Unstable distortion-product otoacoustic emission phase in Menière’s disease

Avan, Paul; Giraudet, Fabrice; Chauveau, Benoît; Gilain, L.; Mom, T.

doi:10.1016/j.heares.2011.03.006

Cited by 42 publications

(24 citation statements)

References 49 publications

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“…Currently, the main medical application of OAEs is checking the status of hearing. One can expect, however, a much larger potential of OAEs in the context of highly complex disorders, such as tinnitus (Geven et al 2012) or Ménière’s disease (Avan et al 2011). For example, diagnostic tests on tinnitus or Ménière’s disease that use OAEs in combination with macromechanical manipulations of the cochlea (Nubel et al 1995), such as low-frequency biasing of BM position (Scholz et al 1999), are likely to benefit from knowledge of OAE physiology.…”

Section: Discussionmentioning

confidence: 99%

High-multiple spontaneous otoacoustic emissions confirm theory of local tuned oscillators

Braun¹

2013

SpringerPlus

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Understanding the origin of spontaneous otoacoustic emissions (SOAEs) in mammals has been a challenge for more than three decades. Right from the beginning two mutually exclusive concepts were explored. After 30 years this has now resulted in two well established but incompatible theories, the global standing-wave theory and the local oscillator theory. The outcome of this controversy will be important for our understanding of inner ear functions, because local tuned oscillators in the cochlea would indicate the possibility of frequency analysis via local resonance also in mammals. A previously unexploited opportunity to gain further information on this matter lies in the occasional cases of high-multiple SOAEs in human ears, which present a large number of adjacent small frequency intervals. Here, eight healthy ears of four subjects (12 to 32 SOAEs per ear) are compared with individually simulated ears where frequency spacing was random-generated by two different techniques. Further, a group of 1000 ears was simulated presenting a mean of 21.3 SOAEs per ear. The simulations indicate that the typical frequency spacing of human SOAEs may be due to random distribution of emitters along the cochlea plus a graded probability of mutual close-range suppression between adjacent emitters. It was found that the distribution of frequency intervals of SOAEs shows no above-chance probability of multiples of the preferred minimum distance (PMD) between SOAEs and that the size of PMD is related to SOAE density. The variation in size between adjacent small intervals is not significantly different in random-generated than in measured data. These three results are not in agreement with the global standing-wave theory but are in line with the local oscillator theory. In conclusion, the results are consistent with intrinsic tuning of cochlear outer hair cells.

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Section: Discussionmentioning

confidence: 99%

High-multiple spontaneous otoacoustic emissions confirm theory of local tuned oscillators

Braun¹

2013

SpringerPlus

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“…The stimulus and data collection protocols are already described in detail by Avan et al [20]. At each body position, 5 DPOAE measurements were taken, which took approximately a total of 20 seconds of measurement time.…”

Section: Methodsmentioning

confidence: 99%

Noninvasive intracranial pressure assessment using otoacoustic emissions: An application in glaucoma

et al. 2018

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The theory that glaucoma patients have a lower intracranial pressure (ICP) than healthy subjects is a controversial one. The aim of this study was to assess ICP noninvasively by determining the relationship between distortion product otoacoustic emission (DPOAE) phase and body position and to compare this relationship between patients with primary open angle glaucoma (POAG), patients with normal tension glaucoma (NTG), and controls. The relationship was also calibrated using published data regarding invasive measurements of ICP versus body position. DPOAEs were measured in 30 controls and 32 glaucoma patients (17 POAG, 15 NTG) at the following body positions (assuming 90° as upright): 45, 30, 20, 10, 0 (supine), -10, and -20°. DPOAE phase had a clear, nonlinear relationship with body position. The mean DPOAE phase shifts between the two most extreme body positions (45 to -20°) were 73.6, 80.7, and 66.3° for healthy, POAG, and NTG, respectively (P = 0.73), and the groups showed the same, nonlinear behaviour. This indicates that there is no evidence that glaucoma patients have a reduced ICP. When calibrated with invasive data, ICP and DPOAE phase were linearly related over an ICP of 3 mmHg. This suggests that, more broadly, DPOAEs could be used in the future to monitor changes in ICP in a clinical setting and to measure dynamic changes in ICP such as diurnal fluctuations or changes induced by certain medications.

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“…In this context, inner ear disorders can inluence the OAE response characteristics [27]. The endolymphatic hydrops (conined primarily in the cochlear duct and in the saccule [15]), increase the impedance at the level of the stapes, atenuating any forward or backward acoustic energy transmissions [28].…”

Section: Oaes and MDmentioning

confidence: 99%

“…A French group, coordinated by Paul Avan, has made considerable contributions to the inluence of intralabyrinthine pressure and endolymphatic hydrops on evoked emissions [25,28,[41][42][43]. One way to understand this inluence is to assess the alterations of the TEOAE phase shift (the later is a component provided by the FFT decomposition of the TEOAE response).…”

Section: Teoaes and MDmentioning

confidence: 99%

OAEs and Meniere Disease

Hatzopoulos¹,

Ciorba²,

Corazzi³

et al. 2017

Up to Date on Meniere's Disease

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Otoacoustic emissions (OAEs) are responses originating from the inner ear. Clinically they are evoked by diferent families of acoustic stimuli, such as transient acoustic clicks, tone pips, and pure tones. Upon stimulation, the acoustic energy is transformed in the middle ear at acoustic pressure acting upon the stapes footplate. The pressure wave inside the cochlea stimulates the OAE generators and a reverse acoustic energy (the OAE response) propagates from the inner ear, through the stapes and the middle ear structures, to the tympanic membrane. Considering that the acoustic energy has to cross the middle ear structures twice, the functional status of the middle ear can inluence or atenuate considerably the OAE response. In this context, any vestibular alteration can inluence the middle ear mechanics (mainly the middle ear impedance) and consequently the OAE response characteristics. The data in the literature indicate that OAEs are very sensitive to changes in the intracranial pressure. These pressure alterations during the Meniere's hydrops phase are expressed as changes in the intralabyrinthine pressure. Other studies have presented data supporting the assumption that OAEs can adequately monitor middle ear changes induced by the presentation of the glycerol test. The data in the literature suggest that OAEs can monitor the progress of Meniere's disease using reliable indices.

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Unstable distortion-product otoacoustic emission phase in Menière’s disease

Cited by 42 publications

References 49 publications

High-multiple spontaneous otoacoustic emissions confirm theory of local tuned oscillators

High-multiple spontaneous otoacoustic emissions confirm theory of local tuned oscillators

Noninvasive intracranial pressure assessment using otoacoustic emissions: An application in glaucoma

OAEs and Meniere Disease

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