Effects of gender and gonadectomy on responses to chronic benzodiazepine receptor agonist exposure in rats

Wilson, Marlene A.; Biscardi, Rosemary

doi:10.1016/0014-2999(92)90614-a

Cited by 33 publications

(12 citation statements)

References 34 publications

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“…BZ treatment used 60-mm long silastic capsules that were either empty (vehicles) or filled with 90 mg crystalline DZ (a gift from F.Hoffman-LaRoche Ltd., Basel, Switzerland) and implanted subcutaneously under brief halothane anesthesia. To achieve equivalent DZ exposure, females received two DZ-filled pellets, while males received three (Wilson and Biscardi 1992). The acute exposure (3 days) replicates work previously done in our laboratory (Wilson and Biscardi 1992;Wilson et al 1996) and others (Gallager et al 1985) using this method.…”

Section: Drug Treatmentsmentioning

confidence: 78%

“…To achieve equivalent DZ exposure, females received two DZ-filled pellets, while males received three (Wilson and Biscardi 1992). The acute exposure (3 days) replicates work previously done in our laboratory (Wilson and Biscardi 1992;Wilson et al 1996) and others (Gallager et al 1985) using this method. Chronic DZ animals were implanted with an additional capsule at 10 days to maintain constant drug levels throughout the treatment period (Gallager et al 1985).…”

Section: Drug Treatmentsmentioning

confidence: 78%

“…Both CORT and adrenocorticotropin hormone (ACTH) levels are greater in female rats than males following stressor exposure (Kitay 1961;Aloisi et al 1994;Wilson and Biscardi 1994). Both acute and chronic DZ pre-treatment have also been reported to attenuate CORT and ACTH levels in a sexually dimorphic manner (Pericic et al 1984;DeSouza 1990;Wilson and Biscardi 1992). Metabolites of CORT have been reported to modulate GABA/BZ responses and behavioral responding on anxiety-related tasks (Majewska 1990).…”

Section: Introductionmentioning

confidence: 96%

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A lack of tolerance to the anxiolytic effects of diazepam on the plus-maze: comparison of male and female rats

et al. 2000

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The findings from these experiments suggest that tolerance to the anxiolytic effects of DZ did not develop in males or females, and that the hormonal status of the animal does not significantly alter the anxiolytic effects of DZ following either acute or chronic exposure. Following plus-maze exposure, females had significantly higher corticosterone levels than males and acute DZ treatment diminished this stress response.

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Section: Drug Treatmentsmentioning

confidence: 78%

Section: Drug Treatmentsmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 96%

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A lack of tolerance to the anxiolytic effects of diazepam on the plus-maze: comparison of male and female rats

et al. 2000

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“…As with the bCCt, the magnitude of suppression of either reinforcers with naltrexone was similar in both male and female rats. This is important in light of the fact that both GABA and opioid systems have been reported to show fluctuations due to gonadal steroid hormones in mature rodents (Wilson and Biscardi, 1992;Wilson, 1992; for a review, see Carroll et al, 2002). In any event, these data clearly suggest that EtOHmaintained responding is more sensitive than sucrose responding to the suppressant effects of naltrexone in the CeA.…”

Section: Discussionmentioning

confidence: 91%

GABAA and Opioid Receptors of the Central Nucleus of the Amygdala Selectively Regulate Ethanol-Maintained Behaviors

Foster

McKay

Seyoum

et al. 2003

Neuropsychopharmacol

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The present study tested the hypothesis that GABA A and opioid receptors within the central nucleus of the amygdala (CeA) regulate ethanol (EtOH), but not sucrose-maintained responding. To accomplish this, bCCt, a mixed benzodiazepine (BDZ) agonist-antagonist with binding selectivity at the a1 subunit-containing GABA A receptor, and the nonselective opioid antagonist, naltrexone, were bilaterally infused directly into the CeA of alcohol-preferring rats. The results demonstrated that in HAD-1 and P rat lines, bCCt (5-60 mg) reduced EtOH-maintained responding by 56-89% of control levels. On day 2, bCCt (10-40 mg) continued to suppress EtOH maintained responding in HAD-1 rats by as much as 60-85% of control levels. Similarly, naltrexone (0.5-30 mg) reduced EtOH-maintained responding by 56-75% of control levels in P rats. bCCt and naltrexone exhibited neuroanatomical and reinforcer specificity within the CeA. Specifically, no effects on EtOH-maintained responding were observed following infusion into the caudate putamen (CPu), a locus several millimeters dorsal to the CeA. Additionally, responding maintained by sucrose, when presented concurrently with ethanol (EtOH) or presented alone, was not altered by bCCt. Naltrexone reduced sucrose-maintained responding only under the 5 mg dose condition when sucrose was presented alone, however, it did not alter sucrose responding when given concurrently with EtOH. These results support the hypothesis that GABA A and opioid receptors within the CeA can selectively regulate EtOH-maintained responding. The CeA may represent a novel target site in the development of prototypical GABA A and opioidergic receptor ligands, which selectively reduce alcohol abuse in humans.

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“…Second, administration of 3␣,5␣-THP (2.5 mg sc) prior to perforant pathway stimulation reduces ictal activity, enhances recovery of function, and prevents hippocampal damage (Frye, 1995). Third, in female rats, P attenuates the induction of seizures produced by the GABA antagonist, bicuculline (Wilson, 1992;Wilson & Biscardi, 1992), just as 3␣,5␣-THP protects against pentylenetetrazol-induced seizures (Finn & Gee, 1994). Both P and 3␣,5␣-THP similarly increase latency to focal epileptic seizures in cats (Tauboll & Lindstrom, 1993).…”

mentioning

confidence: 97%

Prenatal stress reduces the effectiveness of the neurosteroid 3?,5?-THP to block kainic-acid-induced seizures

Frye

Bayon

1999

Dev. Psychobiol.

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Effects of gender and gonadectomy on responses to chronic benzodiazepine receptor agonist exposure in rats

Cited by 33 publications

References 34 publications

A lack of tolerance to the anxiolytic effects of diazepam on the plus-maze: comparison of male and female rats

A lack of tolerance to the anxiolytic effects of diazepam on the plus-maze: comparison of male and female rats

GABAA and Opioid Receptors of the Central Nucleus of the Amygdala Selectively Regulate Ethanol-Maintained Behaviors

Prenatal stress reduces the effectiveness of the neurosteroid 3?,5?-THP to block kainic-acid-induced seizures

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