Effects of GABA antagonists on inhibitory avoidance

Cruz-Morales, Sara E.; Quírarte, Gina L.; Guante, Miguel A. Diaz Del; Prado-Alcalá, Roberto A.

doi:10.1016/0024-3205(93)90578-q

Cited by 13 publications

(9 citation statements)

References 15 publications

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“…Despite the facts that the involvement of GABA in memory has received experimental support and GABAergic drugs have definite effects on memory replicated in numerous studies of different laboratories, there is a large number of marked inconsistencies in the reported results (see Table 3, and data on picrotoxin and bicuculline in Cruz-Morales et al, 1993). In line with this, for example, discussing amnestic effects of BDZ, File et al (1992) and Curran (1994) ask the important questions: How specific such effects are to memory functions?…”

Section: Inconsistencies and Cautionscontrasting

confidence: 49%

“…However, the GABA-A agonist muscimol administered to entorhinal cortex was reported to induce amnesia (Rosat et al, 1992) or block memory of habituation and inhibitory avoidance in animals . As predicted, opposite to agonists, GABA antagonists like bicuculline were found to be strong memory-activating agents (Cruz-Morales et al, 1993). Indirect GABA modulators such as BDZ agonists have also been studied (see review in Lister, 1990).…”

Section: Neuropharmacology Of Gabaergic Drugs Affecting Memoriesmentioning

confidence: 97%

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Role of GABA in memory and anxiety

1996

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This review assesses the parallel literature on the role of gamma‐aminobutyric acid (GABA) in memory and anxiety. We review historical and new data from both animal and human experimentation which have helped define the key role for this transmitter in both these mental states. By exploring the overlap in these conditions in terms of pharmacology, brain circuitry, and clinical phenomenology, we begin to develop a theory that the two conditions are intrinsically interrelated. The role of GABAergic agents in dissecting out and demonstrating this interrelationship and in pointing the way to future research is discussed. Depression and Anxiety 4:100–110, 1996/1997.© 1997 Wiley‐Liss, Inc.

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Section: Inconsistencies and Cautionscontrasting

confidence: 49%

Section: Neuropharmacology Of Gabaergic Drugs Affecting Memoriesmentioning

confidence: 97%

Role of GABA in memory and anxiety

1996

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“…These contradictory effects could be explained by the different procedures adopted for the training sessions. To test for this possibility, rats were trained in a passive avoidance paradigm using two levels of footshock and injected with a wide range of doses of picrotoxin and bicuculline (Cruz-Morales et al 1993). It was concluded that GABA is involved in memory consolidation, and that the conflicting results in the literature may indeed be due, in part, to procedural differences.…”

Section: Discussionmentioning

confidence: 98%

The modulatory effects of high affinity GABA B receptor antagonists in an active avoidance learning paradigm in rats

Getova

Bowery²

1998

Psychopharmacology

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It has been reported that selective GABA(B) receptor antagonists can enhance cognitive performance in a variety of learning paradigms. This prompted us to examine the effects of some more potent and newly synthesised GABAB antagonists CGP 71982, CGP 62349 and CGP 55845A in an active avoidance test in rats. A two-way active avoidance test with negative reinforcement was performed for the first 5 of 12 days of antagonist administration. CGP 71982 and CGP 55845A at all doses applied (0.01-1.0 mg/kg) had an improving effect on learning, and memory retention on day 12; the rats made more avoidances in both sessions compared to controls. CGP 62349 was only active at the lowest dose tested (0.01 mg/kg). The present study confirms that GABA(B) receptor antagonists can enhance cognitive performance but provides no insight into the mechanism of action of these novel antagonists.

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“…Drugs which modulate the GABAergic system at different stages like GABA synthesis, GABA binding site, or chloride channels significantly affect memory and cognitive ability (Cruz-Morales et al 1993). Similarly, GABA antagonist and some GABA inhibiting steroids like pregenolone-sulfate show significant improvement in learning and memory (Flood et al 1992).…”

Section: Page 12 Of 32mentioning

confidence: 99%

Quantitative-profiling of neurotransmitter abnormalities in the disease progression of experimental diabetic encephalopathy rat

Zhou

Zhu

Han

et al. 2015

Can. J. Physiol. Pharmacol.

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Diabetic encephalopathy (DE) is one of the most prevalent chronic complications of diabetes mellitus (DM), with neither effective prevention nor proven therapeutic regimen. This study aims to uncover the potential dysregulation pattern of the neurotransmitters in a rat model of streptozotocin (STZ)-induced experimental DE. For that purpose, male Sprague-Dawley (SD) rats were treated with a single intraperitoneal injection of STZ. Cognitive performance was detected with the Morris water maze (MWM) test. Serum, cerebrospinal fluid (CSF), and brain tissues were collected to measure the levels of neurotransmitters. Compared with the control rats, the acetylcholine (ACh) levels in serum, CSF, hippocampus, and cortex were all significantly down-regulated as early as 6 weeks in the STZ treatment group. In contrast, the glutamate (Glu) levels were decreased in CSF and the hippocampus, but unaffected in the serum and cortex of STZ-treated rats. As for γ-aminobutyric acid (GABA), it was down-regulated in serum, but up-regulated in CSF, hippocampus, and the cortex in the STZ-treated group. The mRNA expressions of neurotransmitter-related rate limiting enzymes (including AChE, GAD1, and GAD2) and pro-inflammatory cytokines (including IL-1β and TNF-α) were all increased in the DE rats. Our data suggest that DM induces isoform-dependent and tissue-specific neurotransmitter abnormalities, and that neuroinflammation may underlay the nervous system dysfunction observed in the progression of DE.

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Effects of GABA antagonists on inhibitory avoidance

Cited by 13 publications

References 15 publications

Role of GABA in memory and anxiety

Role of GABA in memory and anxiety

The modulatory effects of high affinity GABA B receptor antagonists in an active avoidance learning paradigm in rats

Quantitative-profiling of neurotransmitter abnormalities in the disease progression of experimental diabetic encephalopathy rat

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