Effects of heme iron enriched peptide on iron deficiency anemia in rats

Chen, Le-qun; Zhuang, Hong

doi:10.1039/c3fo60292c

Cited by 40 publications

(36 citation statements)

References 55 publications

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“…The result indicated that IDA would adversely affect the growth of rats. It has been reported that the IDA rats lose their appetite [21]. From Table 3, it can be seen obviously that the food intake of the anemic rats was significantly lower than that of control rats (p < 0.05).…”

Section: Resultsmentioning

confidence: 71%

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Xiao

Lei

Wang

et al. 2015

Biol Trace Elem Res

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This study aims to investigate the effects of a tripeptide iron (REE-Fe) on iron-deficiency anemia rats. Sprague-Dawley rats were randomly divided into seven groups: a normal control group, an iron-deficiency control group, and iron-deficiency groups treated with ferrous sulfate (FeSO4), ferrous glycinate (Fe-Gly), or REE-Fe at low-, medium-, or high-dose groups. The rats in the iron-deficiency groups were fed on an iron-deficient diet to establish iron-deficiency anemia (IDA) model. After the model established, different iron supplements were given to the rats once a day by intragastric administration for 21 days. The results showed that REE-Fe had effective restorative action returning body weight, organ coefficients, and hematological parameters in IDA rats to normal level. In addition, comparing with FeSO4 or Fe-Gly, high-dose REE-Fe was more effective on improving the levels of renal coefficient, total iron-binding capacity, and transferrin. Furthermore, the liver hepcidin messenger RNA (mRNA) expression in the high-dose group was significantly higher (p < 0.05) than that in the FeSO4 or Fe-Gly group and showed no significant difference (p > 0.05) with the normal control group. The findings suggest that REE-Fe is an effective source of iron supplement for IDA rats and might be exploited as a new iron fortifier.

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Section: Resultsmentioning

confidence: 71%

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Xiao

Lei

Wang

et al. 2015

Biol Trace Elem Res

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“…Peptide–iron complexes can be absorbed in the form of soluble chelates as a whole and maintain it in the ferrous form in digestive condition. Ferrous irons could be effectively released across the apical membrane of the intestinal epithelium, thus chelates enhance the iron bioavailability . In summary, a significantly higher or equal hematological value for the middle dose DPs‐Fe group was observed during repletion, as compared with the FeSO 4 group, which could provide evidence that DPs‐Fe was more effective in overcoming IDA than FeSO 4 .…”

Section: Resultsmentioning

confidence: 78%

“…The process of dietary iron absorption in the duodenum are as follows: (i) the reduction of ferric iron to ferrous iron form occurs possibly by duodenal cytochrome b (Dcytb) on the apical surface of enterocytes; (ii) ferrous iron is further transported via the divalent metal transporter 1 (DMT1) into intestinal epithelial cells; (iii) once ferrous iron enters into the cell, one is interchanged with ferritin and remains in a dynamic equilibrium, the other is transferred across the basolateral membrane into the blood circulation by ferroportin 1 (FPN1); (iv) ferrous iron is then oxidized to the ferric form by hephaestin which has ferrous oxidase activity before entering the circulation by binding to the transferrin . Many iron supplements have been developed and investigated to solve this urgent problem . Iron can be supplied from inorganic iron salts, organic acid iron salts, amino acid‐iron chelates, peptide‐iron chelates.…”

Section: Introductionmentioning

confidence: 99%

Effect of duck egg white peptide‐ferrous chelate on iron bioavailability in vivo and structure characterization

Shi

et al. 2018

J Sci Food Agric

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BACKGROUND In order to utilize the industrial by‐product ‘salted duck egg white’ as novel iron additives, the effects of desalted duck egg white peptides‐ferrous chelate (DPs‐Fe) on the promotion of iron uptake and the structure were investigated. RESULTS Different doses of DPs‐Fe were given and iron sulfate (FeSO4) was used as a positive control. After three weeks, hemoglobin (Hb), hematocrit (HCT), red blood cells (RBCs), mean corpuscular volume (MCV), serum iron (SI) and serum ferritin (SF) in iron‐deficiency anemia (IDA) rats could be significantly (P < 0.05) increased to the normal levels by DPs‐Fe. The gene expressions of divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1) and Hepcidin could be regulated by DPs‐Fe. Additionally, DPs‐Fe was formed during the chelation process and the structure was characterized. Eight crucial iron‐chelating peptides of duck egg white peptides (DPs) were identified by HPLC‐ESI‐MS/MS, such as Pro‐Val‐Glu‐Glu and Arg‐Ser‐Ser. It indicated that Glu, Asp, Lys, His, Ser, Cys residues might play crucial roles in the chelating of DPs with iron. CONCLUSION DPs‐Fe could be a potential iron supplement, and the Glu, Asp, Lys, His played important roles in binding iron and promoting iron uptake. This research expands the understanding of iron uptake by DPs and provides an opportunity for recycling a discarded processing byproduct. © 2018 Society of Chemical Industry

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“…The organ coefficient was calculated by the following formula: 21,22 Organ coefficient ¼ organ weight=rat body weight Â 100: A gross pathology examination was performed by visual inspection during the necropsy.…”

Section: Preparation Of Iron-enriched Yeast No Ym1504 and Cell Iron mentioning

confidence: 99%

Effects of Fe-YM1504 on iron deficiency anemia in rats

et al. 2016

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Iron deficiency anemia (IDA) is one of the most serious forms of malnutrition. It is possible that some strains present in the natural environment possess a higher tolerance to inorganic iron and a higher ability to convert and accumulate iron compared with Saccharomyces cerevisiae wild-type strain. In the present study, the strain no. YM1504, able to grow in an iron-rich environment, was used as a potential organic iron supplement, and its efficacy in alleviating IDA in rats was investigated. Sixty female weanling Sprague-Dawley rats were randomly divided into a normal control group fed with a standard diet and a model group fed with an iron-deficient diet to create the IDA model. After the model was established, IDA rats were further randomly divided into five subgroups: the IDA group, the ferrous sulfate (FeSO4) group and Fe-YM1504 low-, medium- or high-dose groups receiving different concentrations of Fe-YM1504 supplements. Our results showed that Fe-YM1504 has an effective restorative function by returning the hemoglobin (Hb), hematocrit (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), serum iron (SI), total iron binding capacity (TIBC), serum ferritin (SF), etc. in IDA animals to the normal level. Moreover, malondialdehyde and the enzyme activities of superoxide dismutase and glutathione peroxidase in both plasma and liver homogenate were improved. Finally, compared with the FeSO4 group, the Fe-YM1504 middle-dose was more effective in alleviating IDA and fewer side effects were observed. The present study indicated that iron-enriched strain no. YM1504 might play a significant role in ameliorating IDA rats and might be exploited as a new iron supplement.

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Effects of heme iron enriched peptide on iron deficiency anemia in rats

Cited by 40 publications

References 55 publications

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Effects of a Tripeptide Iron on Iron-Deficiency Anemia in Rats

Effect of duck egg white peptide‐ferrous chelate on iron bioavailability in vivo and structure characterization

Effects of Fe-YM1504 on iron deficiency anemia in rats

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