Effects of gonadotrophin deprivation on follicular growth in gilts

Driancourt, Marc Antoine; Locatelli, A.; Prunier, Armelle

doi:10.1051/rnd:19950606

Cited by 60 publications

(49 citation statements)

References 22 publications

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“…There were no differences between the treatment groups with respect to ED and WEI, with one exception: primiparous sows treated with eCG tended to have shorter WEI values. This is consistent with the results of Engl [21] and Engl et al [20], and may occur because eCG exhibits both LH-and FSH-like activities [29]; LH stimulates the growth of follicles from 4 mm to preovulatory size [30], which in turn shortens the follicular phase and thus the WEI [31].…”

Section: Paritysupporting

confidence: 91%

Effect of a GnRH analogue (Maprelin) on the reproductive performance of gilts and sows

Jong

Kauffold²,

Engl³

et al. 2013

Theriogenology

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a b s t r a c tThe ability of peforelin (l-GnRH-III) to stimulate follicular growth, FSH release, and estrus in gilts after altrenogest treatment and in sows after weaning was investigated. In three farrow-to-wean herds, with at least 600 sows and average production performance, 216 gilts, 335 primiparous, and 1299 pluriparous sows were randomly allocated to three treatments: peforelin (M group: Maprelin), eCG (F group: Folligon), and physiological saline solution (C group). Animals were treated 48 hours after their last altrenogest treatment (gilts) or 24 hours after weaning (sows). The weaning-to-estrus interval, estrus duration, estrus rate (ER), pregnancy rate, and total born (TB), live born, and stillborn (SB) numbers were recorded and compared between treatments for the different parity groups (gilts and primiparous and pluriparous sows). Follicle sizes were measured in representative animals from each group on the occasion of their last altrenogest treatment or at weaning, and also on the occasions of their first (FS1) and second (FS2) attempted inseminations. Blood samples were taken to determine FSH concentrations at weaning and 2 hours after injection, and progesterone concentrations 10 days after the first insemination attempt. The relative change in FSH concentrations was calculated. Significant differences were found for ER within 7 days of weaning in pluriparous sows (95%, 91%, and 90% for the M, F, and C groups, respectively, P ¼ 0.005). Gilts in the F-group had high TB numbers, and pluriparous sows in the M group had high SB numbers (TB gilts ¼ 13.6, 15.4, and 14.9 [P ¼ 0.02] and SB pluriparous sows ¼ 1.8, 1.4, and 1.7 [P ¼ 0.05] for the M, F, and C groups, respectively). The M group had the highest FS1 (for gilts) and FS2 (for pluriparous sows) values: FS1 ¼ 5.4, 4.9, and 4.9 mm [P ¼ 0.02] and FS2 ¼ 6.8, 5.3, and 6.3 mm [P ¼ 0.03] for the M, F, and C groups, respectively. There were no significant differences between the different treatments within each parity group with respect to any of the other variables. Overall, peforelin treatment had small but positive effects on the ER and follicle growth in certain parity groups but did not seem to affect litter sizes or FSH and progesterone levels in sows on the occasions of the corresponding examinations.

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Section: Paritysupporting

confidence: 91%

Effect of a GnRH analogue (Maprelin) on the reproductive performance of gilts and sows

Jong

Kauffold²,

Engl³

et al. 2013

Theriogenology

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“…The greater number of follicles could then respond better to PMSG (gonadotropin sharing both FSH and LH activity). Experiments of gonadotropin deprivation, using an administration of GnRH agonist or antagonist, have demonstrated that FSH and basal LH are necessary for follicular recruitment in sows (Driancourt et al, 1995;Brussow et al, 1996). It is believed (Quesnel et al, 1998) that changes in the ovulation rate may result from changes in the total number of growing follicles or in the rate of recruitment and/or selection.…”

Section: Discussionmentioning

confidence: 99%

Effect of glucose supplemented diet on natural and gonadotropin induced puberty attainment in gilts

