Effects of Gonadotrophin Releasing Hormone Administration on the Pituitary‐Ovarian Axis in Anoestrous vs Ovariectomized Bitches

Buijtels, J.J.C.W.M.; Beijerink, Niek; Kooistra, Hans S.; Dieleman, S.J.; Okkens, A.C.

doi:10.1111/j.1439-0531.2006.00714.x

Cited by 25 publications

(43 citation statements)

References 30 publications

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“…The measurement of plasma LH and FSH concentrations before and after the administration of a GnRH analogue permits assessment of the capacity of the pituitary to secrete gonadotropins under different reproductive conditions. In agreement with the findings of others, GnRH administration elicited a distinct release of LH [4,[7][8][9][10] and FSH [10]. The course of the GnRH-induced surges in FSH and LH in the anestrous bitches was comparable to what has been reported previously for spontaneous FSH and LH pulses in anestrous bitches [1].…”

Section: Discussionsupporting

confidence: 91%

“…Occasionally, it can be difficult to verify the neuter status of dogs with an unknown reproductive status [7]. Although all pre-GnRH plasma LH concentrations were higher in OVX dogs than in sexually intact dogs, measurement of circulating LH concentration in a single sample has limited potential for distinguishing between OVX and sexually intact bitches.…”

Section: Discussionmentioning

confidence: 99%

“…Knowledge about the characteristics of gonadotropin secretion after intravenous administration of a GnRH analogue in the anestrous bitch is mainly limited to LH [7], the response of which is dosage-dependent [4,8]. Furthermore, an increasing dosage-dependent response of LH to stimulation with GnRH was found in the bitch during the progression of anestrus [4], but another study revealed no apparent correlation between stage of anestrus and LH response [9].…”

Section: Introductionmentioning

confidence: 99%

“…The loss of inhibitory influence of ovarian steroids and peptides on the hypothalamic-pituitary axis causes a rapid increase in the plasma concentration of both LH [7,[11][12][13][14][15][16] and FSH [12,13,16], while there are indications that the secretion pattern of both remains pulsatile [13]. Little is known about the characteristics of gonadotropin secretory response to exogenous GnRH in the OVX bitch.…”

Section: Introductionmentioning

confidence: 99%

“…Little is known about the characteristics of gonadotropin secretory response to exogenous GnRH in the OVX bitch. Both a rise [7,11] and an unpredictable response [14] in the plasma LH concentration have been reported. So far, in OVX bitches there is no information either on GnRH-induced FSH secretion or on the concomitant secretion of FSH and LH after GnRH administration.…”

Section: Introductionmentioning

confidence: 99%

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Basal and GnRH-induced secretion of FSH and LH in anestrous versus ovariectomized bitches

et al. 2007

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The basal and gonadotropin releasing hormone (GnRH)-induced plasma concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) were studied in four anestrous and four ovariectomized (OVX) bitches. Blood samples were obtained via jugular venipuncture 40 min before and 0, 10, 20, 30, 60, 90, and 120 min after the i.v. administration of synthetic GnRH in a dose of 10 mg/kg body weight.The basal plasma FSH and LH concentrations were significantly higher in the OVX bitches than in the anestrous bitches. In the anestrous bitches, the plasma FSH concentration was significantly higher than the pretreatment level at 10, 20, and 30 min, whereas the plasma LH concentration was significantly elevated at 10 and 20 min. The maximal GnRH-induced plasma FSH concentration in the anestrous bitches did not surpass the lowest plasma FSH concentration in the OVX bitches, whereas the GnRH-induced plasma LH concentrations in the anestrous bitches overlapped with the basal plasma LH concentrations in the OVX bitches. In the OVX bitches, GnRH administration did not induce a significant change in the plasma FSH concentration, whereas the plasma LH concentration increased significantly at 10 and 20 min.In conclusion, the results of the present study indicate that in anestrous bitches GnRH challenge results in increased plasma levels of both FSH and LH, whereas in the OVX bitches, in which the basal plasma FSH and LH concentrations are higher, only a rise in the plasma LH concentration is present after GnRH stimulation. The results also suggest that a test to measure plasma concentration of FSH in single samples appears to have potential in verification of neuter status in bitches. #

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Basal and GnRH-induced secretion of FSH and LH in anestrous versus ovariectomized bitches

et al. 2007

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Endometrial polyp in a spayed female dog

Lai,

Jenkins,

Sumner

et al. 2023

Vet Record Case Reports

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Endometrial polyps are rare benign uterine masses exclusively reported in geriatric, entire, female dogs or spayed female dogs with ovarian remnant syndrome. A 12‐year‐old, female, ovariohysterectomised cocker spaniel was presented for hyporexia, progressive muco‐haemorrhagic vulval discharge, and an ultrasonographically detected caudal abdominal mass. Thoracic and abdominal computed tomography revealed that the mass originated from the uterine stump, with no evidence of metastasis. Surgical excision of the mass was performed, and histopathology of the mass was consistent with an endometrial polyp. The dog was confirmed to be neutered based on the absence of ovarian remnant found on computed tomography and during surgery, and the negative results of both anti‐Mullerian hormone test and human chorionic gonadotropin stimulated progesterone test. The dog fully recovered with complete resolution of clinical signs at 2‐week, 6‐month and 18‐month rechecks. The presenting case highlights the first reported case of an endometrial polyp in a spayed female dog.

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Anti-Müllerian hormone as a diagnostic tool for ovarian remnant syndrome in bitches

et al. 2015

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Ovariohysterectomy is a surgical procedure performed for sterilization. If part or all of an ovary remains after the surgical procedure, ovarian remnant syndrome (ORS) occurs. After revascularization of the remaining ovarian tissue, the sexual cycle of bitches and queens continues. The aim of this study was to investigate the usefulness of serum anti-Müllerian hormone (AMH) measurement for the diagnosis of ORS in bitches. Forty-six female dogs were divided into four groups: the prepubertal, unspayed, spayed, and ORS groups. The serum AMH, progesterone, and estradiol concentrations of the bitches in all groups were measured by enzyme-linked immunosorbent assay. The stage in the sexual cycle of each bitch was determined based on vaginal cytology findings and serum estradiol and progesterone levels. The mean serum AMH concentration of the unspayed bitches (4.26 ± 0.82 ng/ml) was similar to that of the bitches with ORS (4.40 ± 1.09 ng/ml). However, the difference between the mean serum AMH level of the bitches with ORS and the spayed bitches (0.28 ± 0.09 ng/ml) was significant. In conclusion, the present study has demonstrated that the serum AMH level is substantially lower in spayed than in both intact bitches and bitches with ORS. According to this result, measurement of the serum AMH level is a useful tool for diagnosis of ORS in bitches.

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Effects of Gonadotrophin Releasing Hormone Administration on the Pituitary‐Ovarian Axis in Anoestrous vs Ovariectomized Bitches

Cited by 25 publications

References 30 publications

Basal and GnRH-induced secretion of FSH and LH in anestrous versus ovariectomized bitches

Basal and GnRH-induced secretion of FSH and LH in anestrous versus ovariectomized bitches

Endometrial polyp in a spayed female dog

Anti-Müllerian hormone as a diagnostic tool for ovarian remnant syndrome in bitches

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