Effects of growth hormone, insulin-like growth factor-I, and cortisol on periparturient antibody response profiles of dairy cattle

Mallard, Bonnie A.; Wagter, L.C.; Ireland, M.J.; Dekkers, Jack C. M.

doi:10.1016/s0165-2427(97)00118-9

Cited by 59 publications

(45 citation statements)

References 36 publications

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“…Thirdly, older cowswhich normally underwent more intramammary infections -are more susceptible to severe coliform mastitis [55]. Age or prior exposure to pathogens also did not influence antibody response to immunization with J5 or ovalbumin [29,56]. Together, these data suggest a quite limited role -if any -for prior natural exposure to coliform mastitis pathogens in protection against severity.…”

Section: Influence Of Prior Exposurementioning

confidence: 94%

“…Several recent studies [29,44] suggest that lymphocytes could also play an important role, but their precise function in the pathogenesis of coliform mastitis remains unclear. Two major pathways for a role of lymphocytes in the mechanism of action of J5 vaccination are explored: (1) modulation of the T cell mediated immune response; and (2) opsonizing or neutralizing effects of enhanced serum and/or milk antibody titers.…”

Section: Potential Mechanisms Of Action Of the J5 Vaccinementioning

confidence: 99%

“…Serum antibody titers in J5 vaccinated cows are generally higher than in control cows, but significant effects of lactation stage on milk and serum IgG and IgM titers have been observed in both control and J5 vaccinated cows [18,21,45,49]. Furthermore, periparturient cows can be phenotypically classified as low or high responders to immunization, based on the magnitude and kinetics of the antibody response to E. coli J5 or ovalbumin injection [29,56]. Whereas about one third of the cows responded normally, two third showed a variable degree of hyporesponsiveness to peripartum immunization [29,56].…”

Section: Effect Of Lactation Stage On Antibody Responsementioning

confidence: 99%

“…Furthermore, periparturient cows can be phenotypically classified as low or high responders to immunization, based on the magnitude and kinetics of the antibody response to E. coli J5 or ovalbumin injection [29,56]. Whereas about one third of the cows responded normally, two third showed a variable degree of hyporesponsiveness to peripartum immunization [29,56]. These findings suggest that the immune deficiency which makes cows susceptible to E. coli mastitis may therefore also impair antibody response to active immunization during early lactation.…”

Section: Effect Of Lactation Stage On Antibody Responsementioning

confidence: 99%

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Potential mechanism of action of J5 vaccine in protection against severe bovine coliform mastitis

2002

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-Coliform mastitis is one of the most difficult diseases to treat in the modern dairy industry. Curative therapy with antibiotics remains only moderately effective and depends on the stage at which the disease is treated. The most successful strategies for combating coliform mastitis appear to be prevention by hygienic management or prophylactic immunization. The severity of clinical symptoms of coliform mastitis has been shown to be reduced by immunization with the Escherichia coli J5 vaccine. However, although the J5 vaccine has been licensed in the United States for about 10 years, the immunological basis of its mechanism of action is still unknown. Until now, protection by J5 vaccination has often been explained by a straightforward mechanism of enhanced antibody production resulting in increased opsonization of coliform bacteria and lipopolysaccharides (LPS). The possibility that J5 vaccination could decrease risk factors for coliform mastitis such as impaired blood polymorphonuclear neutrophil leukocyte (PMN) diapedesis has never been investigated. This review provides arguments to support the hypothesis that J5 vaccination may reduce the severity of coliform mastitis by inducing a condition of mammary gland hyper-responsiveness, characterized by a T helper 1 (Th1) response and mediated by memory cells inside the mammary gland, finally resulting in enhanced PMN diapedesis upon an intramammary infection. dairy cow / coliform mastitis / J5 vaccine / T cell / immune response Résumé -Mécanismes d'action possibles du vaccin J5 dans la protection contre la mammite coliforme sévère de la vache laitière. La mammite coliforme est une des maladies les plus difficiles à traiter dans l'industrie laitière moderne. La thérapie curative avec des antibiotiques reste peu efficace, dépendant du stade de la maladie. Les stratégies les plus efficaces pour combattre la mammite semblent être la prévention par des mesures d'hygiène ou la prophylaxie vaccinale. La sévérité des symptômes cliniques de la mammite coliforme peut être réduite par immunisation avec le vaccin Escherichia coli J5. Cependant, alors que le vaccin J5 a été mis sur le marché aux États-Unis depuis (32) 9 2647321; fax: (32) 9 2647499; e-mail: christian.burvenich@rug.ac.be environ 10 ans, les bases immunologiques de son mécanisme d'action ne sont pas connues. Jusqu'à présent, la protection par le vaccin J5 a souvent été attribuée à un simple mécanisme de stimulation de la production d'anticorps résultant en une augmentation de l'opsonization des bactéries coliformes et des lipopolysaccharides (LPS). La possibilité que la vaccination avec J5 pourrait diminuer les facteurs de risque de la mammite coliforme, tels qu'une diapédèse insuffisante des leucocytes neutrophiles polymorphonucléaires (PMN) sanguins, n'a jamais été étudiée. Cet article de synthèse cite des arguments supportant l'hypothèse que la vaccination avec J5 pourrait réduire la sévérité de la mammite coliforme en induisant une hyper-sensibilité de la glande mammaire. Celle-ci serait caractér...

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Section: Influence Of Prior Exposurementioning

confidence: 94%

Section: Potential Mechanisms Of Action Of the J5 Vaccinementioning

confidence: 99%

Section: Effect Of Lactation Stage On Antibody Responsementioning

confidence: 99%

Section: Effect Of Lactation Stage On Antibody Responsementioning

confidence: 99%

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Potential mechanism of action of J5 vaccine in protection against severe bovine coliform mastitis

2002

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“…Cortisol is well known as a stress marker of the endocrine system. Some reports monitored cortisol level in cow's blood [6][7][8][9], and the concentration of cortisol was lower than 20 ng/mL. However, collecting blood is stressful for animals and controller.…”

Section: Introductionmentioning

confidence: 99%

Detection of Stress Hormone in the Milk for Animal Welfare Using QCM Method

Ito

Aoki

et al. 2017

Journal of Sensors

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We developed a rapid and sequential analysis system to determine stress marker in the milk. One of the famous stress markers, cortisol, was detected using our method. Quartz crystal microbalance (QCM) method with a twin sensor was used in this study. One channel detected stress marker corresponding to antigen-antibody interaction and the other channel was used as a reference to remove environmental influences. Although nonspecific adsorption was monitored on each channel, frequency difference between them was within a few Hz on the injection of sample solution. One determination cycle including regeneration step could be performed within 10 minutes. The system could detect the cortisol level from 0.1 pg/mL to 100 pg/mL. These results show that our system has a potential to check the daily feeding condition for cows in terms of animal welfare.

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Immunological Activities Associated with Milk

Kelleher

Lönnerdal

2002

Advances in Nutritional Research Volume 10

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Effects of growth hormone, insulin-like growth factor-I, and cortisol on periparturient antibody response profiles of dairy cattle

Cited by 59 publications

References 36 publications

Potential mechanism of action of J5 vaccine in protection against severe bovine coliform mastitis

Potential mechanism of action of J5 vaccine in protection against severe bovine coliform mastitis

Detection of Stress Hormone in the Milk for Animal Welfare Using QCM Method

Immunological Activities Associated with Milk

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