Effects of Green Coffee Bean Extract Supplementation on Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

Shahmohammadi, Hedayat Allah; Hosseini, Seyed Ahmad; Hajiani, Eskandar; Malehi, Amal Saki; Alipour, Meysam

doi:10.5812/hepatmon.45609

Cited by 48 publications

(68 citation statements)

References 45 publications

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“…Ultimately, 10 publications were included in this study. Of the 10 eligible articles, all 10 trials reported the influences of GCE on FBS (Fukagawa et al, 2017;Haidari, Samadi, Mohammadshahi, Jalali, & Engali, 2017;Kim et al, 2012;Ochiai et al, 2004;Park, Kim, Lee, & Lee, 2010;Roshan et al, 2018;Shahmohammadi, Hosseini, Hajiani, Malehi, & Alipour, 2017;Soga et al, 2013;Suzuki et al, 2019;Watanabe et al, 2006), and five trials reported on insulin (Fukagawa et al, 2017;Haidari et al, 2017;Park et al, 2010;Roshan et al, 2018;Shahmohammadi et al, 2017) (Figure 1).…”

Section: Study Selectionmentioning

confidence: 99%

“…The characteristics of the eligible trials are detailed in Table 1. Included papers were published between 2004 and 2019 and were conducted in different countries, including three in Iran (Haidari et al, 2017;Roshan et al, 2018;Shahmohammadi et al, 2017), five in Japan (Fukagawa et al, 2017;Ochiai et al, 2004;Soga et al, 2013;Suzuki et al, 2019;Watanabe et al, 2006), and two in Korea (Kim et al, 2012;Park et al, 2010). The treatment duration varied between 2 and 16 weeks, while daily administrated dosage of GCE ranged from 100 to 1,000 mg. Studies were conducted on both genders (Roshan et al, 2018;Shahmohammadi et al, 2017;Watanabe et al, 2006), on men (Ochiai et al, 2004;Soga et al, 2013;Suzuki et al, 2019) and on women-only (Fukagawa et al, 2017;Haidari et al, 2017;Kim et al, 2012;Park et al, 2010).…”

Section: Characteristics Of the Eligible Trialsmentioning

confidence: 99%

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The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose–response meta‐analysis of randomized controlled trials

Chen

Zhao

Wang

et al. 2020

Phytotherapy Research

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Studies regarding the influence of green coffee extract (GCE) on blood glucose levels are conflicting. Thus, we sought to conduct a meta‐analysis and systematic review of all available randomized controlled trials (RCTs) to quantify the effects of GCE and CGA intervention on blood glucose and insulin levels. We performed systematic online searches in Scopus, Web of science, and PubMed databases, from inception to July 2019. Data were combined analyzed using a random effects model (Der Simonian‐Laird method) and reported as weighted mean differences (WMD). Ten trials reported the influences of GCE on FBS and insulin and were subsequently entered into the meta‐analysis. Combined results highlighted that FBS was significantly altered after GCE consumption (WMD: −1.791 mg/dl, 95% CI −3.404, −0.177), with no significant heterogeneity among the studies (I2 = 35.0%, p = .128). However, overall results demonstrated that GCE administration did not result in any significant alteration in insulin levels (WMD: −0.925 μU/ml, 95% CI:−1.915, 0.064), with significant heterogeneity found across studies (I2 = 87.9%). In sub‐group analysis, insulin levels were significantly reduced when GCE was supplemented in dosages of ≥400 mg/day (WMD:−1.942 mg/dl, 95% CI:−1.184, −0.975; I2 = 0.0%). The results of present study support the use of GCE for the enhancement of blood glucose, while subgroup analysis highlighted significant improvements in insulin levels when GCE is supplemented in doses ≥400 mg/day.

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Section: Study Selectionmentioning

confidence: 99%

Section: Characteristics Of the Eligible Trialsmentioning

confidence: 99%

The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose–response meta‐analysis of randomized controlled trials

Chen

Zhao

Wang

et al. 2020

Phytotherapy Research

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“…Previous studies have indicated that diets containing antioxidants and antiinflammatory agents in some medicinal plants may be beneficial in the treating of NAFLD. [6][7][8] Ginger (Zingiber Officinale Roscoe) is widely used worldwide as a spice. In the past, this plant has been used to treat neurological diseases, diabetes, rheumatism, gingivitis, toothache, asthma, constipation, maldigestion and nausea and vomiting.…”