Ziȩcik¹,

Kapelański²,

Załęska³

et al. 2002

J. Anim. Feed Sci.

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The studies were designed to assess whether a glucose-enriched diet could affect natural and/or PMSG/hCG induced puberty attainment in gilts.In Experiment 1, 145 day old crossbred gilts were randomly allocated to receive a control-standard (n=25) or glucose-supplemented diet (60 g/kg feed; n=25) for 25 days in three equal portions at 8.00, 13.00 and 18.00 h .Gilts were observed morning and afternoon for the detection of oestrus.In Experiment 2, fifty 145-155 day old prepubertal gilts were divided into two equal groups and fed for 25 days as in Experiment 1. On Day 26 of the experiment, all gilts were injected with 750 IU PMSG and 72 h later with 500 IU hCG. Three days after the last injection of gonadotropin, the gilts were slaughtered at a commercial abattoir and their reproductive tracts and carcasses were examined.Based on observations of vulval development and behavioural signs of oestrus, gilts given the glucose-enriched diet in Experiment 1 reached oestrus earlier (170.1 ±0.9 day) than the control group (175.9±1.6 day; PO.05). Also gilts given the glucose-supplemented diet showed more intense signs of oestrus than control gilts (2.8±0.4 vs 2.510.7 points, respectively; P<0.05). In Experiment 2 three gilts fed the glucose-enriched diet and three fed the control-standard diet did not respond to PMSG/hCG treatment. In the remaining animals glucose supplementation of feed increased ovulation rate (8.5±0.7 vs 6.2±0.6; PO.05) as well as ovary weight (4.9±0.5 vs 3.6±0.3 g; PO.05). Similarly, weight (356.5±23.8 vs 264.7±20.2 g) and capacity (723.0±65.8 vs 511.0+35.7 cm 3 ) of uterus were significantly (PO.01) higher in for gilts fed glucose-enriched diet than for controls.The results show that the addition of glucose to the standard diet stimulated puberty attainment and/or ovarian and reproductive tract receptiveness to PMSG/hCG in prepubertal gilts.

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“…The Antarelix dose (0.01 mg . kg -1 ) was the same as that used intravenously in gilts [4,11] and in goats [2] and subcutaneously in ewes [8]. For Cetrorelix the same dose was chosen arbitrarily.…”

Section: Treatmentsmentioning

confidence: 99%

“…In all the mares treated with Antarelix, LH secretion was strongly depressed during the 8 days of IV antagonist treatment, as in mares treated with ORG 30583 IM for 14 days during the follicular phase [28], in gilts treated with Antarelix IV for 4 or 7 days during the preovulatory period [4,11] and in macaques receiving Antarelix SC for 3 days during the preovulatory period [17]. In all mares, LH secretion began to be restored just after the end of the treatment and reached pre-treatment values 4.5 days after.…”

Section: Effects On Lh and Fshmentioning

confidence: 99%

“…Antarelix (Ac-D-Nal, D-Phe(pCI), D-Pal, Ser, Tyr, D-Hci, Leu, Lys-(iPr), Pro, D-Ala-NH 2, Teverelix, Europeptides, Argenteuil, France) is a water soluble GnRH antagonist [9], which has been tested in some domestic species: gilts [4,11], ewes [27], cows [26] and more recently in mares [33]. Cetrorelix (Ac-D-Nal, D-Phe(pCI), D-Pal, Ser, Tyr, D-Hci, Leu, Arg, (iPr), Pro, D-Ala-Nh 2, Asta Medica, Frankfurt Germany) is also a water soluble GnRH antagonist used in rodents for experimental purposes [31], in superovulated zebu calves [23], and in humans for clinical uses [1].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the effects of two GnRH antagonists on LH and FSH secretion, follicular growth and ovulation in the mare

2002

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-The effects of two GnRH antagonists were tested in order to delay and/or synchronise ovulation in mares. Five mares received Antarelix (0.01 mg . kg -1 ), 5 mares received Cetrorelix (the same dose), 5 mares (control mares) received the vehicle intravenously, twice daily, for 8 days from the day the largest follicle reached 22 mm following prostaglandin administration. Ovulation was postponed in all mares injected with Antarelix (19.4 ± 1.2 days after the beginning of the treatment) and in 2/5 mares injected with Cetrorelix (20 ± 1 days) vs. 6.2 ± 0.4 days in control mares. During the treatment, LH concentrations were strongly depressed in Antarelix and in Cetrorelix mares (1.6 ± 0.1 and 3.8 ± 0.5 ng . mL -1 respectively vs. 21 ± 2.5 ng . mL -1 in control mares). In the 3 Cetrorelix mares which ovulated during the treatment, 2 initiated their LH surge at this moment. FSH concentrations were not affected in Antarelix or in Cetrorelix mares during the treatment (11.4 ± 1.3 and 7.9 ± 0.8 ng . mL -1 respectively vs. 10.5 ± 0.8 ng . mL -1 in control mares). In conclusion, Antarelix seems more efficient than Cetrorelix for postponing ovulation in mares. The role of LH in antral follicular development before the preovulatory stage is confirmed. Reprod. Nutr. Dev. 42 (2002) [251][252][253][254][255][256][257][258][259][260][261][262][263][264] 251 mare / GnRH antagonist / ovulation / FSH / LH

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Effects of gonadotrophin deprivation on follicular growth in gilts

Abstract: Summary ― The endocrine and ovarian effects of hypophysectomy (n = 5) and gonadotrophin-releasing hormone (GnRH) antagonist administration (Antarelix) (n = 5) were studied in gilts by comparison with control animals (n = 6). All

Cited by 60 publications

References 22 publications

Effect of a GnRH analogue (Maprelin) on the reproductive performance of gilts and sows

Effect of a GnRH analogue (Maprelin) on the reproductive performance of gilts and sows

Effect of glucose supplemented diet on natural and gonadotropin induced puberty attainment in gilts

Comparison of the effects of two GnRH antagonists on LH and FSH secretion, follicular growth and ovulation in the mare

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