Effects of general and spinal anesthetic techniques on endothelial adhesion molecules in cesarean section

Abstract

BackgroundThe aim of this study was to investigate the effects of anesthetic techniques used during general anesthesia (GA) and spinal anesthesia (SA) on endothelial adhesion molecules in the fetal circulation of healthy parturients undergoing elective cesarean section.MethodsPatients were randomly assigned to either the general anesthesia (n = 20) or spinal anesthesia (n = 20) group. Maternal and cord blood neopterin, sE-selectin, and sL-selectin levels were measured in both groups.ResultsCord blood neopterin concentrations in the SA group were not different from those in the GA group, but maternal neopterin levels in the SA group were different from those in the GA group. Maternal blood levels of sE-selectin and sL-selectin were not different between the two groups. Similarly, the cord blood levels of sE-selectin and sL-selectin were not different between the two groups. We found an increased inflammatory process in the fetal circulation depending on the anesthetic method used.ConclusionsThese results indicate the effects of general and spinal anesthetic techniques on serum sL-selectin, sE-selectin, and neopterin levels in neonates and parturients undergoing elective cesarean section. sE-selectin and neopterin concentrations and leukocyte counts were higher in the fetal circulation than in the maternal circulation during both GA and SA.

Effect of General and Spinal Anesthesia on Hepatic and Renal functions and Hemodynamic parameters of Iraqi Women Undergo Cesarean Section: Comparative Study

“…Nevertheless, when the spinal anesthesia is contraindicated, the general anesthesia may be use . [10,11] Regional anesthesia is employed in 95% of births, spinal anesthesia and combined epidural and spinal anesthesia being the most usually utilized regional techniques in elective caesarean section . [12] The spinal anesthesia is generally considered as more safer and practical than general anesthesia, advantages of spinal anesthesia include less newborn exposure to medications, a reduced peril of maternal pulmonary aspiration, no risk of failed endotracheal intubation that may occur in general anesthesia and mother is awake when her baby is born.…”

General versus Neuraxial Anesthesia in Cesarean Section: A Systematic Review

“…We judged this item as unclear risk of bias in the rest eight included studies, because they did not describe detailed randomized method (8,9,11,12,14,16,17,19).…”