Effects of ginsenoside Rg1 on expression of insulin-like growth factor-1 in brain of rats with brain contusion

Li, Wenkai; Ran, Wenbin; Su, Ying-Wen; Huang, Feihu

doi:10.3736/jcim20080907

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…The molecular components responsible for ginseng's actions are ginsenosides (28,29), which are triterpene saponins that have a rigid steroidal skeleton with sugar moieties (30,31). Among the ginsenosides, Rg1 is the most abundant and is the active ingredient of P. ginseng (32,33). Previous studies have shown Rg1 to be a functional ligand of GR (34)(35)(36).…”

mentioning

confidence: 99%

Ginsenoside Rg1, a Novel Glucocorticoid Receptor Agonist of Plant Origin, Maintains Glucocorticoid Efficacy with Reduced Side Effects

Cheng

Zhu

et al. 2011

The Journal of Immunology

102

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Glucocorticoids (GCs) are widely used to treat inflammatory diseases. However, they cause debilitating side effects, which limit the use of these compounds. In the past decade, many researchers have attempted to find so-called dissociated GCs that have separate distinct transactivation and transrepression activities. Anti-inflammation of GCs is a result of glucocorticoid receptor (GR)-mediated transactivation and transrepression in some tissues, similar to their side effects; therefore, the goal to discover a compound that has anti-inflammatory properties, but lacks the negative side effects seen with GCs, has yet to be achieved. In the present study, we introduce a plant-derived compound, ginsenoside Rg1, which possesses GC and estrogen-like activities. In this study, we show that Rg1 downmodulates LPS-induced proinflammatory cytokine release and inhibits NF-κB nuclear translocation and DNA binding activity. The negative effects on NF-κB activation are due to a decrease in IκB phosphorylation and protein stabilization. Furthermore, the inhibitory effect of Rg1 on NF-κB is GR-dependent, as small interfering RNA knockdown of GR abrogated this function. Rg1 also displayed profound inhibitory effects on LPS-induced MAPK activation. Importantly, Rg1 did not impair proliferation or differentiation of mouse osteoblasts. Finally, we show that Rg1 can effectively inhibit acute and chronic inflammation in vivo, but it does not cause hyperglycemia or osteoporosis as seen with dexamethasone. These results suggest that ginsenoside Rg1 may serve as a novel anti-inflammatory agent and may exhibit a potential profile for therapeutic intervention in inflammatory diseases.

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mentioning

confidence: 99%

Ginsenoside Rg1, a Novel Glucocorticoid Receptor Agonist of Plant Origin, Maintains Glucocorticoid Efficacy with Reduced Side Effects

Cheng

Zhu

et al. 2011

The Journal of Immunology

102

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“…Ginsenoside Rg1 can inhibit lipid peroxidation in the brain [33], improve the learning ability and memory function of rats [34], improve the spatial learning ability, reduce the size of infarction area, promote Functional recovery of brain tissue [35]. By activating Na+ and K+ ATP enzyme within synaptic corpuscle of mouse [36], Rg1 can increase the concentration of cyclic adenosine monophosphate in the hippocampus [37].…”

Section: Ginsenoside-rg1mentioning

confidence: 99%

“…thus, improve spatial learning ability [50]. Rg1 can promote brain functional recovery [51], inhibit calcium accumulation, reduce potassium loss [52], reduce neuronal and cell apoptotic death by increasing the expression of Insulin-like growth factor One (IGF-1) in the brain [53]. Rg-1 can increase neuronal survival, reduce the release of LDH, reduce the morphological changes of cells and the division of nuclear DNA.…”

Section: Ginsenoside-rg1mentioning

confidence: 99%

Neuroprotective effect of panax notoginseng saponins and its main components

Wang¹,

Wang²,

Hu³

2014

WJNS

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Stroke is the third leading cause of death and the first cause of adult disability in industrial countries [1]. It is charicaterized by hemiplegia, hemianopsia, aphasia, mouth askew and sever sequelae. It is considered that an ischemic disease without any specific treatment method and few effective drugs such as tPA (human tissue-type plasminogen activator) and Edarovone with specific therapeutic window will cause a lot of disadvantages if being used inaccurate. Root of Panax notoginseng (PN) which is one of traditional Chinese medicines (TCMs), was first found in "Shennong's Classic of Materia Medica" around 200 AD. Panax notogineng saponins(PNS) is a multi-components mixture containing ginseng and saponins as the most important bioactive components which are commonly used in clinical treatment. Also, ginseng and saponins form the main components of many herbal medicines in the market, e.g., Xueshuantong injection [2], Xuesaitong injection [3], Xuesaitong soft capsule [4] and so on. The main monomers of Panax notoginseng saponins (PNS) are Ginsenoside-Rb1, Gensenoside-Rg1, Gensenoside-Re, Gensenoside-Rd and Panax notoginseng saponins-R1 [5]. In this review, we found some important points as well as shortcomings that require special consideration. We therefore highlighted the advances in neuro-protection of PNS and its main monomers in the area of experimental research.

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Effects of ginsenoside Rg1 on expression of insulin-like growth factor-1 in brain of rats with brain contusion

Abstract: Ginsenoside Rg1 enhances the recovery of the contused brain through increasing the expression of IGF-1.

Cited by 2 publications

References 7 publications

Ginsenoside Rg1, a Novel Glucocorticoid Receptor Agonist of Plant Origin, Maintains Glucocorticoid Efficacy with Reduced Side Effects

Ginsenoside Rg1, a Novel Glucocorticoid Receptor Agonist of Plant Origin, Maintains Glucocorticoid Efficacy with Reduced Side Effects

Neuroprotective effect of panax notoginseng saponins and its main components

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