Effects of herpes virus carrier status on peripheral T lymphocyte subsets

Jw, Gratama; Naipal, A; Oosterveer, M. A. P.; Stijnen, Theo; Kluin‐Nelemans, Hanneke C.; Ginsel, L.A.; Ottolander, G. J. den; Hekker, A. C.; D'Amaro, J; Giessen, M. van der

doi:10.1182/blood.v70.2.516.516

Cited by 44 publications

(16 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table 2 shows the results of the comparisons between (i) PNS versus SCLC; (ii) PNS versus HC; and (iii) SCLC versus HC, after adjusting for the influences of age, gender and CMV serostatus. In agreement with earlier observations [33][34][35][36], increasing age was associated with significantly lower numbers of B cells,…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Imbalances in circulating lymphocyte subsets in Hu antibody associated paraneoplastic neurological syndromes

Beukelaar

Smitt

Hop

et al. 2007

Euro J of Neurology

View full text Add to dashboard Cite

In paraneoplastic neurological syndromes (PNS) associated with small cell lung cancer (SCLC) and Hu antibodies, neuron-specific Hu antigens expressed by the tumour hypothetically trigger an immune response that cross-reacts with Hu antigens in the nervous system, resulting in tumour suppression and neuronal damage. To gain more insight into the hypothesized cell-mediated immune pathogenesis of these syndromes, we analysed the circulating lymphocyte subsets in untreated patients with SCLC, PNS and Hu antibodies (n = 18), SCLC without PNS (n = 19) and controls (n = 29) using flow cytometry. SCLC patients with PNS had a variety of imbalances within their circulating lymphocyte subsets as compared with SCLC patients without PNS and healthy controls: (i) a lymphopenia of the major subsets (i.e. B, CD4+ and CD8+ T lymphocytes); (ii) increased proportions of activated CD4+ and CD8+ T cells; (iii) reduced numbers of terminally differentiated effector CD8+ T cells and cells with a cytotoxic T-cell phenotype (CD56+ and CD57+). Although indirect, our data provide further support for the involvement of T cells in the pathogenesis of Hu antibody associated PNS.

show abstract

Section: Discussionsupporting

confidence: 93%

“…Age, gender and CMV serostatus have significant impacts on the numbers and phenotypes of the lymphocyte subsets under study [33][34][35][36]. Therefore, paired comparisons between the various groups were performed using ANCOVA with covariates CMV serostatus, age and gender [SPSS version 11.5 (SPSS Inc., Chicago, IL, USA)].…”

Section: Discussionmentioning

confidence: 99%

Imbalances in circulating lymphocyte subsets in Hu antibody associated paraneoplastic neurological syndromes

Beukelaar

Smitt

Hop

et al. 2007

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

“…Individuals with chronic CMV infection have a more differentiated peripheral blood CD8 T-cell population than uninfected individuals. [2][3][4][5][6]13 We found an increase in the proportion of differentiated CD8 T cells was caused by an increase in the absolute number of differentiated cells, defined by loss of CCR7, CD28 and CD27, and expression of CD57. Also, the number of undifferentiated CD8 T cells was unaffected by CMV infection.…”

Section: Discussionmentioning

confidence: 71%

“…1 Chronic infection of senior citizens is associated with a large expansion of the differentiated CD28 ) CD57 + subpopulation of CD8 T-cells and a smaller expansion of the equivalent subpopulation of CD4 T-cells. [2][3][4][5][6][7] The expansion of differentiated, and possibly immunosenescent, CD8 T-cells contributes to an 'immune risk phenotype', 8 which may also include an inversion of the ratio of CD4 and CD8 T-cells in extreme cases. 3,5 Both the immune risk phenotype 9,10 and CMV infection 11 are associated with poor responses to the influenza vaccine and to Epstein-Barr virus (EBV), 12 another persistent herpesvirus.…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus infection induces T‐cell differentiation without impairing antigen‐specific responses in Gambian infants

et al. 2008

View full text Add to dashboard Cite

Summary Cytomegalovirus (CMV) infection induces profound differentiation of T cells, and is associated with impaired responses to other immune challenges. We therefore considered whether CMV infection and the consequent T‐cell differentiation in Gambian infants was associated with impaired specific responses to measles vaccination or polyclonal responses to the superantigen staphylococcal enterotoxin B (SEB). While the concentration of undifferentiated (CD27+ CD28+ CCR7+) T‐cells in peripheral blood was unaffected by CMV, there was a large increase in differentiated (CD28− CD57+) CD8 T‐cells and a smaller increase in differentiated CD4 cells. One week post‐vaccination, the CD4 cell interferon‐γ (IFN‐γ) response to measles was lower among CMV‐infected infants, but there were no other differences between the cytokine responses, or between the cytokine or proliferative responses 4 months post‐vaccination. However, the CD8 T cells of CMV‐infected infants proliferated more in response to SEB and the antibody response to measles correlated with the IFN‐γ response to CMV, indicating that CMV infection actually enhances some immune responses in infancy.

show abstract

“…Earlier studies on the composition of the different T cell subsets indicated that CMV infection markedly altered their ratios 6 and reported expansions of CD8 + CD57 + subsets in CMV-seropositive individuals. Increases of cells with this same phenotype were independently found to be associated with increasing age in other studies.…”

Section: Hypothesismentioning

confidence: 99%

Human Immunosenescence

Pawelec

Koch

Franceschi³

et al. 2006

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

The rate of acceleration of the frequency of death due to cardiovascular disease or cancer increases with age from middle age up to around 75-80 years, plateauing thereafter. Mortality due to infectious disease, however, does not plateau, but continues to accelerate indefinitely. The elderly are particularly susceptible to novel infectious agents such as SARS, as well as to previously encountered pathogens. Why is this? The elderly commonly possess oligoclonal expansions of T cells, especially of CD8 cells, which, surprisingly, are associated with cytomegalovirus (CMV) seropositivity. This in turn is associated with many of the same phenotypic and functional alterations to T cell immunity that have been suggested as biomarkers of immune system aging. We suggest that, in fact, CMV, not age per se, is the prime driving force behind many or most of the oligoclonal expansions and altered phenotypes and functions of CD8 cells in the elderly. Thus, the manner in which CMV and the host immune system interact (over which period? on which genetic background? with which co-infections?) is critical in determining the "age" of adaptive immunity and hence human longevity. In this respect, immunosenescence is infectious.

show abstract

Effects of herpes virus carrier status on peripheral T lymphocyte subsets

Cited by 44 publications

References 36 publications

Imbalances in circulating lymphocyte subsets in Hu antibody associated paraneoplastic neurological syndromes

Imbalances in circulating lymphocyte subsets in Hu antibody associated paraneoplastic neurological syndromes

Cytomegalovirus infection induces T‐cell differentiation without impairing antigen‐specific responses in Gambian infants

Human Immunosenescence

Contact Info

Product

Resources

About