Effects of Gentamicin Sulfate on Enzyme Activities of Carbonic Anhydrase from Human Erythrocytes in Vitro and from Rat Erythrocytes in Vivo.

Beydemır, Şükrü; Çiftçi, Mehmet; Küfrevioğlu, Ömer İrfan; Büyükokuroğlu, Mehmet Emin

doi:10.1248/bpb.25.966

Cited by 50 publications

(44 citation statements)

References 17 publications

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“…In this respect, compounds of carbonic anhydrase inhibitors gain a clinical importance 17 . Carbonic anhydrase which is a widespread metaloenzyme has previously been purified and characterized from many living organisms including animals [18][19][20][21] . The isozymes of CA play important roles in different tissues 22,23 .…”

Section: Resultsmentioning

confidence: 99%

Purification of carbonic anhydrase-II from sheep liver and inhibitory effects of some heavy metals on enzyme activity

Demirdağ

Yerlikaya

Küfrevioğlu

2011

Journal of Enzyme Inhibition and Medicinal Chemistry

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Section: Resultsmentioning

confidence: 99%

Purification of carbonic anhydrase-II from sheep liver and inhibitory effects of some heavy metals on enzyme activity

Demirdağ

Yerlikaya

Küfrevioğlu

2011

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…Ertekin et al (2007) reported a significant increase in CA activity in lung fibrosis created using bleomycin in rats. Beydemir et al (2002) reported that aminoglycoside antibiotics inhibited the activity of carbonic anhydrase in low concentrations in vitro, but activated it at high concentrations in vitro. In this study, there was a decrease in the CA activity of all groups (p>0.05) as seen in Table 2.…”

Section: Blm: Bleomycinmentioning

confidence: 99%

The antioxidant effect of boric acid and CoQ10 on pulmonary fibrosis in bleomycin induced rats

Çelikezen¹,

Oto²,

Özdemir³

et al. 2015

Bitlis Eren University Journal of Science and Technology

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The purpose of this study is to investigate the antioxidant effects boric acid and CoQ10 has on pulmonary fibrosis in bleomycin induced rats. 32 wistar albino male rats were used in this study. The rats were categorised in four groups; a control group (only given normal saline), a bleomycin (BLM) group, a BLM + boric acid group, and a BLM + boric acid + CoQ10. The study period was adjusted to 30 days. Retinol, vitamin E, vitamin D, catalase, carbonic anhydrase, glucose, total protein, albumin, globulin, and total bilirubin levels were measured at the end of the study. There was a significant increase in the vitamin E levels of all groups (p<0.05). There was a statistically significant increase in the glucose level of all groups (P<0.001). There were significant decreases in albumin and total protein levels of all groups. While the significance level of the decrease in the albumin level was p<0.001, the significance level of the decrease in the total protein level was p<0.05. There was no significant difference in other biochemical parameters.

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“…Sepharose-4B-L-tyrosine-sulfanilamide was prepared according to a reported method 61 . Thus, pH of the solution was adjusted to 8.7, using solid Tris.…”

Section: Biochemical Studiesmentioning

confidence: 99%

“…Also, three catalytic forms are also known and called CA-related proteins (CARP) [54][55][56][57][58] . All isoenzymes contain a zinc ion (Zn 2+ ) located at the base of a 15 Å deep funnel-shaped active site cavity, that is, coordinated to the imidazole groups of three His residues and to the substrate H 2 O/hydroxide (ÀOH) that reacts with CO 2 [59][60][61][62][63] . Acetylcholinesterase (AChE, EC.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and inhibitory properties of some carbamates on carbonic anhydrase and acetylcholine esterase

Yılmaz

Akbaba

Özgeriş

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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A series of carbamate derivatives were synthesized and their carbonic anhydrase I and II isoenzymes and acetylcholinesterase enzyme (AChE) inhibitory effects were investigated. All carbamates were synthesized from the corresponding carboxylic acids via the Curtius reactions of the acids with diphenyl phosphoryl azide followed by addition of benzyl alcohol. The carbamates were determined to be very good inhibitors against for AChE and hCA I, and II isoenzymes. AChE inhibition was determined in the range 0.209-0.291 nM. On the other hand, tacrine, which is used in the treatment of Alzheimer's disease possessed lower inhibition effect (K i : 0.398 nM). Also, hCA I and II isoenzymes were effectively inhibited by the carbamates, with inhibition constants (K i ) in the range of 4.49-5.61 nM for hCA I, and 4.94-7.66 nM for hCA II, respectively. Acetazolamide, which was clinically used carbonic anhydrase (CA) inhibitor demonstrated K i values of 281.33 nM for hCA I and 9.07 nM for hCA II. The results clearly showed that AChE and both CA isoenzymes were effectively inhibited by carbamates at the low nanomolar levels.

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Effects of Gentamicin Sulfate on Enzyme Activities of Carbonic Anhydrase from Human Erythrocytes in Vitro and from Rat Erythrocytes in Vivo.

Cited by 50 publications

References 17 publications

Purification of carbonic anhydrase-II from sheep liver and inhibitory effects of some heavy metals on enzyme activity

Purification of carbonic anhydrase-II from sheep liver and inhibitory effects of some heavy metals on enzyme activity

The antioxidant effect of boric acid and CoQ10 on pulmonary fibrosis in bleomycin induced rats

Synthesis and inhibitory properties of some carbamates on carbonic anhydrase and acetylcholine esterase

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