Study of Association Between Atrophic Gastritis and Body Mass Index: A Cross-Sectional Study in 10,197 Japanese Subjects

Watabe, Hirotsugu; Mitsushima, Toru; Derakhshan, Mohammad H.; Yamaji, Yutaka; Okamoto, Makoto; Kawabe, Takao; Omata, Masao; McColl, Kenneth E.L.

doi:10.1007/s10620-008-0468-7

Cited by 24 publications

(16 citation statements)

References 41 publications

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“…Furthermore, some reports suggested that AG, but not HP infection status, is associated with BMI [21, 22]. Because most of AG were induced by HP infection, the results mean the effect of HP infection on BMI occur by way of AG.…”

Section: Introductionmentioning

confidence: 99%

Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome

et al. 2016

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BackgroundHelicobacter pylori (HP) infection is implicated in gastric and extra-gastric diseases. While gastritis-related chronic inflammation represents a known trigger of metabolic disturbances, whether metabolic syndrome (MetS) is affected by gastritis status remains unclear. We aimed to clarify the effect of HP-related gastritis on the risk of MetS.Materials and MethodsWe retrospectively enrolled patients undergoing screening for MetS between 2014 and 2015. Investigations included HP-specific immunoglobulin G (IgG) antibody assays to detect HP infection, and serum pepsinogen assays to evaluate atrophic gastritis status. The risk of MetS was evaluated via multiple logistic regression analyses with two covariates: serum HP infection status (IgG levels) and atrophic gastritis status (two criteria were applied; pepsinogen I/II ratio < 3 or both pepsinogen I levels ≤ 70 μg/L and pepsinogen I/II ratio < 3).ResultsOf 1,044 participants, 247 (23.7%) were HP seropositive, and 62 (6.0%) had MetS. HP seronegative and seropositive patients had similar risks of MetS. On the other hand, AG (defined in terms of serum PG I/II <3) was significant risk of MetS (OR of 2.52 [95% CI 1.05–7.52]). After stratification according to HP IgG concentration, patients with low HP infection status had the lowest MetS risk (defined as an odds ratio [OR] adjusted for age, sex, smoking, drinking and physical activity status). Taking this result as a reference, patients with negative, moderate, and high HP infection status had ORs (with 95% confidence intervals [CI]) of 2.15 (1.06–4.16), 3.69 (1.12–16.7), and 4.05 (1.05–26.8).ConclusionsHP-associated gastritis represents a risk factor for MetS. Research should determine why low and not negative HP infection status is associated with the lowest MetS risk.

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Section: Introductionmentioning

confidence: 99%

Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome

et al. 2016

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“…We presume, however, that the influence of H. Pylori infection might be moderate in this study, because the prevalence of gastric ulcers and ulcer scars, which are closely associated with H. pylori infection, was comparable in participants with and without EEG. Two studies by Japanese investigators reported that BMI is not associated with H. pylori infection status, supporting this speculation [36,37].…”

Section: Discussionmentioning

confidence: 83%

Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis

et al. 2011

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“…Among these H. pylori-related diseases, AG is more common than PUD or early gastric cancer; in Japan, its prevalence is reported to be approximately 27.9% even in healthy individuals [10]. 85% of AG patients were reported to have H. pylori infection [11].…”

Section: Introductionmentioning

confidence: 99%

Cost-Effectiveness Analysis of Helicobacter Pylori Diagnostic Methods in the Patients with Atrophic Gastritis

Shimbo¹,

Ohde²,

Deshpande³

2017

Gastroenterology

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Study of Association Between Atrophic Gastritis and Body Mass Index: A Cross-Sectional Study in 10,197 Japanese Subjects

Abstract: A small, inverse association between BMI and atrophic gastritis was found in the general population. In contrast, no association was observed between H. pylori seropositivity and BMI.

Cited by 24 publications

References 41 publications

Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome

Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome

Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis

Cost-Effectiveness Analysis of Helicobacter Pylori Diagnostic Methods in the Patients with Atrophic Gastritis

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