The antioxidant effect of boric acid and CoQ10 on pulmonary fibrosis in bleomycin induced rats

Abstract

The purpose of this study is to investigate the antioxidant effects boric acid and CoQ10 has on pulmonary fibrosis in bleomycin induced rats. 32 wistar albino male rats were used in this study. The rats were categorised in four groups; a control group (only given normal saline), a bleomycin (BLM) group, a BLM + boric acid group, and a BLM + boric acid + CoQ10. The study period was adjusted to 30 days. Retinol, vitamin E, vitamin D, catalase, carbonic anhydrase, glucose, total protein, albumin, globulin, and total bilirubin levels were measured at the end of the study. There was a significant increase in the vitamin E levels of all groups (p<0.05). There was a statistically significant increase in the glucose level of all groups (P<0.001). There were significant decreases in albumin and total protein levels of all groups. While the significance level of the decrease in the albumin level was p<0.001, the significance level of the decrease in the total protein level was p<0.05. There was no significant difference in other biochemical parameters.

The Possible Protective Effect of Melatonin and Coenzyme Q10 on Lung Injury Induced by Bleomycin in Adult Male Albino Rats

“…In the present study co enzyme Q10 led to mild improvement in the histo-pathological changes induced by bleomycin and there was a non significant reduction in main area percent of collagen deposition and caspase-3 immuno-positive expression this is in agreement with (11) who found that boric acid and CoQ10 improved the ultra-structures of lung tissue. Also Mohamed et al detected theprotective properties of CoQ10 in regulation the autophagy pathway that give explanation by its role in prevention of lung and liver fibrosis (30) .…”

“…In this study bleomycin exerted a significant increase in MDA level compared to the control group and a significant reduction in GSH-Px activity that produced changes in biochemical analysis in lung tissue and oxidative stress. These findings are in agreement with Çelikezen et al (11) who proved that bleomycin has immunosuppressive and antineoplastic effect but also caused toxicity and changes in biochemical markers in lung in experimental animal studies. Ayman (19) showed that bleomycin induced oxidative stress by increasing lipid peroxidation.…”

“…Group III (Melatonin-treated group): rats were given bleomycin dose as in group II, then, after 24 h from that dose, rats were given melatonin at a dose of 5 mg/kg daily intraperitoneal for three weeks (10) . Group IV (Coenzyme Q10-treated group): rats were given bleomycin dose as in group II, then, after 24 h from that dose, rats were given coenzymeQ10 at a dose of 4mg/kg daily intraperitoneal for three weeks (11) . Group V (Melatonin and coenzyme Q10-treated group): rats were given bleomycin dose as in group II, then, after 24 h from that dose, rats were given combination of melatonin and coenzyme Q10 with the same dose as in group III and group IV respectively daily for three weeks.…”

Investigation of the pharmacological, behavioral and biochemical effects of boron on rats with rotenone-induced Parkinson's Disease

“…In addition, many in-vivo and in vitro studies have reported that the tube has antioxidant activity (16)(17)(18)(19). Since 96% of boron is found in the form of boric acid in organisms, boric acid was preferred as the boron component in our study.…”

Deneysel Epileptik Nöbet Modelinde, Artemisinin'in Fare Kalp ve Akciğer Dokularında Oksidatif Stress Belirteçleri Üzerine Etkisi.

“…[35] CAT is one of the antioxidant defense systems that protect the organism from the harmful effects of hydrogen peroxide. [36] It has been reported in previous studies that PTZ reduces CAT levels. [37,38] In this study, it was observed that there was a decrease in the groups treated with PTZ compared to the control group, and it was determined that ART treatment increased the CAT level in the heart tissue in a dose-dependent manner.…”