Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects

Hayamizu, Kohsuke; Tomi, Hironori; Kaneko, Izuru; Shen, Manzhen; Soni, Madhu G.; Yoshino, Gen

doi:10.1016/j.fitote.2007.12.003

Cited by 23 publications

(17 citation statements)

References 19 publications

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“…(-)-HCA-containing products have been on the market for many years [18, 27]. A number of reports demonstrated the efficacy of extracts from Garcinia cambogia or (-)-HCA were found in animals [18, 52-54] and humans [55-57]. The liver is the primary site of metabolism in poultry [35].…”

Section: Discussionmentioning

confidence: 99%

(-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes

Li¹,

Peng²,

Ge³

et al. 2017

Cell Physiol Biochem

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Background/Aims: (-)-Hydroxycitric acid (HCA) had been shown to suppress fat accumulation in animals and humans, while the underlying biochemical mechanism is not fully understood, especially little information is available on whether (-)-HCA regulates energy metabolism and consequently affects fat deposition. Methods: Hepatocytes were cultured for 24 h and then exposed to (-)-HCA (0, 1, 10, 50 µM), enzyme protein content was determined by ELISA; lipid metabolism gene mRNA levels were detected by RT-PCR. Results: (-)-HCA significantly decreased the number and total area of lipid droplets. ATP-citrate lyase, fatty acid synthase and sterol regulatory element binding protein-1c mRNA level were significantly decreased after (-)-HCA treatment, whereas peroxisome proliferator-activated receptor α mRNA level was significantly increased. (-)-HCA significantly decreased ATP-citrate lyase activity and acetyl-CoA content in cytosol, but significantly increased glucose consumption and mitochondrial oxygen consumption rate. (-)-HCA promoted the activity/content of glucokinase, phosphofructokinase-1, pyruvate kinase, pyruvate dehydrogenase, citrate synthase, aconitase, succinate dehydrogenase, malate dehydrogenase, NADH dehydrogenase and ATP synthase remarkably. Conclusions: (-)-HCA decreased lipid droplets accumulation by reducing acetyl-CoA supply, which mainly achieved via inhibition of ATP-citrate lyase, and accelerating energy metabolism in chicken hepatocytes. These results proposed a biochemical mechanism of fat reduction by (-)-HCA in broiler chickens in term of energy metabolism.

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Section: Discussionmentioning

confidence: 99%

(-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes

Li¹,

Peng²,

Ge³

et al. 2017

Cell Physiol Biochem

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“…The histological preparations of the testis and epididymis revealed toxic effects that were more pronounced in the group receiving 200 mg/kg body weight of extract, thereby indicating a dose-dependent toxic effect. However, G. cambogia extract administration to overweight human subjects for 12 weeks neither significantly altered serum testosterone, estrone, or estradiol levels nor induced any adverse effects with respect to hematology and serum clinical pathology parameters (Hayamizu et al, 2008). The seeds of another plant of Garcinia genus, Garcinia kola, have been reported to increase the peripheral testosterone level (Akpantah et al, 2003), which may have increased the sperm counts as observed in rabbits after feeding 35 mg/kg of G. kola (Akinloye et al, 1999).…”

Section: Toxicitymentioning

confidence: 82%

“…Hayamizu et al (2008), in a trial involving humans provided 1,000 mg HCA per day (i.e., 1,666 mg of 60 % and HCA salt) for 3 months, observed no significant changes in hepatic function parameters. None of the human trials has documented any significant adverse effects on the liver.…”

Section: Toxicitymentioning

confidence: 94%

Garcinia cambogia

Raina¹,

Mondhe²,

Malik³

et al. 2016

Nutraceuticals

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“…High dose of HCA‐containing G. cambogia (102 mmol HCA per kilogram diet and higher) caused potent testicular atrophy and toxicity in rats (54). Administration of G. cambodia extract at recommended dose levels for human use does not show any significant adverse effect on serum testosterone and blood parameters (59). The studied extract dose was 1667.3 mg d −1 equivalent to 1000 mg HCA per day.…”

Section: Energy Intake Reductionmentioning

confidence: 96%

Comprehensive review on herbal medicine for energy intake suppression

Yuliana

Jahangir

Korthout³

et al. 2011

Obesity Reviews

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The obesity drug development is present not a bright and successful story. So far, drugs reported to be effective, either from synthetic or natural sources, mostly stimulated controversy because of serious adverse effects, which ended with stopping clinical trials or even withdrawal from the market. However, obesity and its comorbidities have become rapidly a major problem in both developed and developing countries. This has encouraged pharmaceutical companies and academia to keep on struggling on developing novel effective but safe obesity drugs, and on characterizing novel obesity drug targets. From existing scientific work on obesity drug discovery and commercial slimming preparations, compounds originating from nature, especially from plants, seem to be the first choice. Traditional belief that herbal medicine is safer than synthetic ones is one of the classical arguments, although scientifically this is not always true (e.g. ban on Ephedra). But in general, it has been widely acknowledged that a plant compound, with its unique scaffolds and rich diversity is an unlimited source of novel lead compounds. This paper aims to summarize all works focused on screening plant materials by targeting important pathways related to energy intake regulation, either by in vivo or in vitro experiments.

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Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects

Cited by 23 publications

References 19 publications

(-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes

(-)-Hydroxycitric Acid Reduced Lipid Droplets Accumulation Via Decreasing Acetyl-Coa Supply and Accelerating Energy Metabolism in Cultured Primary Chicken Hepatocytes

Garcinia cambogia

Comprehensive review on herbal medicine for energy intake suppression

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