, glucose, and high-density lipoprotein cholesterol were significantly decreased. The levels of liver superoxide dismutase, glutathione, glycogen and total protein were notably declined, whereas the level of total lipid was increased in mice of the second group. Furthermore, microscopic examination of liver sections from mice treated with TAA showed an abnormal morphology characterized by nodular transformations in liver parenchyma which surrounded by fibrous septa. Administration of G. biloba leaves extract reduced extent and development of fibrous septa, liver cells change, and biochemical alterations in mice exposed to TAA. This study showed that G. biloba leaves extract has a potential activity against TAA-induced liver fibrosis and suggested that the chemical constituents of G. biloba are effective in modulation of oxidative stress induced by TAA.

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Section: Discussionsupporting

confidence: 94%

Attenuating Effect ofGinkgo bilobaLeaves Extract on Liver Fibrosis Induced by Thioacetamide in Mice

Al-Attar

2012

Journal of Biomedicine and Biotechnology

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“…The obtained data revealed significant increase in AST, ALT and GGT activities in irradiated rats throughout the experimental period. The observed increase in the hepatotoxicity biomarkers agree with the previous studies (Ashry and Hussein, 2007;Mansour and El-Kabany, 2009). The increase in the level of liver enzymes might be a result of the damage in hepatic cellular membranes (Gaur and Bhatia, 2009), impair of intrahepatic and extrahepatic bile flow, injury of hepatobiliary, or destruction of erythrocyte induced by irradiation (Singh et al, 2011).…”

Section: Discussionsupporting

confidence: 92%

Efficiency of Borage Seeds Oil Against Gamma Irradiation-Induced Hepatotoxicity in Male Rats: Possible Antioxidant Activity

Khattab¹,

Abdallah²,

Yousef³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Borage (Borago officinal L.) is an annual herbaceous plant of great interest because its oil contains a high percentage of -linolenic acid (GLA). The present work was carried out to detect fatty acids composition of the oil extracted from borage seeds (BO) and its potential effectiveness against γ-irradiation-induced hepatotoxicity in male rats. Materials and Methods: GC-MS analysis of fatty acids methyl esters of BO was performed to identify fatty acids composition. Sixty rats were divided into five groups (12 rats each): Control, irradiated; rats were exposed to (6.5 Gy) of whole body γ-radiation, BO (50 mg/kg b.wt), irradiated BO post-treated and irradiated BO prepost-treated. Six rats from each group were sacrificed at two time intervals 7 and 15 days post-irradiation. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT) levels, lipids profile, as well as serum and hepatic reduced glutathione (GSH) and lipid peroxide (malondialdehyde) (MDA) levels were assessed. Histopathological examination of liver sections were also carried out. Results:The results showed that the high contents of BO extracted by cold pressing, were linoleic acid (34.23%) and GLA (24.79%). Also, oral administration of BO significantly improved serum levels of liver enzymes, lipids profile, as well as serum and hepatic GSH and MDA levels (p<0.001) as compared with irradiated rats after 15 days post irradiation. Moreover, it exerted marked amelioration against irradiation-induced histopathological changes in liver tissues. The improvement was more pronounced in irradiated BO prepost-treated group than irradiated BO post-treated. Conclusion: BO has a beneficial role in reducing hepatotoxicity and oxidative stress induced by radiation exposure. Therefore, BO may be used as a beneficial supplement for patients during radiotherapy treatment.

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“…Alternatively, antioxidative activity of the KSOP1009 could be responsible for its neuroprotective effects against cytotoxicity of A␤42. Several studies have reported the antioxidant effects of the herbs that comprise KSOP1009 (Yokozawa et al, 1995;Park et al, 2006;Chaieb et al, 2007;Jeong et al, 2009;Mansour and El-Kabany, 2009). Given that oxidative stress has been implicated in AD (Emerit et al, 2004) and induced cell death via JNK activation (Shen and Liu, 2006), the antioxidative activity of the KSOP1009 may inhibit hyperactivation of JNK, thereby protecting cells from apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of SuHeXiang Wan in Drosophila models of Alzheimer's disease

Hong

Park

Lee

et al. 2011

Journal of Ethnopharmacology

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Effects of Fructus Piperis Longi extract on fibrotic liver of gamma-irradiated rats

Cited by 10 publications

References 42 publications

Attenuating Effect ofGinkgo bilobaLeaves Extract on Liver Fibrosis Induced by Thioacetamide in Mice

Attenuating Effect ofGinkgo bilobaLeaves Extract on Liver Fibrosis Induced by Thioacetamide in Mice

Efficiency of Borage Seeds Oil Against Gamma Irradiation-Induced Hepatotoxicity in Male Rats: Possible Antioxidant Activity

Neuroprotective effect of SuHeXiang Wan in Drosophila models of Alzheimer's disease

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