Section: Introductionmentioning

confidence: 99%

<p>Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial</p>

Rafie¹,

Hosseini²,

Hajiani³

et al. 2020

CEG

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Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders. The main causes of NAFLD are associated with insulin resistance, severe lipid metabolism disorders, oxidative stress and inflammation. Previous studies have reported that ginger has positive metabolic results. Aim: The aim of this study was to determine the effect of ginger powder supplement on lipid profiles, insulin resistance, liver enzymes, inflammatory cytokines and antioxidant status in patients with NAFLD. Methods: In this randomized clinical trial, 46 people with NAFLD were parted into two groups and subjected to the ginger or placebo capsules (3 capsules daily, each containing 500 mg of ginger or wheat flour) over 12 weeks. All patients received a diet with balanced energy and physical activity during the intervention period. Liver ultrasonography, anthropometric indices and biochemical parameters were measured before and after intervention. Results: No significant difference was found between the two groups in the baseline variables at the beginning of the study. At the end of the study, serum levels of alanine aminotransferase (ALT), total cholesterol, low-density lipoprotein (LDL-C), fasting blood glucose, and insulin resistance index (HOMA), C-reactive protein (hs-CRP), and fetuin-A in the group receiving a ginger supplement significantly decreased compared to placebo. However, there was no significant difference between the two groups in body weight, fasting insulin, HDL-C, triglyceride, adiponectin, alpha-tumor necrosis factor (TNF-α), total antioxidant capacity (TAC), gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), fatty liver index (FLI), fatty liver grade and blood pressure. Conclusion: The ginger supplement may be used as a complementary therapy along with existing therapies to reduce insulin resistance, liver enzymes and inflammation in patients with non-alcoholic fatty liver.

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“…The possible mechanisms explaining the effects of the caffeine content for the designed CFB include increased energy intake, stimulation of fatty acid release from the adipose tissue (14,15), faster regeneration of energy sources, and delayed fatigue threshold, which is possible through the preventing disturbances in the acid-base balance and reduction of glycolysis and lactic acid accumulation in the muscles (24,25). Caffeine is an ergogenic agent, which influences the release of catecholamines and prevents cellular damage through its antioxidant effects (14).…”

Section: Discussionmentioning

confidence: 99%

Effect of a Designed Compact Food Bar on Maximal Oxygen Uptake (VO2Max) and Exercise Performance in Military Athletes: A Randomized, Single-Blind, Placebo-Controlled Clinical Trial

Hadi

Mobarhan

Ranjbar

et al. 2020

Iran Red Crescent Med J

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Background: Under difficult conditions, the military need high-energy macronutrients and micronutrients during intense physical activities in order to achieve optimal fitness levels. Objectives: This randomized controlled trial aimed to assess the effects of a designed compact food bar (CFB) on the maximal oxygen uptake (VO2Max) and physical fitness in military athletes. Methods: This randomized controlled trial was conducted on 50 athletes aged 20-50 years, who were assigned into two experimental and control groups. The subjects in the compact food bar (CFB) received three packs of CFB (700 kcal each), containing functional compounds (e.g., caffeine and L-arginine), every day for 10 days. The control group consumed the regular food used in military training courses with the same daily calorie count for the same period. The exercise performance was assessed using sports tests, maximal oxygen uptake (VO2Max) as a measure of cardio-respiratory endurance in vitro, cardiopulmonary exercise tests, blood pressure, and anthropometric examinations based on the participants' body composition and physical activity. The measurements were performed using a pedometer, and the data were recorded at baseline and after the intervention. The data was then analyzed in SPSS software version 16. Results: VO2Max and some of the exercise tests, including push-up, sit-and-reach test, and jump pair length, revealed significant increases in CFB group, compared to the control group (P < 0.05). However, the concerned variable seemed to have no significant effects on the anthropometric indices (weight and body mass index) and body composition (lean body mass and body fat mass) in CFB group (P > 0.05). Conclusions: According to the findings, the consumption of the proposed CFB, in comparison to regular food, could effectively improve the exercise performance in military athletes.

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Effects of Green Coffee Bean Extract Supplementation on Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

Cited by 48 publications

References 45 publications

The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose–response meta‐analysis of randomized controlled trials

The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose–response meta‐analysis of randomized controlled trials

<p>Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial</p>

Effect of a Designed Compact Food Bar on Maximal Oxygen Uptake (VO2Max) and Exercise Performance in Military Athletes: A Randomized, Single-Blind, Placebo-Controlled Clinical Trial

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