Effects of glyprolines on stress-induced behavioral disorders in rats

Бадмаева, С Э; Kopylova, G. N.; Abushinova, N.N.; Samonina, G. E.; Umarova, B. A.

doi:10.1007/s11055-006-0032-x

Cited by 13 publications

(7 citation statements)

References 5 publications

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“…The effect of this peptide was similar to the effects of other neuroprotective peptides such as semax and β-casomorphin-7 developed by scientists from Moscow State University (Maslova et al, 2001 ). The authors explain the observed protective effect of Pro-Gly-Pro by its ability to normalize blood supply to organs and tissues (Badmaeva et al, 2006 ).…”

Section: Treatment Of the Consequences Of Prenatal Hypoxiamentioning

confidence: 99%

Role of Prenatal Hypoxia in Brain Development, Cognitive Functions, and Neurodegeneration

2018

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This review focuses on the role of prenatal hypoxia in the development of brain functions in the postnatal period and subsequent increased risk of neurodegenerative disorders in later life. Accumulating evidence suggests that prenatal hypoxia in critical periods of brain formation results in significant changes in development of cognitive functions at various stages of postnatal life which correlate with morphological changes in brain structures involved in learning and memory. Prenatal hypoxia also leads to a decrease in brain adaptive potential and plasticity due to the disturbance in the process of formation of new contacts between cells and propagation of neuronal stimuli, especially in the cortex and hippocampus. On the other hand, prenatal hypoxia has a significant impact on expression and processing of a variety of genes involved in normal brain function and their epigenetic regulation. This results in changes in the patterns of mRNA and protein expression and their post-translational modifications, including protein misfolding and clearance. Among proteins affected by prenatal hypoxia are a key enzyme of the cholinergic system-acetylcholinesterase, and the amyloid precursor protein (APP), both of which have important roles in brain function. Disruption of their expression and metabolism caused by prenatal hypoxia can also result, apart from early cognitive dysfunctions, in development of neurodegeneration in later life. Another group of enzymes affected by prenatal hypoxia are peptidases involved in catabolism of neuropeptides, including amyloid-β peptide (Aβ). The decrease in the activity of neprilysin and other amyloid-degrading enzymes observed after prenatal hypoxia could result over the years in an Aβ clearance deficit and accumulation of its toxic species which cause neuronal cell death and development of neurodegeneration. Applying various approaches to restore expression of neuronal genes disrupted by prenatal hypoxia during postnatal development opens an avenue for therapeutic compensation of cognitive dysfunctions and prevention of Aβ accumulation in the aging brain and the model of prenatal hypoxia in rodents can be used as a reliable tool for assessment of their efficacy.

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Section: Treatment Of the Consequences Of Prenatal Hypoxiamentioning

confidence: 99%

Role of Prenatal Hypoxia in Brain Development, Cognitive Functions, and Neurodegeneration

2018

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“…Previous studies have demonstrated that the peptides inhibit nociceptive behaviour and inflammatory response . In this regard, cyclic peptides, compared to linear peptides, have been considered to have greater potential as therapeutic agents due to their increased chemical stability .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated that the peptides inhibit nociceptive behaviour and inflammatory response. 23,24 In this regard, cyclic peptides, compared to linear peptides, have been consid- The paw oedema volume was taken at the first hour after PGE 2 (100 ng per paw), serotonin (100 lg per paw) or compound 48/80 (10 lg per paw) injection. To the control group, only saline solution (NaCl, 0.9%) was administered by the intraperitoneal (i.p.)…”

Section: Discussionmentioning

confidence: 99%

Cyclo‐Gly‐Pro, a cyclic dipeptide, attenuates nociceptive behaviour and inflammatory response in mice

Ferro

Aquino

Brito

et al. 2015

Clin Exp Pharma Physio

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The present study aimed to investigate the antinociceptive and anti-inflammatory effects of the cyclic dipeptide cyclo-Gly-Pro (CGP) in mice. Antinociceptive activity was assessed by employing different pain models, such as formalin test, acetic acid-induced writhing, hot plate test, and carrageenan-induced hyperalgesia, in mice. The number of c-Fos-immunoreactive cells in the periaqueductal gray (PAG) was evaluated in CGP-treated mice. Anti-inflammatory activity was evaluated using paw oedema induced by carrageenan, compound 48/80, serotonin, and prostaglandin E2 (PGE2) and analyzed by plethysmometry. Quantitation of myeloperoxidase (MPO) in the paw was carried out to analyze the presence of neutrophils in the tissue. Intraperitoneal injection of CGP produced a significant inhibition in both neurogenic and inflammatory phases of formalin-induced pain. The antinociceptive effect of CGP, evaluated in the acetic acid-induced writhing test, was detected for up to 6 h after treatment. Further, in the hot plate test, antinociceptive behaviour was evoked by CGP, and this response was inhibited by naloxone. Animals treated with CGP did not present changes in motor performance. In CGP-treated mice there was an increase in the number of c-Fos-positive neurons in the periaqueductal gray. In another set of experiments, CGP attenuated the hyperalgesic response induced by carrageenan. Furthermore, CGP also reduced the carrageenan-increased MPO activity in paws. In addition, CGP also reduced the paw oedema evoked by compound 48/80, serotonin, and PGE2 . Taken together, these results may support a possible therapeutic application of the cyclic dipeptide cyclo-Gly-Pro toward alleviating nociception and damage caused by inflammation conditions.

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“…Glyproline family includes simple Pro-containing peptides widely found in gelatine and collagen hydrolysates: Pro-Gly (PG), GlyPro (GP), Pro-Gly-Pro (PGP), Hyp-Gly, Gly-Hyp. Some of these peptides could cross the blood brain barrier and directly affect central nervous structures involved in organism's response to stress factors [95,96]. Several experiments have shown that PGP and GP may correct stress-induced impairments in behaviour of rats [96][97][98].…”

Section: Opioid-like Activitymentioning

confidence: 99%

“…Some of these peptides could cross the blood brain barrier and directly affect central nervous structures involved in organism's response to stress factors [95,96]. Several experiments have shown that PGP and GP may correct stress-induced impairments in behaviour of rats [96][97][98]. Glyproline peptides may also potentiate memory consolidation processes in the central nervous system [99].…”

Section: Opioid-like Activitymentioning

confidence: 99%

Marine Collagen as a Source of Bioactive Molecules: A Review

Alemán¹,

Martínez-Álvarez

2013

NPJ

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Skins, scales and bones are the major by-products of the fish-processing industry. These by-products are not regarded as ordinary saleable products and are usually discarded causing a heavy environmental impact. However, they are a good source of collagen. This collagen could be extracted and further enzymatically hydrolysed to liberate physiologically active peptides. Specifically, some collagen-derived peptides may exhibit interesting antioxidant activity, potent antihypertensive activity, antimicrobial activity against different strains of bacteria, protective effect on cartilage, or capacity to stimulate bone formation. Collagen hydrolysates from fish disposals may also exhibit other interesting activities (e.g., satiety, calciotropic, or opioid). The bioactive properties of collagen-derived peptides, and also their resistance to protein digestion, make them potential ingredients of health promoting foods.

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Effects of glyprolines on stress-induced behavioral disorders in rats

Cited by 13 publications

References 5 publications

Role of Prenatal Hypoxia in Brain Development, Cognitive Functions, and Neurodegeneration

Role of Prenatal Hypoxia in Brain Development, Cognitive Functions, and Neurodegeneration

Cyclo‐Gly‐Pro, a cyclic dipeptide, attenuates nociceptive behaviour and inflammatory response in mice

Marine Collagen as a Source of Bioactive Molecules: A Review

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