Effects of ginseng soluble dietary fiber on serum antioxidant status, immune factor levels and cecal health in healthy rats

Mei, Hua; Liu, Zhengbo; Sha, Ji-Yue; Li, Shanshan; Dong, Liang; Sun, Yinshi

doi:10.1016/j.foodchem.2021.130641

Cited by 31 publications

(27 citation statements)

References 36 publications

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“…IFN-γ has anti-infective and anti-proliferative properties and is also a key regulator of immune cell activation [ 28 , 29 ]. Currently, some plant polysaccharides have been reported to demonstrate the superior ability to promote IFN-γ secretion [ 30 , 31 ]. In addition, the results of this study demonstrate that broccoli, cabbage and asparagus powder all promoted the secretion of IFN-γ in the jejunum of mice.…”

Section: Discussionmentioning

confidence: 99%

Dietary Vegetable Powders Modulate Immune Homeostasis and Intestinal Microbiota in Mice

Zou

Zhang

et al. 2021

Foods

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As the largest immune organ of the human body, the intestine also plays a vital role in nutrient digestion and absorption. Some vegetables are considered to have improvement effects on the intestine. This experiment explored the effects of freeze-dried asparagus, broccoli and cabbage powder on the intestinal immune homeostasis and microflora of mice. Thirty-two mice were divided into four groups (n = 8), including control group (fed normal diet), asparagus group (fed normal diet with 5% asparagus power), broccoli group (fed normal diet with 5% broccoli power) and cabbage group (fed normal diet with 5% cabbage power). The experiment lasted 21 days. The results showed that the serum immunoglobulin concentration (IgA and IgM) and intestinal cytokine content (like IFN-γ and TNF-α) were increased after vegetable powder supplement. The experiment also detected that vegetable powder supplementation changed intestinal flora and their metabolites (short-chain fatty acid), which showed that the abundance of Lachnospiraceae and Bacteroides were decreased, while the abundance of Firmicutes and Lactobacillus as well as propionic acid and butyric acid contents were increased. Together, these vegetable powders, especially cabbage, changed the intestinal immune response and microbial activity of mice.

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Section: Discussionmentioning

confidence: 99%

Dietary Vegetable Powders Modulate Immune Homeostasis and Intestinal Microbiota in Mice

Zou

Zhang

et al. 2021

Foods

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“…Many of the components of the beneficial tonic herbs such as ginseng and ganoderma lucidum have prebiotic effects, such as polysaccharides. Ginseng soluble dietary fibre ( 22 ) and Lycium barbarum polysaccharides ( 23 ) can be fermented by the intestinal microbiota to produce beneficial metabolites such as short-chain fatty acids, thus promoting the growth of beneficial bacteria (e.g. lactic acid bacteria) and displaying prebiotic properties.…”

Section: Introductionmentioning

confidence: 99%

The Potential Prebiotic Berberine Combined With Methimazole Improved the Therapeutic Effect of Graves’ Disease Patients Through Regulating the Intestinal Microbiome

Han

Cen

et al. 2022

Front. Immunol.

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Graves’ disease, a typical metabolism disorder, causes diffuse goiter accompanied by ocular abnormalities and ocular dysfunction. Although methimazole (MI) is a commonly used drug for the treatment of GD, the efficacy of methimazole is only limited to the control of clinical indicators, and the side effects of MI should be seriously considered. Here, we designed a 6-month clinical trial that divided the patients into two groups: a methimazole group (n=8) and a methimazole combined with potential prebiotic berberine group (n=10). The effects of both treatments on thyroid function and treatment outcomes in patients with GD were assessed by thyroid index measurements and gut microbiota metagenomic sequencing. The results showed that the addition of berberine restored the patients’ TSH and FT3 indices to normal levels, whereas MI alone restored only FT3. In addition, TRAb was closer to the healthy threshold at the end of treatment with the drug combination. MI alone failed to modulate the gut microbiota of the patients. However, the combination of berberine with methimazole significantly altered the microbiota structure of the patients, increasing the abundance of the beneficial bacteria Lactococcus lactis while decreasing the abundance of the pathogenic bacteria Enterobacter hormaechei and Chryseobacterium indologenes. Furthermore, further mechanistic exploration showed that the addition of berberine resulted in a significant upregulation of the synthesis of enterobactin, which may have increased iron functioning and thus restored thyroid function. In conclusion, methimazole combined with berberine has better efficacy in patients with GD, suggesting the potential benefit of berberine combined with methimazole in modulating the composition of intestinal microbes in the treatment of GD, providing new strong evidence for the effectiveness of combining Chinese and Western drugs from the perspective of modulating the intestinal microbiota.

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“…A previous study showed that high-purity insoluble dietary fiber supplementation affected the proliferation of key bacteria, such as Lactobacillus and Peptostreptococcaceae and then affected the synthesis of SCFAs in mice (Lyu et al, 2022 ). Dietary fiber supplementation increased the abundance of UCG-005 in sows (Yu et al, 2020 ) and Lactobacillus in rats (Hua et al, 2021 ) and decreased the abundance of Turicibacter i n sows (Yu et al, 2021 ). Consequently, the addition of fiber to diets would appear to contribute to maintaining and enhancing the balance of intestinal bacterial numbers and diversity.…”

Section: Discussionmentioning

confidence: 99%

The Improvement of Semen Quality by Dietary Fiber Intake Is Positively Related With Gut Microbiota and SCFA in a Boar Model

et al. 2022

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Although fiber-rich diets have been positively associated with sperm quality, there have not been any studies that have examined the effects of dietary fiber and its metabolites on sperm quality in young or pre-pubescent animals. In this study, we aimed to explore the effect of dietary fiber supplementation on semen quality and the underlying mechanisms in a boar model. Sixty purebred Yorkshire weaning boars were randomly divided into the four groups (T1–T4). Groups T1, T2, and T3 boars were fed diets with different levels of fiber until reaching 160 days of age and were then fed the same diet, while group T4 boars were fed a basal diet supplemented with butyrate and probiotics. Compared with T1 boars, sperm motility and effective sperm number were significantly higher among T3 boars. Meanwhile, at 240 days of age, the acetic acid and total short-chain fatty acid (SCFA) contents in the sera of T3 and T4 boars were significantly higher than those in T1 boars. The abundance of microbiota in T2 and T3 boars was significantly higher than that in T1 boars (P < 0.01). Moreover, dietary fiber supplementation increased “beneficial gut microbes” such as UCG-005, Rumenococcus, Rikenellaceae_RC9_gut_group and Lactobacillus and decreased the relative abundance of “harmful microbes” such as Clostridium_sensu_stricto_1, Romboutsia and Turicibacter. Collectively, the findings of this study indicate that dietary fiber supplementation improves gut microbiota and promotes SCFA production, thereby enhancing spermatogenesis and semen quality. Moreover, the effects of dietary fiber are superior to those of derived metabolites.

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Effects of ginseng soluble dietary fiber on serum antioxidant status, immune factor levels and cecal health in healthy rats

Cited by 31 publications

References 36 publications

Dietary Vegetable Powders Modulate Immune Homeostasis and Intestinal Microbiota in Mice

Dietary Vegetable Powders Modulate Immune Homeostasis and Intestinal Microbiota in Mice

The Potential Prebiotic Berberine Combined With Methimazole Improved the Therapeutic Effect of Graves’ Disease Patients Through Regulating the Intestinal Microbiome

The Improvement of Semen Quality by Dietary Fiber Intake Is Positively Related With Gut Microbiota and SCFA in a Boar Model

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