Effects of glycine, pyruvate, resveratrol, and nitrite on tissue injury and cytokine response in endotoxemic rats

Hamburger, Tim; Broecker-Preuß, Martina; Hartmann, Matthias; Schade, F. Ulrich; Groot, Herbert de; Petrat, Frank

doi:10.1016/j.jss.2013.01.024

Cited by 27 publications

(26 citation statements)

References 46 publications

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“…Moreover, nitrate and nitrite supplementation decreased leukocyte recruitment in microvascular inflammation and NSAID induced intestinal injury [19]. Treatment with nitrite was also shown to protect against lipopolysaccharide (LPS)-induced morbidity and mortality in mice [20] as well as tissue injuries in rats [21]. Together, these studies demonstrate therapeutic effects of inorganic nitrate and nitrite on disorders characterized by oxidative stress and inflammation.…”

Section: Introductionmentioning

confidence: 81%

Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism

Yang

Peleli

Zollbrecht

et al. 2015

Free Radical Biology and Medicine

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Section: Introductionmentioning

confidence: 81%

Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism

Yang

Peleli

Zollbrecht

et al. 2015

Free Radical Biology and Medicine

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“…Resveratrol was shown to protect hepatic antioxidant systems against ischemia reperfusion-induced oxidative stress, protect from oxidative DNA damage caused by hydrogen peroxide and peroxynitrite (Sayın et al, 2011;Hamburger et al, 2013) Malondialdehyde (MDA), that is a lipid peroxidation end-product, connect to the cross and cause to modification on enzyme activity and ion permeability (Lamichhane et al, 2012). Lipid peroxidation and oxidative stress are evaluated by MDA level.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effects of Resveratrol against Azoxymethane Induced Damage in Rat Liver

Gurocak

Karabulut²,

Karadağ³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: In recent years, due to modern lifestyles and exposure to chemical carcinogens, cancer cases are steadily increasing. From this standpoint, azoxymethane (AOM), a chemical carcinogen which causes de novo liver damage, and resveratrol, which is an antioxidant found in foods and protects against oxidative stress damage, are of interest. We here aimed to evaluate whether resveratrol could protect the liver tissues from the effects of AOM. Materials and Methods: The study was conducted in 4 groups, each consisting of seven rats, the first receiving only AOM (2 times per week, 5 mg/kg), group 2 AOM and resveratrol (2 times a week, 20 mg/kg), group 3 assessed only as a control and group 4 administered only resveratrol. At the end of the seventh week, the rats were sacrificed. Rat liver MDA, NO, GSH levels were analyzed biochemically, as well as the tissues being evaluated histopathologically. Results: MDA and NO increased in AOM group as signs of increased oxidative stress. The group concomitantly administered resveratrol was been found to be significantly decreased in MDA and NO levels and increased in GSH activity. However, there were no significant findings on histopathological evaluation. Conclusions: In the light of these results, resveratrol appears to exert protective effect on oxidative stress in the liver tissue due to deleterious effects of chemical carcinogens.

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“…Nitrite and nitrate concentrations, as a measure of nitric oxide, were cumulatively determined in plasma before and 5 min after ischemia by the Griess method [23] as described previously [24]. …”

Section: Methodsmentioning

confidence: 99%

Resveratrol Does Not Protect from Ischemia-Induced Acute Kidney Injury in an in Vivo Rat Model

Bienholz

Pang

Guberina

et al. 2017

Kidney Blood Press Res

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Background/Aims: The natural polyphenol resveratrol (RSV) has been shown to ameliorate ischemia/reperfusion (I/R)-induced damage. Therefore, a rat model of I/R-induced AKI equipped with intensive monitoring was utilized to examine direct renal protection by RSV in vivo. Methods: AKI was induced by bilateral renal clamping (45 min) followed by reperfusion (3 h). Solvent-free RSV was continuously infused intravenously (0.056 and 0.28 mg/kg) in a total volume of 7 ml/kg/h starting from 30 min before renal clamping. At a mean arterial blood pressure below 70 mmHg for more than 5 min, bolus injections of 0.5 ml 0.9% NaCl solution were administered repetitively (max. 5 ml/kg/h). Results: No differences could be found between normoxic control groups with/without RSV. Bilateral renal clamping and subsequent reperfusion caused a progressive rise in creatinine, cystatin C, and CK, a decrease in cellular ATP content and diuresis. Infusion of RSV increased sirtuin 1 expression after ischemia/reperfusion and was associated with decreased blood pressure during ischemia and early reperfusion accompanied by an increased requirement of bolus injections as well as with increased expression of TNFα. Conclusion: RSV did not exert protective effects on I/R-induced AKI in the present short-term in vivo rat model. The lack of protection is potentially connected to aggravation of blood pressure instability.

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Effects of glycine, pyruvate, resveratrol, and nitrite on tissue injury and cytokine response in endotoxemic rats

Cited by 27 publications

References 46 publications

Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism

Inorganic nitrite attenuates NADPH oxidase-derived superoxide generation in activated macrophages via a nitric oxide-dependent mechanism

Preventive Effects of Resveratrol against Azoxymethane Induced Damage in Rat Liver

Resveratrol Does Not Protect from Ischemia-Induced Acute Kidney Injury in an in Vivo Rat Model

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