Effects of gastric electrical stimulation on hippocampus gastric distension responsive neurons and the expression of motilin and neuronal nitric oxide synthase in rats

Lu, Yong; Luo, Xu; Sun, Xiang Rong; Wei, Xiao; Jiang, Lu; Chen, Jian De

doi:10.11569/wcjd.v15.i13.1463

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“…While previous study proved that L-arginine (L-AA) can increase the excited function of gastric distension neurons in the hippocampus in rats (Lu et al, 2007), nitric oxide synthase (NOS) is newly found in the hippocampus (Lu et al, 2010b), leading to the question whether nitric oxide (NO) is involved in the regulatory effect of motilin on gastrointestinal motility. In order to determine the role of NO in motilinmediated effects on hippocampal neurons, the interaction between motilin and NO in the hippocampus using the whole-cell patch-clamp was investigated in the present study.…”

Section: Introductionmentioning

confidence: 99%