1996
DOI: 10.1016/s1044-0305(96)00109-2
|View full text |Cite
|
Sign up to set email alerts
|

Effects of heavy gases on the tandem mass spectra of peptide ions in the quadrupole ion trap

Abstract: Heavy gases (xenon, argon, krypton, methane) have been used to improve the performance of the quadrupole ion trap when performing collision-induced dissociation on peptides. MS/MS spectra reveal that increased amounts of internal energy can be deposited into peptide ions and more structural information can be obtained. Specifically, the pulsed introduction of the heavy gases (as reported previously by Doroshenko, V. M.; Cotter, R. J.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

3
42
1

Year Published

1999
1999
2012
2012

Publication Types

Select...
6
2

Relationship

3
5

Authors

Journals

citations
Cited by 39 publications
(46 citation statements)
references
References 23 publications
3
42
1
Order By: Relevance
“…Shown in Figures 8 and 9 are the a 4 /b 4 intensity ratios for fast excitation CID with the related conventional resonance excitation CID ratios respectively. The plot for conventional resonance excitation CID at q z ϭ 0.4 shows two linear portions for the a 4 /b 4 ratio between 0.6 and 2.2 V and 2.2 and 4 V. This is different from the CID data of leucine enkephalin previously reported which showed a linear relationship between the amount of excitation and the a 4 /b 4 ratio [14,15]. A full explanation for the observation of this non-linear plot for conventional resonance excitation CID data is beyond the scope of this paper.…”
Section: Resultscontrasting
confidence: 88%
See 1 more Smart Citation
“…Shown in Figures 8 and 9 are the a 4 /b 4 intensity ratios for fast excitation CID with the related conventional resonance excitation CID ratios respectively. The plot for conventional resonance excitation CID at q z ϭ 0.4 shows two linear portions for the a 4 /b 4 ratio between 0.6 and 2.2 V and 2.2 and 4 V. This is different from the CID data of leucine enkephalin previously reported which showed a linear relationship between the amount of excitation and the a 4 /b 4 ratio [14,15]. A full explanation for the observation of this non-linear plot for conventional resonance excitation CID data is beyond the scope of this paper.…”
Section: Resultscontrasting
confidence: 88%
“…Shown in It has been reported that the intensity ratio of the a 4 /b 4 fragment ions for leucine enkephalin gives a gauge of the internal energy deposited onto the MH ϩ ion of the peptide [14,15]. Shown in Figures 8 and 9 are the a 4 /b 4 intensity ratios for fast excitation CID with the related conventional resonance excitation CID ratios respectively.…”
Section: Resultsmentioning
confidence: 99%
“…Several researchers have also explored the option of mixed gases [7][8][9][10][11]. In most cases, the heavy gas was added to the standard operating pressure of He buffer gas.…”
mentioning
confidence: 99%
“…After the experiments with static pressures of heavy buffer gases indicated the loss in resolution, two research groups investigated the use of pulsed heavy gases [8,13]. In these experiments, the standard operating pressure of He was always present.…”
mentioning
confidence: 99%
“…The experimental components were the same as those reported previously [14,15]. The duration of the pulse was 1500 sec, with an argon backing pressure of approximately 1 bar, yielding a peak argon number density approximately equal to the helium bath gas number density.…”
Section: Methodsmentioning
confidence: 99%