Effects of Genetic Polymorphism on Susceptibility to Nephrotoxic Properties of BTEXs Compounds

Neghab, Masoud; Nourozi, Mohamad Amin; Shahtaheri, Seyed Jamaled­din; Mansoori, Yaser; Bazzaz, Javad Tavakkoly

doi:10.1097/jom.0000000000001364

Cited by 9 publications

(9 citation statements)

References 34 publications

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“…38 Nevertheless, it has been shown that individuals may respond differently to these toxins under similar exposure conditions, and early clues suggest the role of individual genetic differences. 25,27,34 Our analysis showed that the T allele of ATM -rs228589 A>T was significantly more prevalent in cases than the control individuals. In AA) with a high risk of abnormal hematological indices.…”

Section: Ta B L E 3 Data On Hematological Indicesmentioning

confidence: 69%

“…It is now clear that the level of susceptibility of individuals to the effects of toxicants such as BTEXs is variable, often due to genetic differences 27,30,31,34,35 . Revealing such a genetic predisposition can be very important for exposure risk assessment and early detection and prevention of related diseases in susceptible individuals 1,30,31,36 .…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, there are some reports on the exposure to toluene, ethylbenzene, and xylene with the development of hematological abnormality 38 . Nevertheless, it has been shown that individuals may respond differently to these toxins under similar exposure conditions, and early clues suggest the role of individual genetic differences 25,27,34 …”

Section: Discussionmentioning

confidence: 99%

“…It is now clear that the level of susceptibility of individuals to the effects of toxicants such as BTEXs is variable, often due to genetic differences. 27 , 30 , 31 , 34 , 35 Revealing such a genetic predisposition can be very important for exposure risk assessment and early detection and prevention of related diseases in susceptible individuals. 1 , 30 , 31 , 36 Blood cells and bone marrow are the main cells and tissue that show the highest level of sensitivity and manifestations due to the toxic effects of BTEX compounds, 4 but the responses vary among exposed individuals, signifying the existence of an underlying genetic predisposition.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Genetic variations in ATM and H2AX loci contribute to risk of hematological abnormalities in individuals exposed to BTEX chemicals

Roshan

Mansoori

Hosseini

et al. 2022

Clinical Laboratory Analysis

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Background: Loci controlling DNA double-strand breaks (DSBs) repair play an important role in defending against the harmful health effects of benzene, toluene, ethylbenzene, and xylene (BTEX), but their gene variants may alter their repair capacity. The aim of the current study was to determine the relationship of functional polymorphisms ATM-rs228589 A>T, WRN-rs1800392 G>T and H2AX-rs7759 A>G in DBS repair loci with the abnormal hematological indices in workers who exposed to BTEXs. Methods:We included 141 cases with one or more abnormal hematological parameters, who had been occupationally exposed to BTEX chemicals and 152 controls with a similar exposure condition but without any abnormal hematological parameters. Atmospheric concentrations of BTEXs were measured and whole blood samples were taken from the participants to determine hematologic parameters and SNP genotyping.Results: Results showed that T allele of ATM-rs228589 and G allele of H2AX-rs7759 had a higher frequency in cases than controls (p = 0.012 and p = 0.001, respectively). Also, AT and TT genotypes of ATM-rs228589 and AG and GG genotypes of H2AX-rs7759 were higher in cases compared to controls. The AT and TT genotypes of ATM-rs228589 have significant associations with a risk of hematological abnormalities in the codominant (AT vs. AA, p = 0.018), dominant (AT + TT vs. AA, p = 0.010) and overdominant (AT vs. AA + TT, p = 0.037) models. The GG and AG genotypes of H2AX-rs7759 were in relation with increased risk of abnormal hematological indices under codominant (GA vs. AA, p = 0.009 & GG vs. AA, p = 0.005), dominant (AG + GG vs. AA, p = 0.001), and recessive (GG vs. AA + AG, p = 0.025) models.Conclusions: These observations may help to understand the mechanisms of BTEX hematotoxicity and identify useful biomarkers of risk assessment for workers exposed to BTEX.

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