Effects of gold nanoparticles administration through behavioral and oxidative parameters in animal model of Parkinson’s disease

Córneo, Emily; Silveira, Gustavo de Bem; Scussel, Rahisa; Corrêa, Maria Eduarda Anastácio Borges; Abel, Jéssica da Silva; Luiz, Gabriel Paulino; Feuser, Paulo Emílio; Machado-de-Ávila, Ricardo Andrez

doi:10.1016/j.colsurfb.2020.111302

Cited by 23 publications

(8 citation statements)

References 40 publications

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“…The intranasal administration of saline, GNPs (2.5 mg/L), curcumin (10 mg/kg) and GNPs-curcumin (2.5 mg/L) was performed with the aid of a micropipette in a volume of 14 μl (7 μl/nostril) at a 45 angle. The doses of GNPs were selected according to previous studies 7, [19][20][21][22][23] and curcumin. [24][25][26]…”

Section: Intranasal Administrationmentioning

confidence: 99%

Green synthesis of gold nanoparticles modulates lipopolysaccharide‐induced lung inflammation in Wistar rats

Casagrande

Porto

Colares

et al. 2023

Basic Clin Pharma Tox

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This study aimed to investigate the effect of intranasal treatment of gold nanoparticles (GNPs) and Curcumin (Cur) on the lipopolysaccharide (LPS)-induced acute pulmonary inflammatory response. A single intraperitoneal injection of LPS (0.5 mg/Kg) was performed, and the animals in the Sham group were injected with 0.9% saline. Treatment was daily intranasally with GNPs (2.5 mg/L), Cur (10 mg/kg) and GNP-Cur started 12 h after LPS administration and ended on the seventh day. The results show that the treatment performed with GNP-Cur was the most effective to attenuate the action of proinflammatory cytokines, and a lower leukocyte count in the bronchoalveolar lavage, in addition to positively regulating anti-inflammatory cytokines in relation to other groups. As a result, it promoted an oxirreductive balanced environment in the lung tissue, providing a histological outcome with a reduction in inflammatory cells and greater alveolar area. The group treated with GNPs-Cur was superior to the other groups, with better anti-inflammatory activity and reduced oxidative stress, resulting in less morphological damage to lung tissue. In conclusion, the use of reduced GNPs with curcumin demonstrates promising effects in the control of the acute inflammatory response, helping to protect the lung tissue at the biochemical and morphological levels.

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Section: Intranasal Administrationmentioning

confidence: 99%

Green synthesis of gold nanoparticles modulates lipopolysaccharide‐induced lung inflammation in Wistar rats

Casagrande

Porto

Colares

et al. 2023

Basic Clin Pharma Tox

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“…The animals were divided into four classes (N = 6): sham; sham and GNP; reserpine; reserpine and GNP; C57BL/6 mice for 40 males (20-30 g). Three doses subcutaneously were administered at 48 h intervals with a reserpine concentration of 0.25 mg/kg [98]. Using light scatter absorption, fluorescence, TEM, CD spectroscopy and SDS-PAGE, the effect of gold nanoparticles made from hibiscus on the amyloid formation of alpha-lactalbumin was assessed.…”

Section: Gold Nanoparticles Effects On Amyloid Beta Peptidementioning

confidence: 99%

“…Mediated aggregation and color shift in AuNP suspension, PrP (95)(96)(97)(98)(99)(100)(101)(102)(103)(104)(105)(106)(107)(108)(109)(110), a cellular prion protein AβO-specific binding peptide, weakened AuNP's IFE to CdTe QD fluorescence and restored fluorescence power. The absorption of PrP (95-110) on the AuNP surface was prevented by the unusual interaction between AβOs and PrP (95)(96)(97)(98)(99)(100)(101)(102)(103)(104)(105)(106)(107)(108)(109)(110) in the presence of AβOs. Accumulation of AuNPs was stopped, and the fluorescence intensity of CdTe QDs was again extinguished.…”

Section: Gold Nanoparticles Effects On Amyloid Beta Peptidementioning

confidence: 99%

Potential Role of Nanoparticles in Treating the Accumulation of Amyloid-Beta Peptide in Alzheimer’s Patients

