Effects of gonadal hormones on pacing of sexual contacts by female rats

Gilman, Dennis P.; Hitt, John C.

doi:10.1016/s0091-6773(78)92926-7

Cited by 53 publications

(22 citation statements)

References 23 publications

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“…Proceptive behaviors involve the solicitation of sexual activity (e.g., hopping, darting, ear wiggling, and pacing), whereas receptive behaviors ensure that mating is successful (e.g., lordosis; 42). Early work documented that proceptive behaviors were controlled by progesterone, while the expression of receptive behaviors was amplified by a combination of estrogen and progesterone (56). For example, OVX and adrenalectomized females do not display proceptive or receptive behaviors when in the presence of a male.…”

Section: Sexual Behaviormentioning

confidence: 99%

A New Look at the 5?-Reductase Inhibitor Finasteride

et al. 2006

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Finasteride is the first 5á-reductase inhibitor that received clinical approval for the treatment of human benign prostatic hyperplasia (BPH) and androgenetic alopecia (male pattern hair loss). These clinical applications are based on the ability of finasteride to inhibit the Type II isoform of the 5á-reductase enzyme, which is the predominant form in human prostate and hair follicles, and the concomitant reduction of testosterone to dihydrotestosterone (DHT). In addition to catalyzing the rate-limiting step in the reduction of testosterone, both isoforms of the 5á-reductase enzyme are responsible for the reduction of progesterone and deoxycorticosterone to dihydroprogesterone (DHP) and dihydrodeoxycorticosterone (DHDOC), respectively. Recent preclinical data indicate that the subsequent 3á-reduction of DHT, DHP and DHDOC produces steroid metabolites with rapid non-genomic effects on brain function and behavior, primarily via an enhancement of ã-aminobutyric acid (GABA)ergic inhibitory neurotransmission. Consistent with their ability to enhance the action of GABA at GABA A receptors, these steroid derivatives (termed neuroactive steroids) possess anticonvulsant, antidepressant and anxiolytic effects in addition to altering aspects of sexual-and alcohol-related behaviors. Thus, finasteride, which inhibits both isoforms of 5á-reductase in rodents, has been used as a tool to manipulate neuroactive steroid levels and determine the impact on behavior. Results of some preclinical studies and clinical observations with finasteride are described in this review article. The data suggest that endogenous neuroactive steroid levels may be inversely re- 53

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Section: Sexual Behaviormentioning

confidence: 99%

A New Look at the 5?-Reductase Inhibitor Finasteride

et al. 2006

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“…The increased rate of postpartum female sexual initiation may result from higher progesterone levels. Onset of postpartum mating is concurrent with peak progesterone levels in the female (CONNOR and DAVIS 1980b), and increasing the amount of progesterone given to ovariectomized females causes an increase in female sexual initiation (e.g., faster female returns to the male following an intromission; GILMAN and HITT 1978;FADEM et al 1979). Conversely, cycling pairs began mating at lights out, when the female's progesterone levels are just beginning to rise (NEQUIN et al 1979).…”

Section: Discussionmentioning

confidence: 99%

“…The median standard errors of the autocorrelation coefficients were .14 for lags 1, 2 and 3 of postpartum data and .13 for lags 1, 2 and 3 of cycling data. No differencing was required in order for the data to assume a stationary model (GLASS et al 1975;SPSS Box-Jenkins procedure, NIE et al 1975).…”

Section: Mating Rate: Interval Between Intromissionsmentioning

confidence: 99%

The Timing of Mating by Postpartum Estrous Rats

Hedricks

McClintock

1985

Zeitschrift für Tierpsychologie

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and Summary In Norway rats (Rattus norvegicus) postpartum copulation began later, and was more rapid than mating during a cycling estrus. Faster postpartum mating was a result of shorter intervals between intromissions, rather than fewer intromissions. In addition, postpartum pairs showed a trend towards fewer ejaculatory series. Postpartum female sexual initiation and her attractiveness to the male produced rapid postpartum mating. Preliminary evidence indicates that pups' presence does not determine faster postpartum mating, yet postpartum females did exhibit time‐sharing relationships between their mating and maternal demands. We hypothesize that the rapid pace of postpartum mating is produced by intrinsic neuroendocrine changes characteristic of postpartum estrus and possibly by sexual experience.

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“…In 1982, Erskine and Baum found that not only is interintromission time dependent upon the preceding male behavior but also the interintromission periods are longer when the female can control the interaction. This phenomenon of female rats being able to escape a male rat by some kind of divided chamber has been termed ''pacing'' behavior (Gilman and Hitt, 1978). With paced mating, fewer intromissions are necessary to bring about the neuroendocrine response of luteal functioning (Gilman and Hitt, 1978), which results in progesterone secretion, the sine qua non for pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Mating Enhances Expression of Hormonal and Trophic Factors in the Midbrain of Female Rats

Frye

Chittur

2020

Front. Behav. Neurosci.

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Among female rats, mating enhances neurosteroid formation in the midbrain ventral tegmental area (VTA; independent of peripheral steroid-secreting glands, ovaries, and adrenals). The sources/targets for these actions are not well understood. In Experiment 1, proestrous rats engaged in a mating paradigm, or did not, and the midbrains had been assessed via the Affymetrix rat genome microarrays. In Experiment 2, the influence of gonadal and adrenal glands on the expression of these genes was assessed in rats that were proestrous, ovariectomized (OVX), or OVX and adrenalectomized (ADX). The microarrays revealed 53 target genes that were significantly up-regulated (>2.0-fold change) in response to mating. Mating significantly enhanced the midbrain mRNA expression of genes involved in hormonal and trophic actions: Gh1, S100g, and Klk1b3 in proestrous, but not OVX and/or ADX, rats; Fshb in all but OVX/ADX rats; and lutenizing hormone β and thyroid-stimulating hormone (TSH) β in all rats. Thus, mating enhances midbrain gene expression independent and dependent of peripheral glands.

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Effects of gonadal hormones on pacing of sexual contacts by female rats

Cited by 53 publications

References 23 publications

A New Look at the 5?-Reductase Inhibitor Finasteride

A New Look at the 5?-Reductase Inhibitor Finasteride

The Timing of Mating by Postpartum Estrous Rats

Mating Enhances Expression of Hormonal and Trophic Factors in the Midbrain of Female Rats

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