Effects of Halothane and Isoflurane Anaesthesia on Antioxidant Enzymes in Dogs

Yarsan, Ender; Gürkan, Mehmet Fuat; Pekcan, Zeynep; İnce, Sinan; Kumandaş, Ali

doi:10.3923/javaa.2010.2513.2516

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…In our study, MDA concentrations were not signifi cantly altered in either group, suggesting that the two anaesthetic protocols used here did not increase lipid peroxidation process. Yarsan et al [23] also found no signifi cant difference in MDA concentration between dogs anaesthetized with halothane or isofl urane. Allaouchiche et al [24] aimed to evaluate the oxidative stress in porcine bronchoalveolar lavage fl uid and blood after exposure to desfl urane, sevofl urane and propofol.…”

Section: Discussionmentioning

confidence: 91%

Influence of sevoflurane or propofol anaesthesia on oxidative stress parameters in dogs with early-stage myxomatous mitral valve degeneration. A preliminary study

et al. 2018

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The aim of this study was to investigate the effects of total intravenous anaesthesia with propofol and anaesthesia induced with propofol and maintained with sevoflurane on oxidative stress parameters in dogs with early-stage myxomatous mitral valve degeneration (MMVD). Sixteen client-owned dogs with early stage MMVD that required periodontal treatment were included in the study. After induction with propofol, anaesthesia was maintained with propofol (group P) or sevoflurane (group PS). Blood samples for determination of vitamin E, superoxide dismutase, glutathione peroxidase and malondialdehyde were collected before premedication, 5 and 60 minutes and 6 hours after induction to anaesthesia. There were no significant differences between groups in any of the oxidative stress parameters at each sampling time. Compared to basal values, vitamin E concentration decreased significantly during anaesthesia in both groups and glutathione peroxidase activity increased 60 minutes after induction to anaesthesia in PS group. Anaesthesia with propofol or with propofol and sevoflurane did not have any significant impact on oxidative stress parameters in dogs with early stage MMVD. In terms of oxidative stress, both protocols may be equally safely used in dogs with early stage MMVD.

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Section: Discussionmentioning

confidence: 91%

Influence of sevoflurane or propofol anaesthesia on oxidative stress parameters in dogs with early-stage myxomatous mitral valve degeneration. A preliminary study

et al. 2018

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“…The levels of TOS were higher in group 2 than in group 1 at 30 and 60 min after induction of anesthesia, while TAC and OSI were significantly higher in group 2 than in group 1 at 60 min after induction to anesthesia ( 42 ). Yarsan et al ( 38 ) compared the effects of halothane and isoflurane on plasma MDA concentrations in dogs. Changes were not significant; however, the MDA concentration was lower under halothane anesthesia, and levels returned to baseline within 24 hours ( 38 ).…”

Section: Inhalational Anestheticsmentioning

confidence: 99%

“…Yarsan et al ( 38 ) compared the effects of halothane and isoflurane on plasma MDA concentrations in dogs. Changes were not significant; however, the MDA concentration was lower under halothane anesthesia, and levels returned to baseline within 24 hours ( 38 ).…”

Section: Inhalational Anestheticsmentioning

confidence: 99%

A mini-review of the effects of inhalational and intravenous anesthetics on oxidative stress in dogs

Tomsič

Svete

2022

Front. Vet. Sci.

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General anesthesia increases the production of reactive oxygen species (ROS), which can exacerbate or increase oxidative stress and thus affect the prognosis of surgical procedures. Oxidative stress has been implicated in the development of cardiovascular, dermatologic, oncologic, and other diseases in dogs, as well as ischemia and reperfusion injury. Some anesthetics, such as halogenated anesthetics, have been shown to stimulate the production of ROS, while others, such as propofol, have antioxidant properties. However, the antioxidant effects of these anesthetics may not be sufficient to counteract oxidative damage at the doses used clinically. Nevertheless, the effects of anesthetics should be considered to minimize oxidative damage during anesthesia in dogs to improve the outcome of procedures requiring general anesthesia. This mini-review addresses the current knowledge on oxidative stress during inhalational and intravenous anesthesia in dogs. There is still a lack of information on the management of anesthesia in dogs with respect to oxidative stress. Further research, including comprehensive clinical studies is needed to better understand oxidative injury mechanisms and improve perioperative protocols during anesthesia in dogs.

