Effects of glutamic acid diethylester on synaptic transmission in the skate ampullae of Lorenzini

Akoev, G. N.; Andrianov, Yu. N.; Sherman, N. O.

doi:10.1007/bf01056622

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Glutamate and Aspartate1

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1989

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“…Among them GDEE, 2-amino-5-phosphonovaleric acid (APV) , kynurenic acid (KENYA), PDA, and D-glutamyl glycine (DGG) were significantly more potent in blocking the synapses than DAA, 2-amino-4-phosphonobutyric acid (APB), or glutamic acid dimethylester (GDME). The influence of GDEE (threshold concentration 10-6 M) supports the conclusion regarding the postsynaptic effects of amino acids (Akoev et al 1981(Akoev et al , 1987bAkoev and Andrianov 1981). This agent blocked both the background and evoked activity of the ampullae of Lorenzini and antagonized the post- synaptic amino acid induced depolarization as well (Fig.…”

Section: Glutamate and Aspartatesupporting

confidence: 65%