Abbas

2021

Polymers

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The disorder of Alzheimer’s is marked by progressive pathophysiological neurodegeneration. The amino acid peptides in the amyloid plaques found in the brains of people with Alzheimer’s disease (AD) are known as amyloid-beta (Aβ). Current treatments are not curative, and the effects associated with AD are reduced. Improving treatment results involved the targeting of drugs at optimum therapeutic concentration. Nanotechnology is seen as an unconventional, modern technology that plays a key role in the treatment of Alzheimer’s disease. Using nanoparticles, molecular detection, effective drug targeting, and their combination offer high sensitivity. The aim of this review is to shed light on the function and successful role of nanoparticles to resolve Aβ aggregation and thus to help cure Alzheimer’s disease. The analysis divides these nanoparticles into three categories: polymer, lipid, and gold nanoparticles. A thorough comparison was then made between the nanoparticles, which are used according to their role, properties, and size in the procedure. The nanoparticles can prevent the accumulation of Aβ during the efficient delivery of the drug to the cells to treat Alzheimer’s disease. Furthermore, this comparison demonstrated the ability of these nanoparticles to deal efficiently with Alzheimer’s disease. The role of these nanoparticles varied from delivering the drug to brain cells to dealing with the disease-causing peptide.

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“…Besides, treatment with iron (Fe) chelation NPs modified with zwitterionic poly(2-methacryloyloxyethyl phosphorylcholine) and HIV-1–transactivating transcriptor to delay its saturation in blood and increase its in vivo lifetime can reverse PD symptoms more effectively compared to individual treatments ( Wang et al, 2017 ). Further study reveals that treatment of alkaline reserpine–induced PD mouse model with Au NPs can significantly reverse behavioral defects and improve antioxidant status and neuronal survival ( da Silva Córneo et al, 2020 ). Moreover, the treatment of PD-induced mouse model with nanodopamine drugs also improves motor defects with low toxicity as compared to pure levodopa, a primary drug used for the treatment of PD ( Vong et al, 2020 ).…”

Section: Nanotechnology In Brain Diseases and Disordersmentioning

confidence: 99%

The Application of Nanotechnology for the Diagnosis and Treatment of Brain Diseases and Disorders

Ngowi

Wang

Qian

et al. 2021

Front. Bioeng. Biotechnol.

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Brain is by far the most complex organ in the body. It is involved in the regulation of cognitive, behavioral, and emotional activities. The organ is also a target for many diseases and disorders ranging from injuries to cancers and neurodegenerative diseases. Brain diseases are the main causes of disability and one of the leading causes of deaths. Several drugs that have shown potential in improving brain structure and functioning in animal models face many challenges including the delivery, specificity, and toxicity. For many years, researchers have been facing challenge of developing drugs that can cross the physical (blood–brain barrier), electrical, and chemical barriers of the brain and target the desired region with few adverse events. In recent years, nanotechnology emerged as an important technique for modifying and manipulating different objects at the molecular level to obtain desired features. The technique has proven to be useful in diagnosis as well as treatments of brain diseases and disorders by facilitating the delivery of drugs and improving their efficacy. As the subject is still hot, and new research findings are emerging, it is clear that nanotechnology could upgrade health care systems by providing easy and highly efficient diagnostic and treatment methods. In this review, we will focus on the application of nanotechnology in the diagnosis and treatment of brain diseases and disorders by illuminating the potential of nanoparticles.

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Effects of gold nanoparticles administration through behavioral and oxidative parameters in animal model of Parkinson’s disease

Cited by 23 publications

References 40 publications

Green synthesis of gold nanoparticles modulates lipopolysaccharide‐induced lung inflammation in Wistar rats

Green synthesis of gold nanoparticles modulates lipopolysaccharide‐induced lung inflammation in Wistar rats

Potential Role of Nanoparticles in Treating the Accumulation of Amyloid-Beta Peptide in Alzheimer’s Patients

The Application of Nanotechnology for the Diagnosis and Treatment of Brain Diseases and Disorders

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