Effects of glycerol intake and body tilt on otoacoustic emissions reflect labyrinthine pressure changes in Menière’s disease

Mom, T.; Gilain, L.; Avan, Paul

doi:10.1016/j.heares.2009.01.008

Cited by 25 publications

(14 citation statements)

References 52 publications

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“…It was reported that delayed evoked and distortion product OAE amplitudes were lower in the non-affected ears of MD patients than in the healthy control subjects (21). Offering a reliable evaluation on the functional condition of the inner ear, OAE has a validity of 50% in the diagnosis of EH, and is not sufficiently sensitive and specific for MD (22).…”

Section: Otoacoustic Emissionsmentioning

confidence: 99%

Validity and Reliability of the Diagnostic Tests for Ménière's Disease

Günerı

Çakır

Mutlu

2016

Turk Arch Otorhinolaryngol

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Ménière's disease is defined as an idiopathic syndrome characterized by endolymphatic hydrops. Various tests and measurement methods have been employed for the diagnosis of Ménière's disease. These include audiological, vestibular, radiological, clinical, and biochemical tests. However, the lack of a definitive or gold standard diagnostic test sometimes complicates the process of diagnosis. Hence, the clinician should be well-experienced in deciding when to perform a test and how to interpret the results of the test. Furthermore, having the knowledge of the validity and reliability of these tests plays a critical role. This review particularly emphasizes on remarking the validity and reliability of each test performed for the diagnosis of Ménière's disease and discussing the results according to the up-to-date literature.

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Section: Otoacoustic Emissionsmentioning

confidence: 99%

Validity and Reliability of the Diagnostic Tests for Ménière's Disease

Günerı

Çakır

Mutlu

2016

Turk Arch Otorhinolaryngol

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“…To evaluate the degree of endolymphatic hydrops, several kinds of indirect measurements have been attempted [Morrison et al, 1980;Mateijsen et al, 2001;Lin et al, 2006;Mom et al, 2009]. The oldest one is electrocochleography (ECochG), in which enhancement of the summation potential relative to the action potential is considered to reflect the endolymphatic hydrops [Morrison et al, 1980;Iseli and Gibson, 2010].…”

Section: Introductionmentioning

confidence: 99%

“…However, a recent survey of members of the American Otology Society or American Neurotology Society reported that more than half of respondents did not use ECochG at all due to a variability in results and a lack of correlation with patients' symptoms [Nguyen et al, 2010]. Recently, the testing of vestibular-evoked myogenic potentials (VEMP) [Lin et al, 2006], otoacoustic emissions [Mom et al, 2009], perilymphatic pressure using the tympanic displacement analyzer [Mateijsen et al, 2001] and the use of three-dimensional, fluid-attenuated recovery magnetic resonance imaging with administration of an intratympanic gadolinium-based contrast agent [Fukuoka et al, 2010] have all been reported to be useful for detecting endolymphatic hydrops. However, so far, none of these tests are able to offer the appropriate levels of sensitivity and specificity to make them suitable as routine diagnostic tests.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Usefulness of Multifrequency Tympanometry for Ménière’s Disease

Sugasawa¹,

Iwasaki²,

Fujimoto³

et al. 2013

Audiol Neurotol

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Multifrequency tympanometry (MFT) is the measurement of the impedance of the middle ear transmission system at a wide range of frequencies from 200 Hz to 2 kHz. A potential use of MFT as a new diagnostic tool for detecting endolymphatic hydrops has recently been reported. However, its clinical usefulness for diagnosing Ménière’s disease (MD) remains unclear. To evaluate the clinical usefulness of MFT as a new qualitative and diagnostic test for MD, we performed MFT in 70 patients with unilateral or bilateral MD and in 29 normal control subjects. The width of double peaks in the admittance tympanograms (Y width) at 2 kHz and the resonance frequency (RF) were analyzed, and receiver operating characteristic (ROC) curves were constructed. The Y width in MD-affected ears was significantly greater than that in control ears (p < 0.001). The RF in MD-affected ears was significantly lower than that in control ears (p < 0.01). Neither the Y width nor RF had a significant relationship with hearing levels or the results of caloric and vestibular myogenic potential testings. The area under the ROC curve was 0.71 for the Y width and 0.66 for the RF. At the optimal cutoff points, the sensitivity and specificity of the Y width were 47.3 and 86.8%, respectively, and those of the RF were 41.3 and 84.2%, respectively. These results indicated that MFT is significantly associated with the presence of MD, but its diagnostic accuracy is only modest. MFT is a simple, noninvasive test, which should be considered as a complementary test in the diagnosis of MD.

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“…It suggests that manipulations of ILP and of the ear's stiffness might induce larger effects in hydropic than normal ears. To test this idea, body tilt was used by Mom et al (2009) for producing ILP changes, and the posture-related phase shifts of transient-evoked OAEs around 1 kHz were found to be three times larger in MD ears than in control and contralateral asymptomatic ears. The present work elaborates on this observation with the help of distortion-product OAEs (DPOAEs), allowing cochlear status to be monitored at a chosen frequency (here: 1 kHz) every few seconds.…”

Section: Introductionmentioning

confidence: 99%