Effects of glycinin and β-conglycinin on growth performance and intestinal health in juvenile Chinese mitten crabs (Eriocheir sinensis)

Han, Fenglu; Wang, Xiaodan; Guo, J.; Cui, Qi; Xu, Chang; Luo, Yuan; Li, Erchao; Qin, Jianguang; Chen, Liqiao

doi:10.1016/j.fsi.2018.10.013

Cited by 69 publications

(62 citation statements)

References 59 publications

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“…It has been shown β-conglycinin could reduce the growth performance of turbot, juvenile Jian carp and Chinese mitten crabs (Han et al, 2018;Li et al, 2017;Zhang et al, 2013). Similarly, feeding di- Li, Li, Kong, et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Effects of β‐conglycinin on growth performance, antioxidant capacity and immunity in Rhynchocypris lagowski Dybowski

Liang

Zhu

et al. 2020

Aquacult. Nutr.

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The aim of this study was to investigate the effects of β-conglycinin on the growth performance, immunity function, antioxidant capacity and the related gene expression of anti-oxidation and inflammation in Rhynchocypris lagowski Dybowski. Five diets containing (0, 20, 40, 60 and 80 g/kg, respectively) β-conglycinin were used to feed R. lagowski Dybowski for 56 days. These results shown that compared with the control, FW, WG, SGR, FE and PE were significantly decreased by feeding (40 ~ 80 g/ kg) β-conglycinin (p < .05); feeding (40 ~ 80 g/kg) dietary β-conglycinin caused the activities of LZM and AKP in serum, CAT in proximal intestines and hepatopancreas, GPx in intestines and hepatopancreas and T-SOD in intestines to get significantly decreased and the content of MDA in intestines and hepatopancreas to get significantly increased (p < .05); significant increase of the content of IgM in serum and significant decrease of the activities of T-SOD in hepatopancreas and the content of C3 and C4 in serum in groups with (60 ~ 80 g/kg) dietary β-conglycinin were observed (p < .05); the expressions of Nrf2, HO-1, CAT, GPx, TGF-β and IL-10 were significantly reduced, and the expressions of Keap1 and TNF-α were significantly increased by feeding (20 ~ 80 g/kg) dietary β-conglycinin in intestines and hepatopancreas (p < .05); and the expressions of IL-1β in distal intestines and hepatopancreas were significantly increased by feeding (20 ~ 80 g/kg) dietary β-conglycinin, and the expressions of IL-1β in proximal and mid-intestines were significantly increased by feeding (40 ~ 80 g/ kg) dietary β-conglycinin (p < .05). In conclusion, under the conditions of our study, more than 20 g/kg dietary β-conglycinin could affect the gene expressions of antioxidation and inflammation in R. lagowski Dybowski, and more than 40 g/kg dietary β-conglycinin could reduce the immune function and antioxidant capacity and lead to a decline in growth performance in R. lagowski Dybowski.

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Section: Discussionmentioning

confidence: 99%

Effects of β‐conglycinin on growth performance, antioxidant capacity and immunity in Rhynchocypris lagowski Dybowski

Liang

Zhu

et al. 2020

Aquacult. Nutr.

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“…In turbot and crab studies, feeding dietary β‐conglycinin showed growth performance was significantly decreased. In piglets studies, feeding dietary β‐conglycinin showed daily gain was significantly reduced (Han et al, ; Li et al, ). It indicates dietary β‐conglycinin could suppress the growth performance of young animals.…”

Section: Discussionmentioning

confidence: 99%

“…However, no significant effects were found in moisture, crude lipid and ash by dietary β‐conglycinin. Similarly, feeding dietary β‐conglycinin and glycinin could decrease the content of crude protein of crabs, but moisture, crude lipid or ash were not influenced (Han et al, ). It showed that dietary β‐conglycinin could suppress the deposition of protein in the body.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have suggested that excessive dietary β-conglycinin might decrease the villus heights in piglet intestines, decrease the activities of antioxidant enzymes in Pacific white shrimp (Litoenaeus vannamei) and crabs (Eriocheir sinensis), and cause pathological damage to the intestines in rats and piglets (Guo, Piao, Cao, Ou, & Li, 2008;Han et al, 2018;Hao, Zhan, Guo, Piao, & Li, 2009;Xie, Liu, Zeng, Jin, & Tian, 2016). Compared with extensive terrestrial animal studies, little studies have focused on the negative effects of β-conglycinin on fish health.…”

