Effects of gentamicin sulfate on the contractility of myometrium isolated from non-pregnant cows

Modulatory effect of three antibiotics on uterus bovine contractility in vitro and likely therapeutic approaches in reproduction

“…There are many studies that have evaluated the action of certain antibiotics (erythromycin, clarithromycin, neomycin, gentamicin, clindamycin, and ceftriaxone) on uterine contractility of woman, rat, and bovine, bringing a relaxing effect on myogenic activity and hormone induced [46][47][48]68]. These results support the hypothesis that antibiotics may act, in the postpartum, as a potential obstacle in the physiological process of self-cleaning, favoring the persistence of exudates and microorganisms inside the uterus.…”

“…For example, the erythromycin is able to stimulate the contraction of smooth muscle cells of the stomach and duodenum, probably by acting on the receptors of motilin [42,43] and moreover, seems to determine an increase in the amplitude and frequency of contraction even in rat's myometrium; the effect probably mediated by histamine H 1 receptors and calcium channels [44]. On the contrary, other studies have shown that erythromycin, as well as clarithromycin, neomycin, gentamicin, clindamycin, and ceftriaxone, would result in a relaxation of myometrial contractility in several species (woman, rat, and cow) [45][46][47][48].…”

Reproductive Tract Infections in Horses

“…In an in vitro study using bovine endometrium, gentamicin sulfate inhibited spontaneous, oxytocin-induced, and PGF 2a -induced myometrial contractions in a dose-dependent manner. Myometrial contractility was improved with the addition of calcium [109]. Previously, aminoglycoside antimicrobials had been shown to inhibit spontaneous myometrial activity of rat endometria [110].…”

Phytoestrogens reduce the effect of polychlorinated biphenyls on the contractility of bovine myometrium in vitro

“…However, the mechanism of phytoestrogens action on uterine contractility seems to be more complicated. Because PGF 2α stimulated myometrial contractions in cattle (Ocal et al, 2004), we assume that phytoestrogens may influence myometrial contractility indirectly, via inhibition of PGF 2α secretion. This suggestion can be supported by data that PCBs stimulate secretion of PGF 2α (Wrobel and Kotwica, 2005a) and release of arachidonic acid, a substrate to PGs production (Bae et al, 1999), in cattle endometrial and rat myometrial cells, respectively.…”