Effects of gallic acid on delta – aminolevulinic dehydratase activity and in the biochemical, histological and oxidative stress parameters in the liver and kidney of diabetic rats

Oliveira, Lizielle Souza de; Thomé, Gustavo R.; Lopes, Thauan Faccin; Reichert, Karine Paula; Oliveira, Juliana Sorraila de; Pereira, Aline da Silva; Baldissareli, Jucimara; Krewer, Cristina da Costa; Morsch, Vera Maria; Schetinger, Maria Rosa Chitolina; Spanevello, Rosélia Maria

doi:10.1016/j.biopha.2016.10.021

Cited by 37 publications

(22 citation statements)

References 39 publications

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“…This indicates that the consumption of fruit purees had a significant effect in decreasing ALT activity, probably due to the content of bioactive compounds in the diets. Several reports have demonstrated that polyphenols increased the expression of genes that contribute to the hepatoprotective effect, if the liver is regenerated, the ALT activity decreases (de Oliveira et al, 2016). It is probable that the consumption of fruit purees improves the inflammatory systemic conditions, and for this reason a decrease in the ALT activity was observed.…”

Section: Resultsmentioning

confidence: 98%

Effect of Low-Fat Diets Enriched with Fruit Purees on the Biochemical Markers of Metabolic Syndrome Analogy Induced-Rats

et al. 2020

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Fruit purees can be added to diet as alternative sources of bioactive compounds for the prevention and/or improvement of the complications of metabolic syndrome. In this work we evaluated the effect of the intake of low-fat diets enriched with fruit purees (guava-strawberry, guava-blackberry, guava-soursop, guava-passion fruit) on the body weight and biochemical markers in metabolic syndrome analogy (MSA)-induced rats. The rats (n=6 for each treatment) were induced with a high fat diet and were injected with streptozotocin, one dose every week for 4 consecutive weeks after fasting overnight, then healthy rats were fed with standard diet and MS rats were fed with standard diet plus each of the fruit puree, for 4 weeks. As novel findings, the diet enriched with fruit purees was associated with a reduction in body weight (~13-21 %) and a control in the metabolism of glucose by decreasing plasma glucose (~59-63 %). Also, there was a reduction in the total cholesterol, triacylglycerols, low-density lipoproteins, and low enzymatic activities of alanine aminotransferase, alkaline phosphatase and γ-glutamyl transferase, useful metabolites in the control of inflammatory processes in the liver. A notable improvement in the liver morphology was observed indicating that the treatments had a hepatoprotective effect. The diet enriched with guava-blackberry puree caused the best results on most biochemical markers of MS rats. Therefore, diets enriched with fruit purees can be an alternative for MS individuals for the control and improvement of the complications caused by this syndrome.

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Section: Resultsmentioning

confidence: 98%

Effect of Low-Fat Diets Enriched with Fruit Purees on the Biochemical Markers of Metabolic Syndrome Analogy Induced-Rats

et al. 2020

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“…Several biological properties are associated with gallic acid, such as antioxidant and anti-inflammatory activity, anti-carcinogenic activity, and antihyperglycemic effects such as lowering glucose and glycosylated hemoglobin levels and increasing insulin levels in experimental diabetes models. This suggests the possibility of using gallic acid as a complementary therapy to hypoglycemic drugs (Oliveira et al, 2016;Pereira et al, 2018. ).…”

Section: Resultsmentioning

confidence: 99%

In vitro bioaccessibility and identification of antioxidant compounds in clarified cashew apple juice ‘cajuína’

Porto-Luz

Soares

Silva

et al. 2020

BJD

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“…Caffeic acid can effectively reduce the weight loss of diabetic rats, increase plasma insulin, lower plasma glucose levels and heart tissue and plasma triglycerides (Chao and others ). Gallic acid could prevent a decrease in the activity of catalase and glutathione S‐transferase, and vitamin C levels in the liver of diabetic rats, and then can protect against oxidative stress‐induced damage in the diabetic state (de Oliveira and others ). So the biological activity of polyphenols may be due to the combined effect of these polyphenol compounds and others, thus prevent free radical mediated diseases.…”

Section: Resultsmentioning

confidence: 99%

Antidiabetic and Lipid‐Lowering Effects of the Polyphenol Extracts from the Leaves of Clausena lansium (Lour.) Skeels on Streptozotocin‐Induced Type 2 Diabetic Rats

Kong

Guo

et al. 2017

Journal of Food Science

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Clausena lansium (Lour.) Skeels (Wampee) is widely grown in China and considered as a healthy fruit. Its leaves are also considered as traditional herbs. This study analyzed polyphenol compounds in polyphenol extracts of the leaves C. lansium (lour.) Skeels (PEL) and investigated the protective effect of PEL against hyperglycemia and hyperlipidemia in T2DM rats. The result showed that PEL is composed mainly of gallic acid, chlorogenic acid, coffee acid, ferulic acid, and rutin. PEL could obviously relieve some symptoms of T2DM rats, including emaciation, hyperhidrosis, polyphagia, diuresis, liver swelling, kidney, and pancreas hypertrophy, as well as reduce fasting blood glucose. Moreover, the supplementation of PEL significantly ameliorated lipids disorder and protected liver in T2DM rats, including fat accumulation, improvement of lipid distribution and hepatocyte protection. These results indicate that the Oral of PEL have potential effects of against hyperglycemia and hyperlipidemia in diabetic disorders.Keywords: antidiabetic, lipid-lowering, liver protection, polyphenolPractical Application: The leaves Clausena lansium (lour.) Skeels is rich in polyphenol and other ingredients. In this research, the preliminary study shows that PEL can reduce fasting blood glucose and improve lipids disorder in rats, which will bring to diabetic patients a way to improve the disease and enhance the quality of life. The PEL therefore can be used for the production of pharmaceutical raw materials and the design of novel functional foods by simple conversion.

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Effects of gallic acid on delta – aminolevulinic dehydratase activity and in the biochemical, histological and oxidative stress parameters in the liver and kidney of diabetic rats

Cited by 37 publications

References 39 publications

Effect of Low-Fat Diets Enriched with Fruit Purees on the Biochemical Markers of Metabolic Syndrome Analogy Induced-Rats

Effect of Low-Fat Diets Enriched with Fruit Purees on the Biochemical Markers of Metabolic Syndrome Analogy Induced-Rats

In vitro bioaccessibility and identification of antioxidant compounds in clarified cashew apple juice ‘cajuína’

Antidiabetic and Lipid‐Lowering Effects of the Polyphenol Extracts from the Leaves of Clausena lansium (Lour.) Skeels on Streptozotocin‐Induced Type 2 Diabetic Rats

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