Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol

Durak, İlker; Kavutçu, Mustafa; Aytaç, Bilal; Avcı, Aslıhan; Devrım, Erdinç; Özbek, Hanefí; Öztürk, Hasan Serdar

doi:10.1016/j.jnutbio.2004.01.005

Cited by 140 publications

(73 citation statements)

References 35 publications

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“…These results are in agreement with many studies [44,45] who found that dietary supplement of garlic extract activated the antioxidant system and decreased peroxidation in aortic tissue in their experimental model. The water-soluble organo-sulfur compounds of garlic including S-allyl cysteine, S-allylmercaptocyteine, allicin, and selenium exhibited potent antioxidant and free radical scavenging activities in vitro and in vivo [46,47].…”

Section: Discussionsupporting

confidence: 93%

Protictive effects of green tea and garlic on the morphological and oxidative stress changes of hippocampus in aged male and female albino rats

El‐Sokkary¹,

Alghriany²,

Atia³

2018

J Histol Histopathol

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Objective: Green tea is an extremely popular drink and particularly rich in strong antioxidants, flavonoids. Also, garlic is important dietary and has medicinal role for centuries and possess both antioxidant and antiinflammatory action in several oxidative stress conditions. Materials and methods: Four groups of both male and female rats [young (3 months-old), aged (26 months-old), aged+green tea (200 mg/kg) and aged+garlic (100 mg/kg)] were used. Histological changes in the pyramidal cells of the hippocampus were examined. Levels of oxidized lipids (LPO), superoxide dismutase (SOD) activity and glutathione concentration (GSH) were measured in the serum. Results: Irregular, shrinked and deeply stained large and small pyramidal cells with fragmented nuclei and basophilic cytoplasm observed in the hippocampus of aged male and female rats. Green tea and garlic administration preserve these changes in the pyramidal cells in both genders. Aging increased the level of LPO, decreased the activity of SOD and the concentration of GSH of both male and female rats versus those of young ones. Again, green tea and garlic ameliorated these changes. Conclusion: our results showed that the protective role of green tea and garlic against oxidative stress parameters was more effective in males than females. Morphologically, garlic exerted preservation to the pyramidal cells of hippocampus more than green tea in both genders. This study suggests that the use of both green tea and garlic may inhibit the bodily changes related to aging.

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Section: Discussionsupporting

confidence: 93%

Protictive effects of green tea and garlic on the morphological and oxidative stress changes of hippocampus in aged male and female albino rats

El‐Sokkary¹,

Alghriany²,

Atia³

2018

J Histol Histopathol

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“…In hypertensive patients, Durak et al 68 showed that garlic extract supplementation improves blood lipid profile, strengthens blood antioxidant potential and decreases the level of malondialdehyde in blood samples. In patients suffering from coronary artery disease, administration of garlic significantly reduced serum TC and TG, and increased HDL-C 69 .…”

Section: Discussionmentioning

confidence: 99%

Potential Protective Effects of Nigella Sativa and Allium Sativum Against Fructose-Induced Metabolic Syndrome in Rats

Al-Rasheed

Bassiouni

et al. 2014

J. Oleo Sci.

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“…It was reported that blood lipid was markedly decreased by intravenous injection combined with concomitant oral administration of Flos Lonicerae extract for cases of hyperlipidemia (Chang and But, 1986). We suspect that the activity of Flos Lonicerae extract may be linked with its antioxidant components, because antioxidants have been thought to be involved in reducing production of free radicals and arterial deposition of cholesterol as well as blood lipid (Chang and But, 1986;Chenni et al, 2007;Durak et al, 2004;Fernández-Checa, 2003;Joshi et al, 2001;Ramkumar et al, 2003;Yang et al, 2006;Zhang et al, 2001).…”

Section: Determination Of Antioxidant Activity Of Flos Lonicerae Extrmentioning

confidence: 95%

Effect of chlorogenic acid on antioxidant activity of Flos Lonicerae extracts

Lan

2007

J. Zhejiang Univ. - Sci. B

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Abstract:Flos Lonicerae is a medically useful traditional Chinese medicine herb. However, little is known about the antioxidant properties of Flos Lonicerae extracts. Here the antioxidant capacity of water, methanolic and ethanolic extracts prepared from Flos Lonicerae to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and reduce Fe 3+ to Fe 2+ is examined. Chlorogenic acid, a major component of Flos Lonicerae, is identified and further purified from 70% ethanolic extract with high performance liquid chromatography (HPLC) and its antioxidant capacity is characterized. The total phenolic compounds and chlorogenic acid contents in Flos Lonicerae are determined. The present results demonstrate that the Flos Lonicerae extracts exhibit antioxidant activity and chlorogenic acid is a major contributor to this activity.

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Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol

Cited by 140 publications

References 35 publications

Protictive effects of green tea and garlic on the morphological and oxidative stress changes of hippocampus in aged male and female albino rats

Protictive effects of green tea and garlic on the morphological and oxidative stress changes of hippocampus in aged male and female albino rats

Potential Protective Effects of Nigella Sativa and Allium Sativum Against Fructose-Induced Metabolic Syndrome in Rats

Effect of chlorogenic acid on antioxidant activity of Flos Lonicerae extracts

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