Effects of Helicobacter pylori Infection on Gut Appetite Peptide (Leptin, Ghrelin) Expression in Elderly Inpatients

Abstract

The aim of the study was to investigate the relationship between gastritis and leptin and ghrelin in elderly patients. Patients older than 75 years undergoing an endoscopy were included. We reported data on nutritional status and Helicobacter pylori infection diagnosis (serology, 13C-urea breath test, culture, histology, and polymerase chain reaction on gastric biopsies). Gastric messenger RNA expression of leptin and ghrelin were quantified by real-time polymerase chain reaction. Sixty-two patients were included (84.7 +/- 5.2 years). H. pylori infection was associated with decreased gastric expression of leptin (p = .021), ghrelin (p =.002), and plasma ghrelin levels (p = .018). Atrophy was associated with decreased gastric leptin (p = .007) and ghrelin (p = .02). H. pylori infection correlated negatively with patient energy intake (r = -0.36; p = .001) and body mass index (r = -0.34; p = .018). The negative association between ghrelin and H. pylori infection may be related to a higher prevalence of atrophy and raises the possibility that H. pylori may be contributing to undernutrition in some older people.

Study of Association Between Atrophic Gastritis and Body Mass Index: A Cross-Sectional Study in 10,197 Japanese Subjects

“…Nishi et al reported that subjects with H. pylori had higher levels of gastric leptin than those without H. pylori [33]. In contrast, Salles et al reported that H. pylori infection decreased gastric expression of leptin [34]. They also reported that severity of gastric atrophy correlated with decrease in gastric leptin expression, which makes changes in leptin an unlikely explanation for the association between atrophic gastritis and BMI.…”

Helicobacter pylori Infection as a Risk Factor for Insulin Resistance

“…Several studies have showed association of serum leptin and H. pylori infection [31]. Lankarani et al [32] reported that serum leptin level was significantly higher in patients with H. pylori infection.…”

The Effect of Laparoscopic Gastric Banding Surgery on Plasma Levels of Appetite-Control, Insulinotropic, and Digestive Hormones

“…H. pylori-positive subjects have been reported to have lower gastric and circulating ghrelin and leptin levels [29][30][31][32][33]. Whether weight loss or gastric hormonal function after LAGB is related to H. pylori status has not been examined.…”