Effects of glutamine and curcumin on bacterial translocation in jaundiced rats

Karatepe, Oğuzhan; Acet, Ersin; Battal, Muharrem; Adaş, Gökhan; Kemik, Ahu Sarbay; Altıok, Merih; Kamali, Gulcin; Koçulu, Safiye; Catay, Atahan; Kamali, Sedat; Karahan, Servet

doi:10.3748/wjg.v16.i34.4313

Cited by 23 publications

(21 citation statements)

References 34 publications

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“…It was also reported by Kaya et al (20) that ciprofloxacin and ursodeoxycholic acid decrease BT. Furthermore, Karatepe et al (19) have recorded that glutamine and curcumin decrease BT in the rat models with obstructive jaundice.…”

Section: Discussionmentioning

confidence: 99%

“…Although the BT in bile duct ligated models was investigated before (15)(16)(17)(18)(19)(20)(21)(22), in many of them (15)(16)(17)(19)(20)(21)(22)) the effects of different materials on BT, except food with high-fa was studiedt. In previous studies, the effects of high-fat enteral nutrition on BT were studied by Luyer et al (10,11,18).…”

Section: Discussionmentioning

confidence: 99%

“…In some of them, different materials were given to the models in whom bile duct was ligated to observe their effects on BT (16)(17)(18)(19)(20)(21)(22). Erbil et al (16) have studied the effects of deoxycholate, lactulose and glutamine on BT included by obstructive jaundice.…”

Section: Introductionmentioning

confidence: 99%

“…Up to now, some studies which investigate the BT in obstructive jaundice models have been carried out (15)(16)(17)(18)(19)(20)(21)(22). In some of them, different materials were given to the models in whom bile duct was ligated to observe their effects on BT (16)(17)(18)(19)(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

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Effects on Bacterial Translocation of High-Fat Enteral Nutrition in Bile Duct Ligated Rats

Elipek¹,

Utkan²

2012

Balkan Med J

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Objective: Bacterial Translocation (BT) from the gastrointestinal system is at the center of current sepsis theories. In patients with obstructive jaundice, the absence of intraluminal bile flow causes some alterations and mucosal damage in the gut. In the present study, it was aimed to investigate the effects on BT of high-fat enteral nutrition in bile duct ligated rats. Material and Methods:In this study, a total of 28 healthy Spraque-Dawley rats, weighing 230-300 gr, were grouped into four as sham group, control group, high-fat enteral nutrition group and low-fat enteral nutrition group. The rats in all the groups were sacrificed on the seventh postoperative day The values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total and direct bilirubin were measured for biochemical evaluation. Also, samples were taken from the blood, lung, liver, spleen and mesenteric lymph nodes for microbiological evaluation. The results were calculated as CFU/gr and evaluated statistically.Results: In all bile duct ligated rats, all findings of obstructive jaundice were observed clinically (in postoperatively third day) and in the laboratory. It was determined that the lymphatic system is an essential pathway for BT, as reported by similar studies. However, it was observed in this study that the high-fat enteral nutrition may be not severely effective in reducing BT in bile duct ligated rats. The results were supported by statistical analyses. Conclusion:It was observed that high-fat enteral nutrition has no meaningful effects on reducing BT in bile duct ligated rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects on Bacterial Translocation of High-Fat Enteral Nutrition in Bile Duct Ligated Rats

Elipek¹,

Utkan²

2012

Balkan Med J

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“…The products eliminated via bile such as bilirubin increase in the systemic circulation and tissues (10,11).…”

Section: Introductionmentioning

confidence: 99%

Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:

et al. 2013

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Background: Bacterial Translocation is believed to be an important factor on mortality and morbidity in Obstructive Jaundiced.Aims: We investigated the probable or estimated positive effects of tauroursodeoxycholic acid, which has antibacterial and regulatory effects on intestinal flora, together with glutamine on BT in an experimental obstructive jaundiced rat model. Study Design: Animal experimentation.Methods: Forty adult, male, Sprague Dawley rats were used in this study. Animals were randomised and divided into five groups of eight each: sham (Sh); control (common bile duct ligation, CBDL); and supplementation groups administered tauroursodeoxycholic acid (CBDL+T), glutamine (CBDL+G), or tauroursodeoxycholic acid plus glutamine (CBDL+TG). Blood and liver, spleen, MLN, and ileal samples were taken via laparotomy under sterile conditions for investigation of bacterial translocation and intestinal mucosal integrity and hepatic function tests on the tenth postoperative day.Results: There were statistically significant differences in BT rates in all samples except the spleen of the CBDL+TG group compared with the CBDL group (p=0.041, p=0.026, and p=0.041, respectively). Conclusion:It is essential to protect hepatic functions besides maintaining intestinal mucosal integrity in the active struggle against BT occurring in obstructive jaundice. The positive effect on intestinal mucosal integrity can be increased if glutamine is used with tauroursodeoxycholic acid, which also has hepatoprotective and immunomodulatory features.

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Prevention of Late PJI

2014

Journal Orthopaedic Research

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Effects of glutamine and curcumin on bacterial translocation in jaundiced rats

Abstract: On the basis of these findings, both curcumin and glutamine are thought to be effective in preventing or reducing bacterial translocation and oxidative damage in obstructive jaundice.

Cited by 23 publications

References 34 publications

Effects on Bacterial Translocation of High-Fat Enteral Nutrition in Bile Duct Ligated Rats

Effects on Bacterial Translocation of High-Fat Enteral Nutrition in Bile Duct Ligated Rats

Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats:

Prevention of Late PJI

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