Section: Introductionmentioning

confidence: 99%

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Effects of β‐conglycinin on growth performance, antioxidant capacity and intestinal health in juvenile golden crucian carp,Carassius auratus

Liang

Zhu

et al. 2019

Aquac Res

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The objective of this study was conducted to research the effects of β‐conglycinin in the diets on the growth performance, immunity function, antioxidant capacity and intestinal health of juvenile golden crucian carp (Carassius auratus). Five diets contained respectively (0, 20, 40, 60 and 80 g/kg) β‐conglycinin, and were used to feed juvenile golden crucian carp for 56 days. Final weight, weight gain and specific growth rate were significantly reduced by dietary β‐conglycinin (20–80 g/kg). Feed efficiency and protein efficiency were significantly reduced by dietary β‐conglycinin (40–80 g/kg). In hepatopancreas, the activities of T‐SOD, ACP, ALT and T‐AOC were significantly suppressed by dietary β‐conglycinin (20–80 g/kg). The activities of LZM, AKP, CAT and GPx were significantly reduced by dietary β‐conglycinin (40–80 g/kg). The activities of protease were significantly reduced and the content of MDA was significantly increased by dietary β‐conglycinin (60–80 g/kg). In proximal intestines, the activities of protease and CAT were significantly decreased by dietary β‐conglycinin (40–80 g/kg). In mid and distal intestines, the activities of protease and CAT were significantly inhibited by dietary β‐conglycinin (20–80 g/kg). In intestines, T‐AOC and GPx were significantly declined by dietary β‐conglycinin (20–80 g/kg). In proximal and mid intestines, the content of MDA were significantly increased by dietary β‐conglycinin (40–80 g/kg). In distal intestines, the content of MDA was significantly increased by dietary β‐conglycinin (20–80 g/kg). The expression of IGF‐I was significantly decreased and the expression of IL‐1β and TNF‐α was significantly increased by dietary β‐conglycinin (20–80 g/kg). The structural integrity of intestinal tissues were damaged by dietary β‐conglycinin (20–80 g/kg), the part of intestinal villus were shed, the part of epithelial cells were separated from lamina propria. Ultimately, these results suggested dietary β‐conglycinin should be <20 g/kg in formula feed of golden crucian carp.

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“…According to (Zhang et al 2013), TNF-a significantly increased in the intestine after feeding β-conglycinin to the fish, and IL-8 and IL-1 decreased. In addition, TNF-a and IL-1 significantly increased in juvenile turbot (Li et al 2017) and Mitten crab (Han et al 2019) contained in fish species. In mouse epithelia cell treated with β-conglycinin, IL-8, IL-6, and IL-2 significantly increased (Xu et al 2010), and in other experiments using rats, IL-2 decreased and IL-4, IL-5 and TNF-α increased (Guo et al 2007).…”

Section: Tnf-α Il-8 Il-2 and Il-1 Expression By β-Conglycininmentioning

confidence: 93%

Soybean β-conglycinin Induces Intestinal Immune Responses in Chicks

Kang

Belal

Song

et al. 2020

Braz. J. Poult. Sci.

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β-conglycinin from soybean has been recognized as one of the major feed allergens. This study investigated the effects of β-conglycinin-induced allergic sensitization on chicks' small intestines. A total of 40 7-day-old (100 g) chicks were divided into four groups as control, β-conglycinin 1 h, β-conglycinin 6 h, and β-conglycinin 12 h. All treatment groups were administered 60 mg of β-conglycinin/chick and small intestine samples were collected. β-conglycinin-induced allergic sensitization marginally damages the epithelium lining of the duodenum villi and, in addition, significantly increases the accumulation of mast cells in the lamina propria and crypt of the duodenum. Moreover, the TNF-α level significantly increased in all β-conglycinin groups. IL-8 and IL-2 were significantly downregulated in the 1 h group; however, there were increases for the 6 h and 12 h groups. These results suggest that β-conglycinin may lead to an inflammatory response in the chicks' small intestines.

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Effects of glycinin and β-conglycinin on growth performance and intestinal health in juvenile Chinese mitten crabs (Eriocheir sinensis)

Cited by 69 publications

References 59 publications

Effects of β‐conglycinin on growth performance, antioxidant capacity and immunity in Rhynchocypris lagowski Dybowski

Effects of β‐conglycinin on growth performance, antioxidant capacity and immunity in Rhynchocypris lagowski Dybowski

Effects of β‐conglycinin on growth performance, antioxidant capacity and intestinal health in juvenile golden crucian carp,Carassius auratus

Soybean β-conglycinin Induces Intestinal Immune Responses in Chicks

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