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“…For this purpose, isoflurane and sevoflurane are among the most researched anaesthetic agents [15,39,40]. Incoming anaesthesia created by the use of many drugs with different physicochemical properties is a source of stress and trauma for the body [10,17,18,20,41]. This event increases the oxidative response and changes the balance between oxidant / antioxidant capacity in the organism in favor of oxidant capacity.…”

Section: Introductionmentioning

confidence: 99%

Effects on the Lipid Peroxidation and the Antioxidant Defense Systems of the Use of Isoflurane or Sevoflurane in Calves Undergoing Surgery

Yakan

Atakisi

2021

Acta Scientiae. Vet.

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Background: Incoming anaesthesia created by the use of many drugs with different physicochemical properties is a source of stress and trauma for the body. This event increases the oxidative response and changes the balance between oxidant/antioxidant capacity in the organism in favor of oxidant capacity. This situation is defined as oxidative stress. For these reasons, studies are conducted to determine the effects of general anaesthetic agents on oxidant and antioxidant systems in the organism. In this study, it was aimed to determine the effects of isoflurane and sevoflurane used for general anaesthesia in humans and animals on lipid peroxidation and antioxidant defense system in calves.Materials, Methods & Results: The study included 14 calves of different breeds, ages, sexes, and weighing, average 2 weeks old. The cases randomly were divided into 2 groups, the isoflurane group (group I), and the sevoflurane group (group II), and each group included 7 animals. Before general anaesthesia, 0.04 mg/kg atropine was administered intramuscularly to all animals for premedication. At 15 min after atropine administration, isoflurane was administered at an inspiratory concentration of 3-5% in group I, and sevoflurane was administered at an inspiratory concentration of 5-7% in group II, via a face mask for 15 min for the induction of anaesthesia. Endotracheal intubation was performed in all cases at the 15min of the induction period following the onset of general anaesthesia symptoms. After the induction, anaesthesia was continued at an inspiratory concentration of 1.5-3% in the isoflurane group and inspiratory concentration of 2.5-4% in the sevoflurane group. Blood samples were taken just before anaesthesia, just before skin incision, at the end of anaesthesia and surgery, and at the 24h postoperatively. The malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione (GSH) levels were measured spectrophotometrically in samples. In group I, MDA and antioxidant parameters SOD, CAT, GSH-Px, GSH did not observe a significant change in their concentrations through the study (P > 0.05). In group II, MDA value decreased significantly before incision (P < 0.05), at the end of anaesthesia and surgery compared to the pre-anaesthesia level (P < 0.001), and then although increased significantly at 24th-h postoperatively, the value was still lower than the pre-anaestesia level (P < 0.05). It was determined that SOD activity increased significantly after sevoflurane compared to pre-anaesthesia (P < 0.05) however, the increases in SOD activity detected during sevoflurane were not statistically significant (P > 0.05). During the study, a statistically insignificant increase was observed in the concentrations of CAT, GSH-Px, GSH compared to pre-anaesthesia (P > 0.05). Pre-anaesthesia values of all measured biochemical parameters did not differ significantly between groups (P > 0.05). Before skin incision, at the end of anaesthesia and surgery, and at the 24h postoperatively MDA was lower (P < 0.05) and SOD activity was higher (P < 0.05) than in group I in group II. There was no statistically significant difference between the two groups in terms of CAT, GSH-Px, GSH levels between the other measurement times (P > 0.05). Discussion: An important advantage of sevoflurane compared to currently available anaesthetics is that it provides rapid induction due to its low solubility in blood and tissues, and rapid recovery due to its low solubility in fat. This feature is proof that the side effects of sevoflurane anaesthesia are minimal. The findings of this study show that sevoflurane exposure decreases lipid peroxidation and enhances antioxidant defense. The potential effect of sevoflurane on oxidative stress may lead to its preferred clinical use of sevoflurane compared to isoflurane.

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Effects of Halothane and Isoflurane Anaesthesia on Antioxidant Enzymes in Dogs

Cited by 3 publications

References 15 publications

Influence of sevoflurane or propofol anaesthesia on oxidative stress parameters in dogs with early-stage myxomatous mitral valve degeneration. A preliminary study

Influence of sevoflurane or propofol anaesthesia on oxidative stress parameters in dogs with early-stage myxomatous mitral valve degeneration. A preliminary study

A mini-review of the effects of inhalational and intravenous anesthetics on oxidative stress in dogs

Effects on the Lipid Peroxidation and the Antioxidant Defense Systems of the Use of Isoflurane or Sevoflurane in Calves Undergoing Surgery

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